Results 101 to 110 of about 55,660 (196)

Silencing acetyl-CoA carboxylase A and sterol regulatory element-binding protein 1 genes through RNAi reduce serum and egg cholesterol in chicken. [PDF]

Sci Rep, 2022
Prasad AR, Bhattacharya TK, Chatterjee RN, Divya D, Bhanja SK, Shanmugam M, Sagar NG.   +6 more
europepmc   +1 more source

GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway [PDF]

, 2016
Steroidal glycoalkaloids (SGAs) are cholesterol-derived molecules produced by solanaceous species. They contribute to pathogen defence but are toxic to humans and considered as anti-nutritional compounds.
Aharoni, Asaph, Burdman, Saul, Cárdenas, Pablo D, Dewangan, Veena, Giri, Ashok P, Goossens, Alain, Malitsky, Sergey, Meir, Sagit, Pollier, Jacob, Rogachev, Ilana, Sonawane, Prashant D, Tal, Lior, Vanden Bossche, Robin, Weithorn, Efrat   +13 more
core   +1 more source

ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2

Redox Biology
Macrophage cholesterol homeostasis is crucial for health and disease and has been linked to the lipid-peroxidizing enzyme arachidonate 15-lipoxygenase type B (ALOX15B), albeit molecular mechanisms remain obscure.
Yvonne Benatzy, Megan A. Palmer, Dieter Lütjohann, Rei-Ichi Ohno, Nadja Kampschulte, Nils Helge Schebb, Dominik C. Fuhrmann, Ryan G. Snodgrass, Bernhard Brüne   +8 more
doaj   +1 more source

FGF11 influences 3T3‐L1 preadipocyte differentiation by modulating the expression of PPARγ regulators

FEBS Open Bio, 2019
Fibroblast growth factor 11 (FGF11) is a member of the intracellular fibroblast growth factor superfamily. Here, we identified FGF11 as a novel mediator of adipogenesis.
Kyeong Won Lee, Jae‐Yeon Jeong, Young Jun An, Jung‐Hyun Lee, Hyung‐Soon Yim   +4 more
doaj   +1 more source

Biological Behavior and Lipid Metabolism of Colon Cancer Cells are Regulated by a Combination of Sterol Regulatory Element-Binding Protein 1 and ATP Citrate Lyase. [PDF]

Onco Targets Ther, 2021
Qiu Z, Deng W, Hong Y, Zhao L, Li M, Guan Y, Su Y, Chen C, Shi Q, Yu J, Wang W.   +10 more
europepmc   +1 more source

Changes to cholesterol trafficking in macrophages by Leishmania parasites infection [PDF]

, 2017
Leishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases.
Anderson, Andrade-Neto, Antoine, Bansal, Berman, Blanchette-Mackie, Burack, Carstea, Carvalho, Chakraborty, Chattopadhyay, Collins, Coombs, Coppens, De Cicco, Desvergne, Duclos, Edwards, Ehrenman, Fernandes, Ghosh, Ghosh, Ghosh, Ginger, Ginger, Goldstein, Groener, Hamid, Hart, Ikonen, Infante, Johndrow, Kima, Kima, Kok, Kwon, Lal, Lecoeur, Lippuner, Livak, Majumder, Maxfield, McIntosh, Misslitz, Naureckiene, Neufeld, Osorio y Fortea, Ovalle-Bracho, Paape, Paape, Pereira, Portugal, Pucadyil, Rabhi, Redgrave, Roberts, Rosenzweig, Rub, Russell, Saunders, Sen, Shamshiev, Soares, Sorensen, Tetley, Tewary, Tontonoz, Weinheber   +67 more
core   +2 more sources

Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation [PDF]

, 2018
Elevated O-GlcNAcylation is associated with disease states such as diabetes and cancer. O-GlcNAc transferase (OGT) is elevated in multiple cancers and inhibition of this enzyme genetically or pharmacologically inhibits oncogenesis.
Bacigalupa, Zachary A., Ferrer, Christina M., Gocal, Wiktoria A., Ivan, Mircea, Lee, Joyce V., Mukhopadhyay, Dimpi, Reginato, Mauricio J., Sodi, Valerie L., Wellen, Kathryn E.   +8 more
core   +1 more source

Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase. [PDF]

Bioengineered, 2021
Liu F, Wei J, Hao Y, Lan J, Li W, Weng J, Li M, Su C, Li B, Mo M, Tang F, Wang Y, Yang Y, Jiao W, Qu S.   +14 more
europepmc   +1 more source

Cellular and molecular characterization of the sterol-regulatory element-binding protein-1

, 2004
Human cells maintain lipid homeostasis by regulated cleavage of membranebound transcription factors, so-called sterol-regulatory element-binding proteins (SREBPs). The mature forms of SREBP-1 and -2 are transcriptional activators of lipogenic genes controlling cholesterol, fatty acids, and triglyceride biosynthesis and uptake.
openaire   +3 more sources

The role of NF-Y in the transcriptional regulation of human topoisomerase II¯ : a thesis presented to Massey University in partial fulfilment of the requirement for the degree of Master of Science in Biochemistry [PDF]

, 2001
DNA topoisomerases are ubiquitous enzymes that catalyse reactions that alter the topological state of DNA during the various processes of DNA metabolism including transcription, recombination, replication and chromosome segregation. Human cells exhibit a
Hintz, Patricia Ann
core