Results 1 to 10 of about 64,856 (60)

Cholesterol impairment contributes to neuroserpin aggregation [PDF]

Scientific Reports 7, Article number: 43669 (2017), 2017
Intraneural accumulation of misfolded proteins is a common feature of several neurodegenerative pathologies including Alzheimer's and Parkinson's diseases, and Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB). FENIB is a rare disease due to a point mutation in neuroserpin which accelerates protein aggregation in the endoplasmic ...
arxiv   +1 more source

Towards a Molecular Level Understanding of the Sulfanilamide-Soil Organic Matter-Interaction [PDF]

Science of the Total Environment 559, 347 (2016), 2016
In-depth understanding of the sorption mechanisms of organic pollutants, like the antibiotic sulfanilamide (SAA), in soil requires a combined experimental and theoretical approach. Therefore, sorption experiments of SAA on well-characterized samples of soil size-fractions were combined with the modeling of SAA-soil-interaction via quantum chemical ...
arxiv   +1 more source

A comparative study of the lipid panel levels at different duration time and temperature storage [PDF]

arXiv, 2023
Background: the stability of serum specimen during time storage is importance in clinical and medical science researches in addition of diagnosis. Lipids are organic molecules that classified into 8 classes: fatty acids, phospholipids, glycerolipids, saccharolipids, polyketides, prenol lipids, sterol, and sphingolipids.
arxiv  

Sterols sense swelling in lipid bilayers [PDF]

, 1998
In the mimetic membrane system of phosphatidylcholine bilayers, thickening (pre-critical behavior, anomalous swelling) of the bilayers is observed, in the vicinity of the main transition, which is non-linear with temperature. The sterols cholesterol and androsten are used as sensors in a time-resolved simultaneous small- and wide angle x-ray ...
arxiv   +1 more source

Coarse-Grained Model for Phospholipid/Cholesterol Bilayer [PDF]

, 2004
We construct a coarse-grained (CG) model for dipalmitoylphosphatidylcholine (DPPC)/cholesterol bilayers and apply it to large-scale simulation studies of lipid membranes. Our CG model is a two-dimensional representation of the membrane, where the individual lipid and sterol molecules are described by point-like particles.
arxiv   +1 more source

Effect of Cholesterol vs. Ergosterol on DPPC Bilayer Properties: Insights from Atomistic Simulations [PDF]

arXiv, 2020
Sterols have been ascribed a major role in the organization of biological membranes, in particular for the formation of liquid ordered domains in complex lipid mixtures. Here, we employed molecular dynamics simulations to compare the effects of cholesterol and ergosterol as the major sterol of mammalian and fungal cells, respectively, on binary ...
arxiv  

Computational Modelling of Atherosclerosis [PDF]

, 2015
Atherosclerosis is one of the principle pathologies of cardiovascular disease with blood cholesterol a significant risk factor. The World Health Organisation estimates that approximately 2.5 million deaths occur annually due to the risk from elevated cholesterol with 39% of adults worldwide at future risk.
arxiv   +1 more source

Comparative study of the biological activities of the aqueous extracts of two spontaneous plants harvested in the Algerian Sahara [PDF]

arXiv, 2020
The present study investigates the insecticidal and herbicidal effects of leaf extracts from two plants were harvested in the Northern Algerian Sahara. These are Cleome arabica (Capparaceae) and Pergularia tomentosa (Asclepiadaceae). The efficacy of the extracts from the plants was evaluated by the reflux extraction method.
arxiv  

Description, distribution and ecology of living Reophax pyriformis n. sp. (Campos Basin, South Atlantic Ocean) [PDF]

arXiv, 2019
The distribution of living (rose Bengal stained) Reophax pyriformis Yamashita, Sousa and Kaminski, n. sp., an agglutinated benthic foraminiferal species, was analyzed in the area of the Campos Basin (southeastern Brazilian continental margin). The study is based on 34 oceanographic stations (54 samples), located between 400 m and 3,000 m water depth ...
arxiv  

A unified model for the origins of spongiform degeneration and other neuropathological features in prion diseases [PDF]

arXiv
Decades after their initial observation in prion-infected brain tissues, the identities of virus-like dense particles, varicose tubules, and oval bodies containing parallel bands and fibrils have remained elusive. Our recent work revealed that a phenotype of dilation of the endoplasmic reticulum (ER), most notable for the perinuclear space (PNS ...
arxiv