Results 11 to 20 of about 126,548 (250)

Molecular Dynamics-Guided Sterol Engineering of mRNA-Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen-Selective Immunity. [PDF]

Adv Sci (Weinh)
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Jeon S, Bae SH, Ji J, Lee J, Choi H, Kang MH, Park SI, Kim H, Lee N, Lee H, Kim S, Kim J, Yoon S, Lee S, Cho S, Ha D, Oh A, Jo S, Choi H, Lee Y, Lee S, Park HJ, Nam G, Shin J, Kang Y, Im W, Lee K, Nam JH.   +27 more
europepmc   +2 more sources

Sterol assimilation by Saccharomyces cerevisiae [PDF]

Sterols of the yeast Saccharomyces cerevisiae are found in membranes with a free C-3,β hydroxyl group or stored in lipid droplets as esters of long-chain fatty acids.
Lewis, Thomas A.
core   +6 more sources

Sterol content in sunflower seeds (Helianthus annuus L.) as affected by genotypes and environmental conditions [PDF]

, 2010
Phytosterols play essential roles in many plant cell mechanisms. They are of industrial interest since, as part of the diet, they can reduce Low Density Lipoprotein cholesterol.
Roche, Jane, J., Merah, Othmane,, Merah, Othmane, O., Vear, Felicity,, Mouloungui, Zephirin,, Alignan, Marion,, Alignan, Marion, M., Cerny, Muriel, M., Bouniols, Andrée,, Vear, Felicity, Mouloungui, Zéphirin, Cerny, Muriel,, Merah, Othmane, Roche, Jane,, Mouloungui, Zephirin, Z., Cerny, Muriel, Bouniols, Andrée, A., Bouniols, Andrée, Vear, Felicity, F., Alignan, Marion, Roche, Jane   +20 more
core   +1 more source

Neutral glycolipids of the filamentous fungus Neurospora crassa:altered expression in plant defensin-resistant mutants

Journal of Lipid Research, 2005
To defend themselves against fungal pathogens, plants produce numerous antifungal proteins and peptides, including defensins, some of which have been proposed to interact with fungal cell surface glycosphingolipid components.
Chaeho Park, Beau Bennion, Isabelle E.J.A. François, Kathelijne K.A. Ferket, Bruno P.A. Cammue, Karin Thevissen, Steven B. Levery   +6 more
doaj   +1 more source

Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole

eLife, 2017
Niemann-Pick type C is a storage disease caused by dysfunction of NPC proteins, which transport cholesterol from the lumen of lysosomes to the limiting membrane of that compartment.
Takuma Tsuji, Megumi Fujimoto, Tsuyako Tatematsu, Jinglei Cheng, Minami Orii, Sho Takatori, Toyoshi Fujimoto   +6 more
doaj   +1 more source

Kinetic modelling of sterol transport between plasma membrane and endo-lysosomes based on quantitative fluorescence and X-ray imaging data

Frontiers in Cell and Developmental Biology, 2023
Niemann Pick type C1 and C2 (NPC1 and NPC2) are two sterol-binding proteins which, together, orchestrate cholesterol transport through late endosomes and lysosomes (LE/LYSs).
Daniel Wüstner, Alice Dupont Juhl, Jacob Marcus Egebjerg, Stephan Werner, James McNally, Gerd Schneider   +5 more
doaj   +1 more source

The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway [PDF]

, 2009
© 2009 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Jacquier, N, Höfken, T, Lin, Meng, Jacquier, Nicolas, Schneiter, R, Unden, H, Just, Ursula, Just, U, Unden, Heike, Höfken, Thomas, Schneiter, Roger   +10 more
core   +1 more source

Sterol concentration and distribution in sunflower seeds (Helianthus annuus L.) during seed development [PDF]

, 2010
Sunflower seeds are currently used for edible oil production. Among oil minor compounds, phytosterols are of special interest due to their cholesterol reducing properties.
Merah, O, Mouloungui, Zephirin,, Alignan, Marion,, Alignan, Marion, M., Cerny, Muriel, M., Mouloungui, Zéphirin, Cerny, Muriel,, Merah, Othmane, Mouloungui, Zephirin, Z., Cerny, Muriel, Bouniols, Andrée, Alignan, Marion, Roche, Jane   +12 more
core   +1 more source

Solid phase extraction of β-sitosterol and α-tocopherol from sunflower oil deodorizer distillate using desilicated zeolite

Grasas y Aceites, 2020
In this study, the efficiency of using zeolite-based adsorbents in a solid phase extraction (SPE) procedure of α-tocopherol and β-sitosterol isolation from Sunflower Oil Deodorizer Distillate (SuDOD) with­out pre-treatment was investigated.
O. Karaoglu, G. Alpdogan, I. S. Ozdemir, E. Ertas   +3 more
doaj   +1 more source

Metabolism and Biological Activities of 4-Methyl-Sterols

Molecules, 2019
4,4-Dimethylsterols and 4-methylsterols are sterol biosynthetic intermediates (C4-SBIs) acting as precursors of cholesterol, ergosterol, and phytosterols.
Sylvain Darnet, Hubert Schaller
doaj   +1 more source