Results 21 to 30 of about 75,973 (258)
Green Synthesis and Catalysis, 2020 R-2-Bromobutyric acid is a very important intermediate for the synthesis of agrochemicals and pharmaceuticals. Bioresolution of rac-2-bromobutyric acid (rac-2-BBA) provides a promising process for R-2-bromobutyric acid (R-2-BBA) production.
Shu Wang +6 more
doaj +1 more source
Syntheses and Steric Hindrances in 13β-Isopropylgonanes
Chemical and Pharmaceutical Bulletin, 1965 dl-18, 18-Dimethylestradiol 3-methyl ether (XII), dl-18, 18-dimethyl-19-nortestosterone (II) and their derivatives were synthesized starting from 1-vinyl-6-methoxy-1-tetralol (III) and 2-isopropyl-1, 3-crclopentanedione (IV). The steric effect of the 13-isopropyl group over 17-position was observed in every kind of reactions in this series. Both II and
Hiraga, Kentaro +2 more
openaire +2 more sources
Antibodies targeting enzyme inhibition as potential tools for research and drug development
Biomolecular Concepts, 2021 Antibodies have transformed biomedical research and are now being used for different experimental applications. Generally, the interaction of enzymes with their specific antibodies can lead to a reduction in their enzymatic activity.
Pérez de la Lastra José Manuel +5 more
doaj +1 more source
Nature Communications, 2021 Although enterovirus D68 poses a major global threat to children, neither vaccines nor therapeutics are currently available. Using Cryo-EM, Zhang et al.
Chao Zhang +10 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Nano-Micro LettersHighlights A gas-phase method has been developed, which can directly grow two-dimensional perovskite on three-dimensional perovskite with nanoscale precision. The steric hindrance of the organic layer within 2D perovskites influences the ion migration in
Bin Zhang +19 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Advanced ScienceBiomass‐derived hard carbon (HC) stands as the leading candidate for the anode in commercial sodium‐ion batteries (SIBs). However, the effect of precursor components on the formation of HC at the molecular level breezing, and the evolution mechanism of ...
Xiping Zhang +4 more
doaj +1 more source