Results 1 to 10 of about 55,642 (178)

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism [PDF]

Nature Communications, 2019
SREBP transcription factors activate lipid synthesis and generate raw materials to lipidate various proteins. Here, the authors show that a stiff cellular environment causes RhoA lipidation and acto-myosin contraction, which inhibits SREBP1 and connects ...
Rebecca Bertolio, Francesco Napoletano, Miguel Mano, Sebastian Maurer-Stroh, Marco Fantuz, Alessandro Zannini, Silvio Bicciato, Giovanni Sorrentino, Giannino Del Sal   +8 more
doaj   +7 more sources

cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1 [PDF]

Journal of Lipid Research, 2013
Diacylglycerol kinase (DGK)θ is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid (PA). We have previously shown that PA is a ligand for the nuclear receptor steroidogenic factor 1 (SF1) and that cAMP-stimulated expression of ...
Kai Cai, Marion B. Sewer
doaj   +5 more sources

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. [PDF]

Nat Commun, 2013
AbstractMicroRNAs (miRs) are small non-protein-coding RNAs that bind to specific mRNAs and inhibit translation or promote mRNA degradation. Recent reports have indicated that miR-33, which is located within the intron of sterol regulatory element-binding protein (SREBP) 2, controls cholesterol homoeostasis and may be a potential therapeutic target for ...
Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K.   +20 more
europepmc   +4 more sources

Leptin Silencing Attenuates Lipid Accumulation through Sterol Regulatory Element-Binding Protein 1 Inhibition in Nasopharyngeal Carcinoma. [PDF]

Int J Mol Sci, 2022
Leptin is a crucial regulator of metabolism and energy homeostasis in mammals. Many studies have investigated the impacts of leptin on human cancers, such as proliferation and metastasis. However, the mechanisms underlying leptin-mediated regulation of lipid metabolism in nasopharyngeal carcinoma (NPC) remain incompletely understood.
Luo SD, Tsai HT, Chiu TJ, Li SH, Hsu YL, Su LJ, Tsai MH, Lee CY, Hsiao CC, Chen CH.   +9 more
europepmc   +3 more sources

Forkhead transcription factor 1 inhibits endometrial cancer cell proliferation via sterol regulatory element-binding protein 1. [PDF]

Oncol Lett, 2017
The morbidity and mortality associated with endometrial cancer (EC) has increased in recent years. Regarded as a tumor suppressor, forkhead transcription factor 1 (FOXO1) has various biological activities and participates in cell cycle progression, apoptosis and differentiation.
Zhang Y, Zhang L, Sun H, Lv Q, Qiu C, Che X, Liu Z, Jiang J.   +7 more
europepmc   +4 more sources

Maturation and activity of sterol regulatory element binding protein 1 is inhibited by acyl-CoA binding domain containing 3. [PDF]

PLoS ONE, 2012
Imbalance of lipid metabolism has been linked with pathogenesis of a variety of human pathological conditions such as diabetes, obesity, cancer and neurodegeneration.
Yong Chen, Vishala Patel, Sookhee Bang, Natalie Cohen, John Millar, Sangwon F Kim   +5 more
doaj   +2 more sources

Fatostatin delayed lip sensory recovery after inferior alveolar nerve transection by inhibiting sterol regulatory element-binding protein 1 [PDF]

Journal of Dental Sciences
Lipid metabolism is essential for nerve repair in damaged nerves. Fatostatin, a selective inhibitor of sterol regulatory element-binding protein 1 (SREBP1), could reduce cholesterol synthesis and disturb lipid homeostasis.
Suning Mao, Zhongkai Ma, Gaowei Zhang, Pingchuan Ma, Chunjie Li, Li Ye   +5 more
doaj   +2 more sources

Discovery of Novel Binders to Sterol Regulatory Element-Binding Protein-1 by High-Throughput Screening. [PDF]

ACS Med Chem Lett
Sterol regulatory element-binding protein-1 (SREBP-1) is a transcription factor that regulates the expression of genes related to fatty acid biosynthesis. Its high expression and activation in obesity and associated metabolic diseases make it a potential therapeutic target.
Maruyama T, Takahashi Y, Hiro K, Murase K, Kojima H, Okabe T, Yamauchi Y, Sato R.   +7 more
europepmc   +3 more sources

Deficiency of glycogen synthase promotes lipid accumulation through ChREBP and AKT-mTOR1-SREBP1 axis activation in mice [PDF]

Journal of Lipid Research
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become highly prevalent worldwide, largely as a consequence of the global obesity epidemic.
Liangkui Li, Jianan Lang, Longyan Yang, Dong Zhao   +3 more
doaj   +2 more sources

Perilipin-mediated lipid droplet formation in adipocytes promotes sterol regulatory element-binding protein-1 processing and triacylglyceride accumulation. [PDF]

PLoS ONE, 2013
Sterol regulatory element-binding protein-1 (SREBP-1) has been thought to be a critical factor that assists adipogenesis. During adipogenesis SREBP-1 stimulates lipogenic gene expression, and peroxisome proliferator-activated receptor γ (PPARγ) enhances ...
Yu Takahashi, Akihiro Shinoda, Norihiko Furuya, Eri Harada, Naoto Arimura, Ikuyo Ichi, Yoko Fujiwara, Jun Inoue, Ryuichiro Sato   +8 more
doaj   +2 more sources