Results 171 to 180 of about 55,660 (196)
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Novel roles of sterol regulatory element-binding protein-1 in liver
2016Indiana University-Purdue University Indianapolis (IUPUI) ; Sterol Regulatory Element Binding Protein-1 (SREBP-1) is a conserved transcription factor of the basic helix-loop-helix leucine zipper family (bHLH-Zip) that primarily regulates glycolytic and lipogenic enzymes such as L-pyruvate kinase, acetyl-CoA carboxylase, fatty acid synthase, stearoyl ...
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Journal of Investigative Medicine, 2005
Purpose Increased lipid deposition in skeletal muscle is associated with insulin resistance (IR) and type 2 diabetes (T2DM), but the mechanism is unknown. Sterol regulatory element binding proteins (SREBP) are a family of transcription factors that regulate the biosynthesis of cholesterol and fatty acids.
K. J. Nadeau +3 more
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Purpose Increased lipid deposition in skeletal muscle is associated with insulin resistance (IR) and type 2 diabetes (T2DM), but the mechanism is unknown. Sterol regulatory element binding proteins (SREBP) are a family of transcription factors that regulate the biosynthesis of cholesterol and fatty acids.
K. J. Nadeau +3 more
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Obesity, 2018
ObjectiveAlthough 27‐hydroxycholesterol (27‐HC) has been reported as a potent regulator of lipid homeostasis, its role in hepatic lipogenesis remains obscure. The present study was designed to investigate the impact of 27‐HC on sterol regulatory element‐binding protein 1 (SREBP‐1) and hepatic steatosis.MethodsIn this study, the 27‐HC level in mice was ...
Di Li +4 more
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ObjectiveAlthough 27‐hydroxycholesterol (27‐HC) has been reported as a potent regulator of lipid homeostasis, its role in hepatic lipogenesis remains obscure. The present study was designed to investigate the impact of 27‐HC on sterol regulatory element‐binding protein 1 (SREBP‐1) and hepatic steatosis.MethodsIn this study, the 27‐HC level in mice was ...
Di Li +4 more
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Anti-Cancer Drugs, 2006
"HIV protease-induced lipodystrophy syndrome" is associated with the use of HIV protease inhibitors for treatment of HIV infection. In-vitro studies suggest that alteration of sterol regulatory element binding protein-1 levels underlie its pathogenesis.
Warren A, Chow +2 more
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"HIV protease-induced lipodystrophy syndrome" is associated with the use of HIV protease inhibitors for treatment of HIV infection. In-vitro studies suggest that alteration of sterol regulatory element binding protein-1 levels underlie its pathogenesis.
Warren A, Chow +2 more
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Regulation of sterol regulatory element binding protein-1 in bovine mammary epithelial cells
2016Ph. D.
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