Results 51 to 60 of about 865,495 (343)

The Use of Chinese Yang/Qi-Invigorating Tonic Botanical Drugs/Herbal Formulations in Ameliorating Chronic Kidney Disease by Enhancing Mitochondrial Function

Frontiers in Pharmacology, 2021
Background: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality. Mitochondrial dysfunction has been implicated as a key factor in the development of CKD.
Jiayi Tian, Jiayi Tian, Yuqi Huang, Yuqi Huang, Tong Wu, Tong Wu, Hsien-Da Huang, Hsien-Da Huang, Kam Ming Ko, Bao Ting Zhu, Bao Ting Zhu, Jihang Chen, Jihang Chen   +12 more
doaj   +1 more source

Fate of conjugated natural and synthetic steroid estrogens in crude sewage and activated sludge batch studies [PDF]

, 2009
This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Environmental Science & Technology, copyright © American Chemical Society after peer review.
Alcock R. E., Baronti C., Bitton G., Brown J. B., Bursch W., Desbrow C., Dray J., D’Ascenzo G., Fotsis T., Gentilli A., Gomes R. L., Gomes R. L., Gomes R. L., Gomes R. L., Guengerich F. P., Isobe T., Johnson A. C., Johnson A. C., Jones O. A. H., Koh Y. K. K., Komori K., Panter G. H., Ranney R. E., Reddy S., Routledge E. J., Schlüsener M. P., Solé M., Tang P. W., Ternes T. A., Ternes T. A., Vandenheuvel F. A., Yamamoto A., Zhang H.   +32 more
core   +1 more source

Steroids and Autoimmunity [PDF]

, 2017
From the middle of the 19th century, it is known that endocrine and immune systems interact bi-directionally in different processes that ensure organism homeostasis. Endocrine and nervous systems have a pivotal role in the balancing of pro- and anti-inflammatory functions of immune system, and constitute a complex circadian neuroendocrine network ...
TROMBETTA, AMELIA CHIARA, MERONI, MARIANNA, CUTOLO, MAURIZIO   +2 more
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Steroid estrogen determination in sediment and sewage sludge: A critique of chromatographic / mass spectrometry methods incorporating a case study in method development [PDF]

, 2004
Current analytical methods for determining steroids in sewage sludge and sediment are reviewed and experimental data comparing LC/MS ESI and GC/MS quantification of extracts from these matrices is presented.
Avcioglu, E, Gomes, RL, Lester, JN, Scrimshaw, MD   +3 more
core   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Spinal Cord Abnormalities in Early Pediatric Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Spinal cord lesions and atrophy in the cervical region are common in adult multiple sclerosis (MS) and correlate with disability. Whether similar abnormalities occur in pediatric MS patients is largely unknown. Clinical and MRI evaluations were performed in 38 pediatric MS patients and 13 healthy controls (HC).
Monica Margoni, Paola Valsasina, Paolo Preziosa, Martina Rubin, Mor Gueye, Lucia Moiola, Maria Assunta Rocca, Massimo Filippi   +7 more
wiley   +1 more source

ADHD symptoms and use of anabolic androgenic steroids among male weightlifters

Scientific Reports, 2022
Use of anabolic androgenic steroids (AAS) is associated with adverse health effects. The factors that predispose to AAS use among athletes are poorly understood, but attention deficit/hyperactivity disorder (ADHD), which is known to occur among athletes ...
Emilie Kildal, Bjørnar Hassel, Astrid Bjørnebekk   +2 more
doaj   +1 more source

Environmental concentrations of anti-androgenic pharmaceuticals do not impact sexual disruption in fish alone or in combination with steroid oestrogens [PDF]

, 2015
This article has been made available through the Brunel Open Access Publishing Fund.Sexual disruption in wild fish has been linked to the contamination of river systems with steroid oestrogens, including the pharmaceutical 17α-ethinylestradiol ...
Brian, J, Green, C, Jobling, S, Kanda, R, Scholze, M, Williams, R   +5 more
core   +2 more sources

Plasma microRNA Signature as Predictive Marker of Clinical Response to Therapy During Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite the availability of effective therapies for Multiple Sclerosis (MS), the unpredictable nature of disease progression and the variability in individual treatment outcomes call for reliable biomarkers. This pilot study aims to investigate the potential of plasma circulating microRNAs (miRNAs) as predictive biomarkers for ...
Fortunata Carbone, Alessandra Colamatteo, Teresa Micillo, Gianmarco Abbadessa, Silvia Garavelli, Clorinda Fusco, Claudia Russo, Francesco Perna, Federica Garziano, Claudia La Rocca, Maria Mottola, Giorgia Teresa Maniscalco, Simona Bonavita, Antonio Luca Spiezia, Alessia Castiello, Roberta Lanzillo, Vincenzo Brescia Morra, Claudio Procaccini, Paola de Candia, Giuseppe Matarese   +19 more
wiley   +1 more source