Results 61 to 70 of about 55,660 (196)

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. [PDF]

, 2018
Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models.
Bahadorani, John, Edillor, Chantle R, Glass, Christopher K, Grossman, Tamar R, Henke, Adam, McDonald, Jeffrey G, Muse, Evan D, Ozeki, Katherine A, Roland, Jason T, Seidman, Jason S, Spann, Nathanael J, Tao, Jenhan, Thompson, Bonne M, Tremblay, Matthew S, Troutman, Ty D, Tsimikas, Sotirios, Yu, Shan   +16 more
core   +1 more source

Resveratrol Inhibits Proliferation and Induces Autophagy by Blocking SREBP1 Expression in Oral Cancer Cells

Molecules, 2022
Resveratrol is a polyphenolic antioxidant found in grapes, red wine, and peanuts and has been reported to have anti-neoplastic effects on various cancer types. However, the exact mechanism of its anti-cancer effects in oral cancer is not fully understood
Masakatsu Fukuda, Yudai Ogasawara, Hiroyasu Hayashi, Katsuyuki Inoue, Hideaki Sakashita   +4 more
doaj   +1 more source

SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait. [PDF]

, 2019
de novo fatty acid biosynthesis (DNFA) is a hallmark adaptation of many cancers that supports survival, proliferation, and metastasis. Here we elucidate previously unexplored aspects of transcription regulation and clinical relevance of DNFA in cancers ...
Näär, Anders M, Wu, Su
core  

Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines [PDF]

, 2006
Objective - Although inflammation is a recognized feature of atherosclerosis, the impact of inflammation on cellular cholesterol homeostasis is unclear.
Ma, KL, Moorhead, JF, Powis, SH, Ruan, XZ, Tao, JL, Varghese, Z, Wheeler, DC   +6 more
core   +1 more source

Phosphorylation and Ubiquitination of the Transcription Factor Sterol Regulatory Element-binding Protein-1 in Response to DNA Binding [PDF]

Journal of Biological Chemistry, 2006
Members of the sterol regulatory element-binding protein (SREBP) family of transcription factors control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation. The transcription factor SREBP1 is degraded by the ubiquitin-proteasome system following phosphorylation of Thr426 and Ser430 in its phosphodegron.
Tanel, Punga, Maria T, Bengoechea-Alonso, Johan, Ericsson   +2 more
openaire   +2 more sources

The site-2 protease [PDF]

, 2002
The site-2 protease (S2P) is an unusually-hydrophobic integral membrane protease. It cleaves its substrates, which are membrane-bound transcription factors, within membrane-spanning helices. Although structural information for S2P from animals is lacking,
Robert B. Rawson, Brown, Wolfe, Rawson, Espenshade, Rawson, Hasan, Rawlings, Zelenski, Rudner, Feng, Zhou, Kinch, Espenshade, DeBose-Boyd, Shen, Seegmiller, Inaba, Ye, Lemberg, Urban, Paetzel, Wang, Lemieux, Ha, Bolter, Seo, Bien, Ye, Zhang, Horton, Radhakrishnan, Sakai, Seidah, Sakai, Duncan, Wang, Schoenheimer, Hasan, Limanek, Evans, Chang, Haze, Hetz, Shen, Kondo, Kondo, Lee, Bailey, Eleveld-Trancikova, Murakami, Murakami, Oeffner, Aten, Xu, Kunte, Matthews, Amarneh, Wang, Pai, Raggo, Lui, Stirling, Ben Aicha, Freeman, Urban, Hannah, Matthews   +67 more
core   +1 more source

Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay [PDF]

Journal of Biological Chemistry, 2001
The reduction in hepatic abundance of sterol regulatory element binding protein-1 (SREBP-1) mRNA and protein associated with the ingestion of polyunsaturated fatty acids (PUFA) appears to be largely responsible for the PUFA-dependent inhibition of lipogenic gene transcription.
J, Xu, M, Teran-Garcia, J H, Park, M T, Nakamura, S D, Clarke   +4 more
openaire   +2 more sources

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology
Lipid metabolism is altered in rapidly proliferating cancer cells, where fatty acids (FAs) are utilized in the synthesis of sphingolipids and glycerophospholipids to produce cell membranes and signaling molecules. Receptor for activated C‐kinase 1 (RACK1;
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
doaj   +1 more source

The zinc cluster protein Sut1 contributes to filamentation in Saccharomyces cerevisiae [PDF]

, 2012
Copyright © 2013, American Society for Microbiology. All Rights ReservedSut1 is a transcriptional regulator of the Zn(II)(2)Cys(6) family in the budding yeast Saccharomyces cerevisiae.
Adamo, Alimardani, Angel Naveenathayalan, Annan, Bandyopadhyay, Borneman, Bourot, Boyce, Burchett, Cook, Costanzo, Cox, Cullen, Cullen, Estruch, Forsberg, Forsburg, Fröhlich, Gimeno, Gollub, Harbison, Heike Unden, Helen A. Foster, Janke, Jin, Lamb, Leberer, Lewis, Lin, Liu, Longtine, Lorenz, MacIsaac, Martínez-Pastor, Matsui, Mingfei Cui, Myers, Ness, O'Rourke, Raitt, Ralf Schwanbeck, Ramer, Roberts, Rupp, Ryan, Régnacq, Sauer, Schjerling, Schmitz, Shapiro, Singh, Thomas Höfken, Tiedje, Tiedje, Wilcox, Zheng, Zhu   +56 more
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Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1 [PDF]

Proceedings of the National Academy of Sciences, 1997
The current studies explore the mechanism by which the sphingomyelin content of mammalian cells regulates transcription of genes encoding enzymes of cholesterol synthesis. Previous studies by others have shown that depletion of sphingomyelin by treatment with neutral sphingomyelinase causes a fraction of cellular cholesterol to translocate
S, Scheek, M S, Brown, J L, Goldstein
openaire   +2 more sources