Results 61 to 70 of about 168,162 (295)
Steric Hindrance and Geometrical Isomerism [PDF]
Nature, 1934 IT is not often that evidence in the form of steric hindrance is available for confirming the configurations of geometrical isomers among ethylenic compounds. The following observations are thus of interest. cis--Dibromocinnamic acid1 (m.p. 100°) esterifies to the extent of only 6 per cent in one hour, and 33 per cent in 16 hours, by the Fischer-Speier
openaire +1 more source
Blocking cyclobutane pyrimidine dimer formation by steric hindrance [PDF]
, 2016 The efficiency of thymine (Thy) and uracil (Ura) to form cyclobutane pyrimidine dimers (CPDs) in solution, upon UV irradiation differs by one order of magnitude.
Lhiaubet, Virginie Lyria +4 more
core +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Inhibition of Amyloid Nucleation by Steric Hindrance
Despite recent experiments and simulations suggesting that small-molecule inhibitors and some post-translational modifications (e.g., glycosylation and ubiquitination) can suppress the pathogenic aggregation of proteins due to steric hindrance, the ...
Kai Wu (221862) +4 more
core +1 more source
, 2007 The steric hindrance of the 7 alpha-OR group in bile acid derivatives is very different from the 12 alpha-OR group. The effect of this difference in steric hindrance on the synthesis of cyclocholates has been evaluated with support from AM1 and MM2 ...
Rashdan, Suad A. +2 more
core +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Steric Hindrance Governs the Photoinduced Structural Planarization of Cycloparaphenylene Materials
Cycloparaphenylenes ([n]CPPs) and their derivatives are known for the unique size-dependent photophysical properties, which are largely attributed to the structural planarization-associated exciton localization, attracting substantial research attention.
Shunwei Chen (1754173) +5 more
core +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
, 2000 Rejection characteristics of arsenic compounds such as arsenite, dimethyl arsinic acid, and arsenate were examined regarding the effect of pH change in nanofiltration.
H. Kitawaki +5 more
core +1 more source