Results 211 to 220 of about 262,141 (236)
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Nucleic acid driven sterile inflammation
Clinical Immunology, 2013The etiology of sterile inflammatory conditions is complex and affected by a variety of genetic, environmental and stochastic factors. But despite this overt complexity, progress has been made in elucidating mechanisms underlying disease pathogenesis. An intriguing new finding that has emerged over the past years was the realization that innate immune ...
Andrea, Ablasser +3 more
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DAMPs and sterile inflammation in drug hepatotoxicity
Hepatology International, 2018Drug hepatotoxicity is the leading cause of acute liver failure (ALF) in the developed countries. The early diagnosis and treatment are still problematic, and one important reason is the lack of reliable mechanistic biomarkers and therapeutic targets; therefore, searching for new biomarkers and therapeutic targets is urgent. Drug hepatotoxicity induces
Runkuan Yang, Tor Inge Tonnesseen
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Malondialdehyde epitopes as mediators of sterile inflammation
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017Enhanced lipid peroxidation occurs during oxidative stress and results in the generation of lipid peroxidation end products such as malondialdehyde (MDA), which can attach to autologous biomolecules, thereby generating neo-self epitopes capable of inducing potentially undesired biological responses. Therefore, the immune system has developed mechanisms
Clara J, Busch, Christoph J, Binder
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Sterile Solutions and Peritoneal Inflammation
2006There is now abundant evidence in both animal and human studies that sterile dialysis solutions result in the alteration of the peritoneal barrier. Mesothelial cells undergo an epithelialto- mesenchymal transition after less than 1 year of dialysis. After more than 6 years of peritoneal dialysis, there is extensive fibrosis and neoangiogenesis in the ...
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ApoC3: an ‘alarmin’ triggering sterile inflammation
Nature Immunology, 2019NLRP3-driven sterile inflammation facilitates the pathogenesis of various human inflammatory diseases. New work identifies apolipoprotein C3 as an endogenous NLRP3 agonist that promotes sterile inflammation and organ damage.
Tao Gong, Rongbin Zhou
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Platelets and HMGB1 in Sterile and Non-sterile Inflammation
2017Platelets play a critical role in hemostasis, thrombosis, wound healing, and inflammation. We have recently shown that the damage-associated molecular pattern molecule (DAMP) high-mobility group box 1 (HMGB1) derived from platelets plays a critical role in mediating thrombosis and inflammation.
Sebastian Vogel, Meinrad Gawaz
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Mitochondria and sterile inflammation in the heart
Current Opinion in Physiology, 2018Chronic inflammation without microbial infection, termed sterile inflammation, plays crucial roles in the development of heart failure. Mechanistically, the process of sterile inflammation starts with the sensing of damage-associated molecular patterns (DAMPs) via multiple pattern recognition receptors.
Nakayama, Hiroyuki, Otsu, Kinya
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Chaperones in Sterile Inflammation and Injury
2019Heat shock proteins (Hsp) are highly conserved proteins and their expression increases in response to stress stimuli for the maintenance of cellular homeostasis. Cellular stress conditions like hypoxia, change in pH, and metabolic changes are typically associated with upregulation of HSP.
Asmita Choudhury, Pranoti Mandrekar
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Mechanisms of sterile inflammation in the testis
2018Causes of human male infertility are only partially known. In the numerous idiopathic cases, the underlying causes remain unknown. Sterile inflammation of the testis, which frequently proceeds asymptomatically and therefore stays undetected, may be involved. This scenario has often been associated with increased numbers of immune cells infiltrating the
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