Results 41 to 50 of about 168,162 (295)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Gas-Phase Construction of Compact Capping Layers for High-Performance Halide Perovskite X-Ray Detectors

Nano-Micro Letters
Highlights A gas-phase method has been developed, which can directly grow two-dimensional perovskite on three-dimensional perovskite with nanoscale precision. The steric hindrance of the organic layer within 2D perovskites influences the ion migration in
Bin Zhang, Chuanyun Hao, Shoufeng Zhang, Bin Xue, Xiangfan Xie, Shengqiao Zeng, Bin Yang, Fang Xu, Hui Li, Xin’an Zhang, Zhang Qu, Kai-Hang Ye, Guangda Niu, Wallace C. H. Choy, Kezhou Fan, Kam Sing Wong, Lei Yan, Xingzhu Wang, Shuang Xiao, Cangtao Zhou   +19 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Unlocking Plant‐Derived Potential: Regulating Microcrystalline Structure Design of High‐performance Hard Carbon Anodes via Cellulose Molecules

Advanced Science
Biomass‐derived hard carbon (HC) stands as the leading candidate for the anode in commercial sodium‐ion batteries (SIBs). However, the effect of precursor components on the formation of HC at the molecular level breezing, and the evolution mechanism of ...
Xiping Zhang, Wenhao Yang, Dan You, Ziyi Zhu, Xue Li   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Investigation into the Influence of Alkyl Thioureas with Varying Steric Hindrance on the Tensile Strength of Electrolytic Copper Foil

Advanced Materials Interfaces
Thiourea derivatives are typical additives that exert different steric hindrance effects on the tensile strength of electrolytic copper foil (ECF). However, the underlying mechanisms remain unclear.
Mingwei Chen, Xing Hu, Jian Huang, Dongmei Wu, Chen Shi, Ning Song, Yuhui Tan, Chao Liu, Yunzhi Tang   +8 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Catalytic enantioselective construction of axial chirality in 1,3-disubstituted allenes

Nature Communications, 2019
Highly enantioselective synthesis of allenes has been relying, so far, on the steric hindrance of substrates. Here the authors achieve excellent stereocontrol in the synthesis of chiral allenes with a palladium-DTBM-SEGPHOS catalytic system in a non ...
Shihua Song, Jing Zhou, Chunling Fu, Shengming Ma   +3 more
doaj   +1 more source

steric hindrance

, 2014
Citation: 'steric hindrance' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.S06000 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source