Results 91 to 100 of about 55,660 (196)

Suppressor of Cytokine Signaling-3 (SOCS-3) induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) expression in hepatic HepG2 cell line [PDF]

, 2015
The suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines, including the tumor necrosis factor (TNF-\u3b1).
Corsini, Alberto, Cristofani, Riccardo, Ferri, Nicola, Liu, Jingwen, Macchi, Chiara, Magni, Paolo, Ricci, Chiara, Ruscica, Massimiliano   +7 more
core   +2 more sources

Callose homeostasis at plasmodesmata: molecular regulators and developmental relevance [PDF]

, 2014
Plasmodesmata are membrane-lined channels that are located in the plant cell wall and that physically interconnect the cytoplasm and the endoplasmic reticulum (ER) of adjacent cells.
De Storme, Nico, Geelen, Danny
core   +2 more sources

Effect of organically and conventionally produced diets on jejunal gene expression in chickens [PDF]

, 2010
Using a nutrigenomics approach we studied the response of second-generation chickens at a transcriptional level to organically grown feed ingredients compared with conventionally grown feed ingredients.
Greeff, A., de, Huber, M., Parmentier, H.K., Rebel, J.M.J., Swinkels, W.J.C., Vijver, L.P.L., van de   +5 more
core   +2 more sources

PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity [PDF]

, 2003
PKCλ is implicated as a downstream effector of PI3K in insulin action. We show here that mice that lack PKCλ specifically in the liver (L-λKO mice), produced with the use of the Cre-loxP system, exhibit increased insulin sensitivity as well as a ...
Akimoto Kazunori, Furukawa Kensuke, Hayashi Yoshitake, Hiramatsu Ryuji, Iguchi Haruhisa, Inoue Hiroshi, Kasuga Masato, Matsuki Yasushi, Matsumoto Michihiro, Miyake Kazuaki, Noda Tetsuo, Ogawa Wataru, Ohno Shigeo, Shimano Hitoshi, Yamada Nobuhiro, 山田 信博, 島野 仁   +16 more
core   +1 more source

Heat-treated culture-dried Lactiplantibacillus Plantarum L-14 suppresses adipogenesis and lipogenesis in 3T3-L1 and HepG2 cells

Journal of Functional Foods
Obesity is a growing global health issue prompting the development of probiotic-based interventions. This study investigated whether heat-treated culture-dried L14 (HT-L14) retains these benefits.
Inwook Kim, Soyeong Park, Jieun Kim, Soyeon Kim, Na Rae Hwang, Byeong Soo Eom, Sangkyu Park, Jeongmin Seo   +7 more
doaj   +1 more source

Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity

Journal of Lipid Research, 2006
Fatty acid elongases and desaturases play an important role in hepatic and whole body lipid composition. We examined the role that key transcription factors played in the control of hepatic elongase and desaturase expression.
Yun Wang, Daniela Botolin, Jinghua Xu, Barbara Christian, Ernestine Mitchell, Bolleddula Jayaprakasam, Muraleedharan Nair, Jeffery M. Peters, Julia Busik, L. Karl Olson, Donald B. Jump   +10 more
doaj   +1 more source

The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding [PDF]

, 2013
BACKGROUND: High fat feeding increases hepatic fat accumulation and is associated with hepatic insulin resistance. AMP Activated Protein Kinase (AMPK) is thought to inhibit lipid synthesis by the acute inhibition of glycerol-3-phosphate acyltransferase ...
Bradley S Henriksen, Brandon R Cardon, Chad R Hancock, David M Thomson, Mary E Curtis, Natasha Fillmore   +5 more
core   +1 more source

The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver [PDF]

, 2019
Secreted frizzled-related protein (sFRP) 4 is an adipokine with increased expression in white adipose tissue from obese subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).
Al-Hasani, Hadi, Barbosa, David, Fahlbusch, Pia, Herzfeld de Wiza, Daniella, Hörbelt, Tina, Knebel, Birgit, Kotzka, Jorg, Lapauw, Bruno, Müller-Wieland, Dirk, Ouwens, Margriet, Thoresen, G Hege, Van de Velde, Frederique, Van Nieuwenhove, Yves   +12 more
core   +1 more source

Inhibition of mammalian target of rapamycin complex 1 in the brain microvascular endothelium ameliorates diabetic Aβ brain deposition and cognitive impairment via the sterol-regulatory element-binding protein 1/lipoprotein receptor-associated protein 1 signaling pathway. [PDF]

CNS Neurosci Ther, 2023
Jiang G, Long Z, Wang Y, Wang Y, Xue P, Chen M, Yang K, Li W.   +7 more
europepmc   +1 more source

Targeting CREB3L2-mediated lipid metabolism overcomes lenvatinib resistance and attenuates the progression of hepatocellular carcinoma

Cell Death and Disease
When hepatocellular carcinoma (HCC) cells exhibit malignant biological behaviors, lipid metabolic reprogramming occurs concomitantly. Thus, identifying regulators of metabolic reprogramming offers new potential targets for therapy.
Shiguang Yang, Shaoqing Liu, Jie Li, Shengwei Mao, Qifeng Yu, Xuhui Zhao, Xiaoling Wu, Jiafeng Chen, Yichao Bu, Weiren Liu, Yuan Fang, Yinghong Shi   +11 more
doaj   +1 more source