Results 101 to 110 of about 16,062 (239)

Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration

Journal of Lipid Research, 2003
Although the pool of cholesterol in the adult central nervous system (CNS) is large and of constant size, little is known of the process(es) involved in regulation of sterol turnover in this pool. In 7-week-old mice, net excretion of cholesterol from the
Chonglun Xie, Erik G. Lund, Stephen D. Turley, David W. Russell, John M. Dietschy   +4 more
doaj   +1 more source

Lymphoma and hypercalcemia in a pediatric orthotopic liver transplant patient [PDF]

, 1989
We present a case report of a pediatric orthotopic liver transplant recipient who developed lymphoma with hypercalcemia on cyclosporine and prednisone immunosuppression.
Esquivel, CO, Jaffe, R, Makowka, L, Nakazato, P, Scantlebury, V, Starzl, TE, Urbach, AH   +6 more
core   +1 more source

Conjugated Bile Acids Enhance Growth Performance, Liver Health, and Bile Acid Metabolism in Pearl Gentian Grouper Fed a High Plant‐Protein Diet

Aquaculture Nutrition, Volume 2026, Issue 1, 2026.
The conjugation states of bile acids (BAs) have been demonstrated to affect BAs regulatory functions. This study aimed to investigate the effects of conjugated or non‐conjugated BA additions on growth performance, liver health, and BA metabolism in pearl gentian grouper (Epinephelus lanceolatus♂ × E.
Fan Wang, Fajun Jiang, Jia Xu, Yixin Liang, Xujia Liu, Yichao Li, Junlian Zhuang, Fangjuan Huang, Fu Lei, Chuhang Chen, Ermeng Yu, Junxiang Lai, Xie Shiwei   +12 more
wiley   +1 more source

PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine

Journal of Lipid Research, 2007
Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (
Tiangang Li, Wenling Chen, John Y.L. Chiang   +2 more
doaj   +1 more source

Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis. [PDF]

, 2016
Mycobacterium tuberculosis (Mtb) causes the disease tuberculosis (TB). The virulent Mtb H37Rv strain encodes 20 cytochrome P450 (CYP) enzymes, many of which are implicated in Mtb survival and pathogenicity in the human host.
Abell, Chris, Chenge, Jude, Cortes, Teresa, Driscoll, Max D, Kavanagh, Madeline E, Levy, Colin W, Leys, David, Matak-Vinkovic, Dijana, McLean, Kirsty J, Munro, Andrew W, Rigby, Stephen EJ, Young, Douglas B   +11 more
core   +2 more sources

Emodin Improved the Hepatic Metabolic Dysfunction Induced by High Plant‐Protein Diet in Pengze Crucian Carp (Carassius auratus var. Pengze)

Aquaculture Nutrition, Volume 2026, Issue 1, 2026.
High plant‐protein (HP) diets could induce bile acid (BA) imbalance and lipid metabolism disorder in fish, and emodin supplementation has been reported to increase serum BA levels and improve lipid metabolism with a lack of understanding of its underlying mechanism.
Kaikai Shen, Yongfa Huang, Zhenwei Lu, Jianqin Li, Jingjie Zhang, Ao Luo, Baoqing Hu, Jingen Xu, Jiamin Li, Chungen Wen, Gang Yang, Chuanpeng Zhou   +11 more
wiley   +1 more source

Growth Performance and Intestinal Health of Triploid Rainbow Trout (Oncorhynchus mykiss) Through Bile Acid Supplementation in Low Fishmeal Diets: Insights From Metabolomics, Microbiota, and Gene Expression

Aquaculture Nutrition, Volume 2026, Issue 1, 2026.
This research aimed to explore the impact of bile acid (BA) supplementation in low fishmeal diets on growth performance, serum biochemical indices, tissue morphology, lipid metabolism, gene expression, and gut microbiota in triploid rainbow trout (Oncorhynchus mykiss, initial weight 15.97 ± 1.4 g).
Huamin Wang, Siyuan Liu, Zhenhua Ma, Shidi Wang, Shuze Zhang, Shaoxia Lu, Shicheng Han, Haibo Jiang, Gefeng Xu, Hongbai Liu, Chang’an Wang, Cláudia Aragão   +11 more
wiley   +1 more source

Lipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7α-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes [PDF]

, 1999
Sabine M. Post, Jaap Twisk, Leslie van der Fits, E.C.M. de Wit, Marco F.M. Hoekman, Willem H. Mager, P. Hans   +6 more
openalex   +3 more sources

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

24s-Hydroxycholesterol. Studies on regulatory mechanisms behind its formation in the brain and its potential use as a marker for neurodegeneration [PDF]

, 2010
Cholesterol 24-hydroxylase (CYP46A1) belongs to the cytochrome P450 super family and is responsible for conversion of cholesterol to the oxysterol 24S- hydroxycholesterol (24S-OHC).
Shafaati, Marjan
core