Results 31 to 40 of about 168,162 (295)

Steric-Hindrance-Controlled Laser Switch Based on Pure Metal–Organic Framework Microcrystals

open access: yes, 2019
Herein, we demonstrated a steric-hindrance-controlled laser switch in pure metal–organic framework (MOF) microcrystals. The well-faceted MOF microwires with aggregation-induced emission (AIE) lumnogens as linkers function as typical Fabry–Pérot ...
Yong Sheng Zhao (1411612)   +13 more
core   +1 more source

Structure-guided protein design of fluoroacetate dehalogenase for kinetic resolution of rac-2-bromobutyric acid

open access: yesGreen Synthesis and Catalysis, 2020
R-2-Bromobutyric acid is a very important intermediate for the synthesis of agrochemicals and pharmaceuticals. Bioresolution of rac-2-bromobutyric acid (rac-2-BBA) provides a promising process for R-2-bromobutyric acid (R-2-BBA) production.
Shu Wang   +6 more
doaj   +1 more source

Antibodies targeting enzyme inhibition as potential tools for research and drug development

open access: yesBiomolecular Concepts, 2021
Antibodies have transformed biomedical research and are now being used for different experimental applications. Generally, the interaction of enzymes with their specific antibodies can lead to a reduction in their enzymatic activity.
Pérez de la Lastra José Manuel   +5 more
doaj   +1 more source

Syntheses and Steric Hindrances in 13β-Isopropylgonanes

open access: yesChemical and Pharmaceutical Bulletin, 1965
dl-18, 18-Dimethylestradiol 3-methyl ether (XII), dl-18, 18-dimethyl-19-nortestosterone (II) and their derivatives were synthesized starting from 1-vinyl-6-methoxy-1-tetralol (III) and 2-isopropyl-1, 3-crclopentanedione (IV). The steric effect of the 13-isopropyl group over 17-position was observed in every kind of reactions in this series. Both II and
Hiraga, Kentaro   +2 more
openaire   +2 more sources

Additional file 2 of Structure-guided steric hindrance engineering of Bacillus badius phenylalanine dehydrogenase for efficient l-homophenylalanine synthesis

open access: yes, 2021
Additional file 2: Figure S1. Time course of asymmetric reductive amination of 2-OPBA catalyzed by BbPheDH and GkPheDH. Figure S2. Amino acid sequence alignment of the PheDHs from different sources. Figure S3. Relative activity of the single-site mutants
Xiaoqing Mu (11600809)   +4 more
core   +1 more source

Full three-dimensional morphology evolution of amorphous thin films for atomic layer deposition

open access: yesAIP Advances, 2018
We introduce a Monte Carlo model based on random deposition and diffusion limited aggregation in order to study the morphological evolution of deposition of nanofilm, which is difficult to carry out by the experimental methods.
Lingpeng Jin   +3 more
doaj   +1 more source

Steric Hindrance Induces crosslike Self-Assembly of Gold Nanodumbbells

open access: yes, 2016
In the formation of colloidal molecules, directional interactions are crucial for controlling the spatial distribution of the building blocks. Anisotropic nanoparticles facilitate directional clustering via steric constraints imposed by each specific ...
Luis M. Liz-Marzán (1267962)   +5 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections

open access: yesNature Communications, 2021
Although enterovirus D68 poses a major global threat to children, neither vaccines nor therapeutics are currently available. Using Cryo-EM, Zhang et al.
Chao Zhang   +10 more
doaj   +1 more source

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