Results 81 to 90 of about 55,660 (196)

Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1 [PDF]

Journal of Virology, 2012
ABSTRACT Sterol regulatory element binding proteins (SREBPs) are essential transcriptional factors that control expression of lipogenic genes and adipocyte differentiation. Human cytomegalovirus (HCMV) infection has been shown to require the induction of lipogenesis.
Yongjun, Yu, Tobi G, Maguire, James C, Alwine   +2 more
openaire   +2 more sources

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. [PDF]

, 2015
Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown.
Best, A, Caudill, MA, Christensen, KE, Deng, L, Greene, ND, Leung, KY, Lévesque, N, Malysheva, OV, Mikael, LG, Rozen, R, Wu, Q   +10 more
core   +1 more source

Acetyl-CoA Carboxylase β Gene Is Regulated by Sterol Regulatory Element-binding Protein-1 in Liver [PDF]

Journal of Biological Chemistry, 2003
Acetyl-CoA carboxylase (ACC) exists as two major isoforms originated from separate genes: ACCalpha (or ACC1) and ACCbeta (or ACC2). Previous data revealed that ACCbeta has two forms of mRNA with different 5'-untranslated regions derived by different usage of promoters, I and II, in human.
So-Young, Oh, Sahng-Kyoo, Park, Jae-Woo, Kim, Yong-Ho, Ahn, Sahng-Wook, Park, Kyung-Sup, Kim   +5 more
openaire   +3 more sources

Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma

Journal of Lipid Research
Excessive lipid accumulation promotes the occurrence and progression of hepatocellular carcinoma (HCC), accompanied by high levels of fatty acid synthetase (FASN) and more active lipogenesis.
Zihao Deng, Lixia Liu, Guantai Xie, Zhenming Zheng, Jieyou Li, Wenchong Tan, Yaotang Deng, Jinxin Zhang, Manfeng Liang, Yingxia Wu, Zhifeng Zhou, Yan Li, Yukui Chen, Yaling Huang, Hairou Su, Guibing Wu, Xiongjie Shi, Shengpei Cen, Yandan Liao, Yilin Liu, Fei Zou, Xuemei Chen   +21 more
doaj   +1 more source

Regulatory role of isthmin-1 in glucose and lipid metabolism and its clinical implications [PDF]

Jichu yixue yu linchuang
Isthmin-1 (ISM1), a novel adipokine, regulates glucose and lipid metabolism with a tissue-specific manner. In skeletal muscle and adipose tissue, ISM1 activates the insulin-independent mTORC2/PI3K/AKT signaling pathway, promoting GLUT4 translocation to ...
HE Ping, WANG Yan
doaj   +1 more source

Fenofibrate improves renal lipotoxicity through activation of AMPK-PGC-1α in db/db mice. [PDF]

PLoS ONE, 2014
Peroxisome proliferator-activated receptor (PPAR)-α, a lipid-sensing transcriptional factor, serves an important role in lipotoxicity. We evaluated whether fenofibrate has a renoprotective effect by ameliorating lipotoxicity in the kidney. Eight-week-old
Yu Ah Hong, Ji Hee Lim, Min Young Kim, Tae Woo Kim, Yaeni Kim, Keun Suk Yang, Hoon Suk Park, Sun Ryoung Choi, Sungjin Chung, Hyung Wook Kim, Hye Won Kim, Bum Soon Choi, Yoon Sik Chang, Cheol Whee Park   +13 more
doaj   +1 more source

Primate-specific Evolution of an LDLR Enhancer [PDF]

, 2012
Background: Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain.
Boffelli, Dario, Brown, Myles Avery, Chanan, Sumita, Cheng, Jan-Fang, Eisen, Michael B, Moses, Alan M, Prabhakar, Shyam, Rubin, Edward M, Wang, Qian-fei, Wang, Qianben   +9 more
core   +1 more source

Viral hijacking of cellular metabolism. [PDF]

, 2019
This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate.
Ch'ng, James, Christofk, Heather R, Thaker, Shivani K   +2 more
core  

Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function [PDF]

, 2017
It is well established that cholesterol and glycosphingolipids are enriched in the plasma membrane (PM) and form signalling platforms called lipid rafts, essential for T-cell activation and function.
Adlanmerini, Aktas, al Yacoub, Araldi, Ashdown, Balamuth, Bensinger, Bovenga, Brown, Burridge, Chaudhri, Cho, Clark, Daniel, Degroote, Della Torre, Dimeloe, Dunn, Fievet, Foryst-Ludwig, Fox, Gaudet, Gervois, Greenwood, Griffié, Guo, Harris, Herold, Horton, Hughes, Ifergan, Iida, Ikonen, Ishikawa, Ito, Janes, Jeong, Jones, Jury, Jury, Jury, Kanakasabai, Keller, Kidani, Kidani, Kidani, Kirchgessner, Kishimoto, Klein, Kosters, Köberlin, Lappano, Lee, Levental, Levental, Levin, Lingwood, Lisse, Lovett-Racke, Lund, Luquet, Magee, McDonald, Megha, Mesmin, Miguel, Molnár, Nagafuku, Nazarov-Stoica, Ngo, Nuñez, Oliver, Owen, Owen, Pelekanou, Phiel, Quinet, Radhakrishnan, Repa, Rong, Rubin-Delanchy, Sankaran-Walters, Simigdala, Simons, Spann, Steffensen, Sun, Svenson, Swamy, Swinnen, Tang, Tcherepanova, Thangavel, Uppal, Uppal, Varga, Waddington, Waddington, Walcher, Wang, Wang, Wang, Wang, Wang, Wu, Yang, Youssef, Zalba, Zelcer, Zhu   +109 more
core   +2 more sources

Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways [PDF]

, 2018
Scope: To investigate the effect of sulforaphane (SFN) on the abnormal lipid metabolism and underlying mechanisms.  Methods and results: Models with abnormal lipid metabolism were established both in rats and human hepatocytes.
Abu-Elheiga, Acosta-Alvear, Arruda, Baek, Bobrovnikova-Marjon, Choi, Daniels, Fu, Fu, He, Horton, Hu, Jo, Josekutty, Karaskov, Lee, Lee, Lee, Malhotra, Mirmiran, Ntambi, Ota, Oyadomari, Ozcan, Pagliassotti, Puppala, Ron, Shaffer, Shao, Su, Walter, Wen, Yu, Yung, Yung   +34 more
core   +1 more source