Characterization of Xenobiotic and Steroid Disposition Potential of Human Placental Tissue and Cell Lines (BeWo, JEG-3, JAR, and HTR-8/SVneo) by Quantitative Proteomics. [PDF]
Drug Metab Dispos, 2023 The placenta is a fetal organ that performs critical functions to maintain pregnancy and support fetal development, including metabolism and transport of xenobiotics and steroids between the maternal-fetal unit. In vitro placenta models are used to study
Kruger L +11 more
europepmc +2 more sources
A Structural and Bioinformatics Investigation of a Fungal Squalene Synthase and Comparisons with Other Membrane Proteins. [PDF]
ACS Omega, 2022 There is interest in the development of drugs to treat fungal infections due to the increasing threat of drug resistance, and here, we report the first crystallographic structure of the catalytic domain of a fungal squalene synthase (SQS), Aspergillus ...
Malwal SR +7 more
europepmc +2 more sources
Drug screening identifies tazarotene and bexarotene as therapeutic agents in multiple sulfatase deficiency. [PDF]
EMBO Mol Med, 2023 Multiple sulfatase deficiency (MSD, MIM #272200) results from pathogenic variants in the SUMF1 gene that impair proper function of the formylglycine‐generating enzyme (FGE).
Schlotawa L +20 more
europepmc +2 more sources
Steroid sulfatase and sulfotransferases in the estrogen and androgen action of gynecological cancers: current status and perspectives. [PDF]
Essays BiochemSulfatase (STS) and sulfotransferases (SULT) have important role in the biosynthesis and action of steroid hormones. STS catalyzes the hydrolysis of estrone-sulfate (E1-S) and dehydroepiandrosterone-sulfate (DHEA-S), while sulfotransferases catalyze the ...
Rižner TL, Gjorgoska M.
europepmc +2 more sources
Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases. [PDF]
Nat Commun, 2021 Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases longevity. Here we show that loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase (STS), raises the pool of sulfated
Pérez-Jiménez MM +13 more
europepmc +2 more sources
Steroid Sulfatase Stimulates Intracrine Androgen Synthesis and is a Therapeutic Target for Advanced Prostate Cancer. [PDF]
Clin Cancer Res, 2020 Purpose: Most patients with prostate cancer receiving enzalutamide or abiraterone develop resistance. Clinical evidence indicates that serum levels of dehydroepiandrosterone sulfate (DHEAS) and biologically active DHEA remain in the high range despite ...
Armstrong CM +12 more
europepmc +2 more sources
SulfAtlas, the sulfatase database: state of the art and new developments
Nucleic Acids Res., 2022 SulfAtlas (https://sulfatlas.sb-roscoff.fr/) is a knowledge-based resource dedicated to a sequence-based classification of sulfatases. Currently four sulfatase families exist (S1–S4) and the largest family (S1, formylglycine-dependent sulfatases) is ...
M. Stam +5 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2022 The enzyme N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) was originally identified as a lysosomal enzyme which was deficient in Mucopolysaccharidosis VI (MPS VI; Maroteaux-Lamy Syndrome).
J. Tobacman, S. Bhattacharyya
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 Background Sulfatase 2 (SULF2) removes the 6-O-sulfate groups from heparan sulfate proteoglycans (HSPG) and consequently alters the binding sites for various signaling molecules.
Cong-xia Wang +6 more
semanticscholar +1 more source
Proteomic analysis reveals semaglutide impacts lipogenic protein expression in epididymal adipose tissue of obese mice [PDF]
, 2023 Background and objectivesObesity is a global health problem with few pharmacologic options. Semaglutide is a glucagon-like peptide-1 (GLP-1) analogue that induces weight loss. Yet, the role of semaglutide in adipose tissue has not yet been examined.
Ruiyi Zhu +3 more
core +1 more source