Results 21 to 30 of about 55,660 (196)

Sterol regulatory element-binding protein 1 is required for ovarian tumor growth

Oncology Reports, 2013
Re-programming of lipogenic signaling is one of the most significant alterations of tumor cell pathology. Consistent with a large demand for lipids, tumor cells express high levels of lipogenic enzymes, most of which are transcriptional targets of sterol regulatory element-binding protein 1 (SREBP1).
Long-Yun, Nie, Qing-Tao, Lu, Wei-Hua, Li, Ning, Yang, Samina, Dongol, Xin, Zhang, Jie, Jiang   +6 more
openaire   +3 more sources

Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate

Lipids in Health and Disease, 2020
Background Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of the lipid metabolism process.
Giovana Rampazzo Teixeira, Leonardo Oliveira Mendes, Allice Santos Cruz Veras, Hayley Hope Allyssa Thorpe, Wagner José Fávaro, Luiz Gustavo de Almeida Chuffa, Patrícia Fernanda Felipe Pinheiro, Francisco Eduardo Martinez   +7 more
doaj   +1 more source

Sterol Regulatory Element-binding Protein-1 Is Regulated by Glucose at the Transcriptional Level [PDF]

Journal of Biological Chemistry, 2000
In vivo studies suggest that sterol regulatory element-binding protein (SREBP)-1 plays a key role in the up-regulation of lipogenic genes in the livers of animals that have consumed excess amounts of carbohydrates. In light of this, we sought to use an established mouse hepatocyte cell line, H2-35, to further define the mechanism by which glucose ...
A H, Hasty, H, Shimano, N, Yahagi, M, Amemiya-Kudo, S, Perrey, T, Yoshikawa, J, Osuga, H, Okazaki, Y, Tamura, Y, Iizuka, F, Shionoiri, K, Ohashi, K, Harada, T, Gotoda, R, Nagai, S, Ishibashi, N, Yamada   +16 more
openaire   +2 more sources

Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein

Journal of Lipid Research, 1998
The current studies define the role of three distinct cis-elements in the proximal promoter of the rat farnesyl diphosphate (FPP) synthase gene. The three cis-elements, a sterol regulatory element 3 (SRE-3) flanked by an ATTGG motif (inverted CCAAT box),
Simon M. Jackson, Johan Ericsson, Roberto Mantovani, Peter A. Edwards   +3 more
doaj   +1 more source

Sterol Regulatory Element-binding Protein (SREBP)-1-mediated Lipogenesis Is Involved in Cell Senescence [PDF]

Journal of Biological Chemistry, 2010
Increased cell mass is one of the characteristics of senescent cells, but this event has not been clearly defined. When subcellular organellar mass was estimated with organelle-specific fluorescence dyes, we observed that most membranous organelles progressively increase in mass during cell senescence.
You-Mie, Kim, Hyun-Taek, Shin, Yong-Hak, Seo, Hae-Ok, Byun, Soo-Han, Yoon, In-Kyu, Lee, Dong-Hoon, Hyun, Hae-Young, Chung, Gyesoon, Yoon   +8 more
openaire   +2 more sources

Maternal betaine suppresses adrenal expression of cholesterol trafficking genes and decreases plasma corticosterone concentration in offspring pullets

Journal of Animal Science and Biotechnology, 2019
Background Laying hens supplemented with betaine demonstrate activated adrenal steroidogenesis and deposit higher corticosterone (CORT) in the egg yolk.
Halima Abobaker, Yun Hu, Nagmeldin A. Omer, Zhen Hou, Abdulrahman A. Idriss, Ruqian Zhao   +5 more
doaj   +1 more source

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. [PDF]

, 2016
Liver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol homeostasis. Under conditions of excess cholesterol, LXR activation induces the expression of several genes involved in cholesterol efflux, facilitates ...
Casero, David, Eskin, Ascia, Gilliland, Thomas, Hong, Cynthia, Jones, Marius C, Katz, Melanie, Lee, Richard, Sallam, Tamer, Sandhu, Jaspreet, Tontonoz, Peter, Vallim, Thomas Q de Aguiar, Whitelegge, Julian, Wu, Xiaohui, Zhang, Li   +13 more
core   +2 more sources

Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF(delta/delta) mouse model of amyotrophic lateral sclerosis [PDF]

, 2010
Background: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that stimulates vasculogenesis. It has also been shown to act as a neurotrophic factor in vitro and in vivo.
Bender, F.L.P., Brockington, A., Carmeliet, P., Claes, F., Heath, P.R., Holden, H., Kasher, P., Lambrechts, D., Sendtner, M., Shaw, P.J.   +9 more
core   +4 more sources

Multiple mechanisms, independent of sterol regulatory element binding proteins, regulate low density lipoprotein gene transcription

Journal of Lipid Research, 2000
Transcription of the LDL receptor gene is markedly enhanced in the Jurkat T cell line by stimulation with the combination of the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the protein synthesis inhibitor cycloheximide (CHX).
Robert S.J. Makar, Peter E. Lipsky, Jennifer A. Cuthbert   +2 more
doaj   +1 more source

A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis

Cancer Communications, 2020
Highly active lipogenesis is essential for rapid tumor growth. Sterol regulatory element‐binding protein (SREBP) is a key transcriptional factor for lipogenesis and activated by reduced sterol and oxysterol levels.
Hongfei Jiang, Lei Zhu, Daqian Xu, Zhimin Lu   +3 more
doaj   +1 more source