Results 91 to 100 of about 16,062 (239)

Biochemical and Physiological Effects of Galanin in Health and Disease

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles, Yubo Wang, Kathryn Rhodes, Sharon DeMorrow   +3 more
wiley   +1 more source

Role of reactive oxygen species in regulating 27-hydroxycholesterol-induced apoptosis of hematopoietic progenitor cells and myeloid cell lines

Cell Death and Disease, 2022
Oxysterols are oxygenated derivatives of cholesterol that contain an additional hydroxy, epoxide, or ketone group in the sterol nucleus and/or a hydroxyl group in the side chain of the cholesterol molecule.
Soo-Yeon Woo, Hansong Lee, Su Min Park, Hee-Seon Choi, Jayoung Kim, Munju Kwon, Jihyung Sohn, Ji Ho Nam, Hyung-Sik Kim, Parkyong Song, Ninib Baryawno, Yun-Hak Kim, Koanhoi Kim, Dongjun Lee   +13 more
doaj   +1 more source

Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51) [PDF]

, 2015
Herein, we have investigated the amebicidal activities of the pharmaceutical triazole CYP51 inhibitors fluconazole, itraconazole, and voriconazole against Acanthamoeba castellanii and Acanthamoeba polyphaga and assess their potential as therapeutic ...
Andrew G. S. Warrilow, David C. Lamb, Diane E. Kelly, Josie E. Parker, Nicola J. Rolley, Stephen N. Smith, Steven L. Kelly, W. David Nes   +7 more
core   +1 more source

Bile Acids as Key Mediators of the Gut Microbiota–Immune Axis: Potential Biomarker and Therapeutic Perspectives

BioFactors, Volume 52, Issue 1, January/February 2026.
Primary bile acids synthesized in the liver are transformed by gut microbes into secondary bile acids that engage receptors such as FXR and TGR5, thereby modulating immune function and metabolic homeostasis. Dysregulation of these signaling pathways contributes to MASH, NAFLD, IBD, and neurodegenerative disorders, underscoring their relevance as ...
Simone Baldi, Margherita Turrini, Francesco Cei, Marta Menicatti, Gianluca Bartolucci, Amedeo Amedei   +5 more
wiley   +1 more source

Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype [PDF]

, 2014
The aim of the present study was to establish mitochondrial cholesterol trafficking 18 kDa translocator protein (TSPO) as a potential therapeutic target, capable of increasing macrophage cholesterol efflux to (apo)lipoprotein acceptors.
Anne-Marie Allen, Annette Graham, Batarseh, Bird, Borthwick, Borthwick, Brown, Dmitrova-Shumkovska, Engel, Falchi, Farke, Feramisco, Fernandez-Hernando, Gallus, Gerrity, Gut, Hebbachi, Janice M. W. Taylor, Kannel, Khan, Lecanu, Madamanchi, Mercer, Ning, Ning, Ogata, Oram, Pandak, Puddu, Pyper, Rae, Ren, Rigamonti, Rone, Rosenson-Schloss, Rupprecht, Schnoor, Schultz, Taylor, Vanhee, Venkateswaran, Wang, Xu, Yelieev, Zeng, Zeng, Zoltan   +46 more
core   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, Volume 10, Issue 2, 22 January 2026.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

Cholesterolomics: An update [PDF]

, 2017
Cholesterolomics can be regarded as the identification and quantification of cholesterol, its precursors post squalene, and metabolites of cholesterol and of its precursors, in a biological sample.
Alvelius, Alwena H. Morgan, Andersson, Axelson, Bauman, Bazan, Bjorkhem, Bjorkhem, Bjorkhem, Blanc, Byrne, Cobice, Crick, Crick, Davies, de Medina, Diczfalusy, Dzeletovic, Eylan Yutuc, Fakheri, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Gustafsson, Hannedouche, Hu, Ian Gilmore, Ikegami, Jiang, Jiang, Jonas Abdel-Khalik, Klinke, Korade, Kotti, Lehmann, Lin, Liu, Liu, Liu, Maioli, Matysik, Mazzacuva, McDonald, McDonald, McDonald, Myers, Nachtergaele, Nedelcu, Nelson, Novakova, Park, Pataj, Porter, Porter, Radhakrishnan, Reboldi, Roberg-Larsen, Roberg-Larsen, Robertson, Russell, Sacchetti, Saeed, Saeed, Santori, Schroepfer, Setchell, Sever, Shinkyo, Sidhu, Silvente-Poirot, Simigdala, Soncini, Soroosh, Stiles, Theofilopoulos, Theofilopoulos, Thomas Hearn, Wassif, Watabe, William J. Griffiths, Wu, Xu, Yuqin Wang, Zhang   +86 more
core   +1 more source

Pigments, Chromatophore Structure, and Gene Expression Underlying Colour Polytypy of a Panamanian Poison Frog

Molecular Ecology, Volume 35, Issue 1, January 2026.
ABSTRACT Colour polytypism represents an example of phenotypic diversification shaped by genetic divergence and ecological pressures. Poison frogs of the genus Oophaga (Dendrobatidae) are highly polytypic in coloration, making them an ideal system for investigating the genetic and physiological basis of colour variation.
Vasiliki Mantzana‐Oikonomaki, Giselle Tamayo‐Castillo, Víctor Vásquez‐Cháves, Abel Mora‐Machado, William J. Zamora Ramirez, Roberto Ibáñez, Heike Pröhl, Ariel Rodríguez   +7 more
wiley   +1 more source

Antilithiasic effect of β-cyclodextrin in LPN hamster: comparison with cholestyramine

Journal of Lipid Research, 1999
β-Cyclodextrin (BCD), a cyclic oligosaccharide that binds cholesterol and bile acids in vitro, has been previously shown to be an effective plasma cholesterol lowering agent in hamsters and domestic pigs.
Nathalie Boehler, Michel Riottot, Jacqueline Férézou, Maâmar Souidi, Fabien Milliat, Colette Sérougne, Jeffery L. Smith, Claude Lutton   +7 more
doaj   +1 more source

Complex engineering of Solanum alkaloids structural diversity in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 1, Page 328-345, January 2026.
Summary Transient expression in Nicotiana benthamiana offers a powerful and versatile platform for rapid production of complex specialized metabolites. Steroidal glycoalkaloids (SGAs) and steroidal saponins produced by members of the Solanaceae family are known for their diverse structures and activities including antimicrobial, anticancer, antiviral ...
Sachin A. Gharat, Adam Jozwiak, Ilana Rogachev, Elinor A. Sharon, Sagit Meir, Ashok P. Giri, Asaph Aharoni   +6 more
wiley   +1 more source