Results 121 to 130 of about 63,568 (310)

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Assessing Metabolic and Reproductive Consequences of Prenatal Paracetamol Exposure in Female CD1 Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Paracetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long‐term metabolic and reproductive consequences linked to intrauterine paracetamol exposure.
Bita Entezari, Deniz Bozdag, Elif İnce‐Erguc, Aylin Buhur, Cansin Sirin Tomruk, Suna Sabuncuoglu, Altug Yavasoglu, Hande Gurer‐Orhan   +7 more
wiley   +1 more source

Molluscan Sterols: A Review

, 1972
Many studies on mollusc sterols were made before the advent of modern techniques such as gas chromatography and mass spectrometry, and several structures ascribed to such sterols were incorrect because the preparations lacked homogeneity.The ...
P. Wiseman, D. R. Idler
core   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

The Distribution and Phylogenetic Significance of Desmethylsterols in Chenopodium and Atriplex: Coexistence of Δ7- and Δ5 -sterols

, 1990
Twenty-one species in the Chenopodiaceae were analyzed for sterol composition. In ten of eleven species of Chenopodium, the major desmethylsterols were Δ7-sterols accompanied by lower proportions of Δ5-sterols. In C.
Thomas A. Salt, Patterson, Glenn W., Xu, Sihua, Salt, Thomas A., Kathy M. Schmid, Schmid, Katherine M., Lusby, William R., Sihua Xu, William R. Lusby, Glenn W. Patterson   +9 more
core   +1 more source

Liver Proteomic Alterations Induced by Chronic Fluoride Exposure in Type 2 Diabetic Mice: An Exploratory Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Water fluoridation is recognized as one of the major public health achievements of the 20th century due to its effectiveness in reducing dental caries. Recommended fluoride concentrations in drinking water (0.7–1.5 mgF/L) aim to maximize dental benefits while minimizing adverse effects.
Laura Ribeiro, Heloisa Aparecida Barbosa da Silva Pereira, Juliana Sanches Trevizol, Aislan Quintiliano Delgado, Aline Dionízio, Tamara Teodoro Araujo, Tânia Mary Cestari, José Roberto Bosqueiro, Marília Afonso Rabelo Buzalaf   +8 more
wiley   +1 more source

Sterols and related metabolites from five species of sponges

, 2007
Free sterol fractions were isolated from the marine sponges Phyllospongia madagascarensis, Scalarispongia sp., Oceanapia sp., Monanchora clathrata and studied by GLC, GLC-MS, and spectroscopy NMR. P. madagascarensis and Scalarispongia sp.
Makarieva Tatyana N, Krasokhin Vladimir B, Santalova Elena A, Ponomarenko Ljudmila P, Cimino Guido, Stonik Valentin A, Mollo Ernesto, Denisenko Vladimir A   +7 more
core   +1 more source

Perspectives of High‐Resolution Mass Spectrometry in Soil Science

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Soil biogeochemical research requires specific, sensitive, and accurate methods to identify and quantify organic molecules in order to trace biochemical processes and assess element cycling in complex, heterogenous systems. High‐resolution mass spectrometry (HRMS) has evolved into a transformative tool for unraveling the complex chemical ...
Bruno Glaser, Tobias Bromm, Klaus Kaiser, Arthur Gross, Carsten Simon, Snežana Maletić, Ines Mulder, Oliver J. Lechtenfeld, Sören Thiele‐Bruhn, Ivy Notterpek, Callum Banfield, Michaela A. Dippold   +11 more
wiley   +1 more source

Steroids in porifera. Sterols from freshwater sponges Ephydatia fluviatilis (L.) and Spongilla lacustris (L.) Full Text

, 1988
The sterols of the freshwater sponges E. fluviatilis and S. lacustris were isolated and characterized by reverse-phase HPLC, silver nitrate-silica gel TLC, mass spectrometry, and 1H NMR. E. fluviatilis and S.
Pronzato R., Sica D., PICCIALLI, VINCENZO, Manconi R.   +3 more
core  

Comparison of the dietary and tissue sterols of the greater wax moth, Galleria mellonella (L)

, 1997
The neutral sterols of the greater wax moth Galleria mellonella were determined and compared to the sterols isolated from the used brood comb upon which the insects were reared.
D.J. Harrison, K.R. Wilzer Jr, M.F. Feldlaufer   +2 more
core   +1 more source