Results 201 to 210 of about 126,548 (250)

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

open access: yesThe FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

SOAT1 Nonsense Variant in a Cat With Sebaceous Gland Dysplasia. [PDF]

open access: yesAnim Genet
Kammermann L   +5 more
europepmc   +1 more source

UbiB proteins mediate an ATP‐dependent decarboxylation step in bacterial ubiquinone biosynthesis

open access: yesThe FEBS Journal, EarlyView.
UbiB proteins are atypical protein kinase‐like enzymes essential for ubiquinone biosynthesis. Here, we demonstrate that bacterial UbiB proteins catalyze the O2‐dependent decarboxylation of ubiquinone precursors, a process linked to their ATPase activity.
Katayoun Kazemzadeh   +12 more
wiley   +1 more source

High‐Fat Diet Reprograms the Periapical Immune Landscape in a Mouse Model of Apical Periodontitis: A Spatial Transcriptomics Study

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Introduction Apical periodontitis (AP) is an inflammatory disease of the periapical tissues driven by host responses to endodontic infection, and systemic metabolic disturbances, such as high‐fat diet (HFD)–induced dysmetabolism, may exacerbate tissue destruction. This study aimed to determine how chronic HFD exposure alters periapical myeloid
Maryam Ghaffari   +3 more
wiley   +1 more source

Associations between diet quality and adult acne: A cross sectional study in the UK Biobank

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Mediterranean‐style diet adherence was associated with lower odds of adult acne, particularly in women. In men, a low‐carbohydrate, high‐meat dietary pattern showed higher odds. Cooked vegetables and yoghurt were inversely associated, whereas pork, skimmed milk and milk‐based desserts showed positive associations.
Bochen Li   +7 more
wiley   +1 more source

The History of the Discovery of Vitamin K. [PDF]

open access: yesBasic Clin Pharmacol Toxicol
Tuxen HN, Zwisler L, Linneberg A.
europepmc   +1 more source

Modulation of sebocyte function in acne: A pathway‐inclusive review

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis   +3 more
wiley   +1 more source

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