Sterol regulatory element binding protein 1 promotes proliferation and invision of prostate cancer cells [PDF]
Jichu yixue yu linchuangObjective Exploring the expression of sterol regulatory element-binding protein 1 (SREBP1) and acetyl-CoA carboxylase alpha(ACCα) in prostate cancer tissues and their impact on proliferation, migration and invasion of prostate cancer cells DU145 ...
JIANG Hua, ZHANG He, JIANG Songsong
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Cholesterol metabolism is altered in Rett syndrome: A study on plasma and primary cultured fibroblasts derived from patients [PDF]
, 2014 Rett (RTT) syndrome is a severe neurological disorder that affects almost exclusively females. Several detectable mutations in the X-linked methyl-CpG-binding protein 2 gene (MECP2) are responsible for the onset of the disease.
Di Tunno, Ilenia +6 more
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Casein Kinase 1 Regulates Sterol Regulatory Element-binding Protein (SREBP) to Control Sterol Homeostasis [PDF]
Journal of Biological Chemistry, 2014 Sterol homeostasis is tightly controlled by the sterol regulatory element-binding protein (SREBP) transcription factor that is highly conserved from fungi to mammals. In fission yeast, SREBP functions in an oxygen-sensing pathway to promote adaptation to decreased oxygen supply that limits oxygen-dependent sterol synthesis.
Rita T, Brookheart +2 more
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Yin Yang 1 Protein Negatively Regulates High-Density Lipoprotein Receptor Gene Transcription by Disrupting Binding of Sterol Regulatory Element Binding Protein to the Sterol Regulatory Element [PDF]
Endocrinology, 2001 Because the high-density lipoprotein receptor (HDL-R) is a key element in cholesterol homeostasis and a potential therapeutic target for hypercholesterolemic drugs, an understanding of HDL-R regulation is essential. The sterol regulatory element (SRE) binding protein-1a (SREBP-1a) was shown to positively regulate HDL-R gene expression through two SREs.
W, Shea-Eaton, D, Lopez, M P, McLean
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Oleate Potentiates Oxysterol Inhibition of Transcription from Sterol Regulatory Element-1-regulated Promoters and Maturation of Sterol Regulatory Element-binding Proteins [PDF]
Journal of Biological Chemistry, 1998 Activation of genes containing SRE-1 (sterol regulatory element 1) sequences is known to be under the regulation of sterols through modulation of the proteolytic maturation of SREBPs (SRE-1-binding proteins). Previous work has demonstrated SREBP-mediated transcriptional activation of genes encoding enzymes of sterol and fatty acid biosynthesis. Because
Thewke, Douglas P. +2 more
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Effects of Chrysoeriol on Adipogenesis and Lipolysis in 3T3-L1 Adipocytes
Foods, 2022 We examined the effect of chrysoeriol on adipogenesis and lipolysis and elucidated the underlying molecular mechanisms. Chrysoeriol inhibited fat deposition in adipocytes.
Jinhee Song +4 more
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The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells [PDF]
, 2016 The angiogenic inducer CCN1 (Cysteine-rich 61, CYR61) is differentially activated in metastatic breast carcinomas. However, little is known about the precise mechanisms that underlie the pro-metastatic actions of CCN1. Here, we investigated the impact of
Espinoza, Ingrid +3 more
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Journal of Lipid Research, 2006 Insulin induces and dietary n-3 PUFAs suppress hepatic de novo lipogenesis by controlling sterol-regulatory element binding protein-1 nuclear abundance (nSREBP-1). Our goal was to define the mechanisms involved in this regulatory process.
Daniela Botolin +3 more
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Sterol regulatory element binding transcription factor 1 promotes proliferation and migration in head and neck squamous cell carcinoma [PDF]
PeerJ, 2023 Background Sterol-regulatory element-binding protein 1 (SREBP1) is a transcription factor involved in lipid metabolism that is encoded by sterol regulatory element binding transcription factor 1(SREBF1).
Ming Tan +7 more
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Structural basis for sterol sensing by Scap and Insig
Cell Reports, 2021 Summary: The sterol regulatory element-binding protein (SREBP) pathway monitors the cellular cholesterol level through sterol-regulated association between the SREBP cleavage-activating protein (Scap) and the insulin-induced gene (Insig).
Renhong Yan +7 more
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