Results 41 to 50 of about 55,660 (196)

Mechanisms of sterol regulatory element binding protein‐1 activation by membrane phospholipids

The FASEB Journal, 2013
The sterol regulatory element‐binding protein (SREBP‐1a, ‐1c, and 2) family of transcription factors control genes involved in cholesterol, fatty acid, and triacylglycerol biosynthesis. Misregulation of these genes can contribute to development of the metabolic syndrome. Although cholesterol regulation of SREBP's has been well characterized, regulation
Lorissa Joy Smulan, Amy K. Walker
openaire   +1 more source

Transcription Factor Sterol Regulatory Element Binding Protein 2 Regulates Scavenger Receptor Cla-1 Gene Expression [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2004
Objective—The human scavenger receptor class B type I (Cla-1) plays a key role in cellular cholesterol movement in facilitating transport of cholesterol between cells and lipoproteins. Indirect evidence has suggested thatCla-1gene expression is under the feedback control of cellular cholesterol content.
Tréguier, Morgan, Doucet, Chantal, Moreau, Martine, Dachet, Christiane, Thillet, Joëlle, Chapman, M. John, Huby, Thierry   +6 more
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The mechanism mediating the activation of acetyl-coenzyme A carboxylase-α gene transcription by the liver X receptor agonist T0-901317

Journal of Lipid Research, 2006
In birds and mammals, agonists of the liver X receptor (LXR) increase the expression of enzymes that make up the fatty acid synthesis pathway. Here, we investigate the mechanism by which the synthetic LXR agonist, T0-901317, increases the transcription ...
Saswata Talukdar, F. Bradley Hillgartner
doaj   +1 more source

MIEF2 reprograms lipid metabolism to drive progression of ovarian cancer through ROS/AKT/mTOR signaling pathway

Cell Death and Disease, 2021
MIEF2 (mitochondrial elongation factor 2) is one of the key regulators of mitochondrial fission. Bioinformatics analysis indicated that high expression of MIEF2 predicted a poor prognosis in ovarian cancer patients.
Shuhua Zhao, Lu Cheng, Yuan Shi, Jia Li, Qinghui Yun, Hong Yang   +5 more
doaj   +1 more source

Polyunsaturated Fatty Acids Selectively Suppress Sterol Regulatory Element-binding Protein-1 through Proteolytic Processing and Autoloop Regulatory Circuit [PDF]

Journal of Biological Chemistry, 2010
Sterol regulatory element-binding protein (SREBP)-1 is a key transcription factor for the regulation of lipogenic enzyme genes in the liver. Polyunsaturated fatty acids (PUFA) selectively suppress hepatic SREBP-1, but molecular mechanisms remain largely unknown.
Yoshinori, Takeuchi, Naoya, Yahagi, Yoshihiko, Izumida, Makiko, Nishi, Midori, Kubota, Yuji, Teraoka, Takashi, Yamamoto, Takashi, Matsuzaka, Yoshimi, Nakagawa, Motohiro, Sekiya, Yoko, Iizuka, Ken, Ohashi, Jun-ichi, Osuga, Takanari, Gotoda, Shun, Ishibashi, Keiji, Itaka, Kazunori, Kataoka, Ryozo, Nagai, Nobuhiro, Yamada, Takashi, Kadowaki, Hitoshi, Shimano   +20 more
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Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade

Journal of Lipid Research, 2000
The classic sterol regulatory cis element (sre-1) in the LDL receptor promoter mediates sterol regulatory element binding protein (SREBP)-binding and the effects of insulin and platelet derived growth factor (PDGF).
Jörg Kotzka, Dirk Müller-Wieland, Gunther Roth, Lorena Kremer, Martina Munck, Sandra Schürmann, Birgit Knebel, Wilhelm Krone   +7 more
doaj   +1 more source

Sterol regulatory element-binding proteins are regulators of the rat thyroid peroxidase gene in thyroid cells [PDF]

, 2009
Sterol regulatory element-binding proteins (SREBPs)-1c and -2, which were initially discovered as master transcriptional regulators of lipid biosynthesis and uptake, were recently identified as novel transcriptional regulators of the sodium-iodide ...
Rauer, Christine, Ringseis, Robert, Rothe, Susanne, Wen, Gaiping, Eder, Klaus   +4 more
core   +1 more source

High density lipoprotein inhibits the activation of sterol regulatory element‐binding protein‐1 in cultured cells [PDF]

FEBS Letters, 2010
A link between cellular uptake of high density lipoprotein (HDL) and regulation of sterol regulatory element‐binding protein‐1 (SREBP‐1) was investigated in vitro. HDL decreased nuclear SREBP‐1 levels as well as SREBP‐1 target gene expression in HepG2 and HEK293 cells. However, HDL did not repress an exogenously expressed, constitutively active form of
Yoshida, Masaki, Harada, Nagakatsu, Yoshida, Keiko, Nakagawa, Tadahiko, Shimohata, Takaaki, Mawatari, Kazuaki, Takahashi, Akira, Sakaue, Hiroshi, Nakaya, Yutaka   +8 more
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Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage

Biomedicines, 2022
Glioblastoma (GBM) is the most lethal primary brain tumor. With limited therapeutic options, novel therapies are desperately needed. Recent studies have shown that GBM acquires large amounts of lipids for rapid growth through activation of sterol ...
Yongjun Kou, Feng Geng, Deliang Guo
doaj   +1 more source

Vitamin D. a dynamic molecule. how relevant might the dynamism for a vitamin be [PDF]

, 2015
Cholecalciferol, the precursor of Vitamin D3, is a very old, highly conserved, molecule. Its presence is evident in non-mineralized 750 million-year-old living species, such as plankton.
Mazzaferro, Sandro, Pasquali, Marzia
core   +2 more sources