Results 21 to 30 of about 7,281 (146)

Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome

JCI Insight, 2021
Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disorder caused by deficiency of the iduronate-2-sulfatase (IDS) enzyme, resulting in cellular accumulation of glycosaminoglycans (GAGs) throughout the body.
A. Arguello, René Meisner, Elliot R. Thomsen, Hoang N. Nguyen, Ritesh Ravi, J. Simms, Iris Lo, Jessica Speckart, Julia Holtzman, T. Gill, D. Chan, Yuhsiang Cheng, Chi‐Lu Chiu, J. Dugas, Meng Fang, Isabel López, Hilda Solanoy, Buyankhishig Tsogtbaatar, Yuda Zhu, Akhil Bhalla, K. Henne, Anastasia G. Henry, Anthony Delucchi, S. Costanzo, Jeffrey M Harris, D. Diaz, K. Scearce-Levie, P. Sanchez   +27 more
semanticscholar   +1 more source

Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling [PDF]

, 2012
Human skin has the capacity to metabolise foreign chemicals (xenobiotics), but knowledge of the various enzymes involved is incomplete. A broad-based unbiased proteomics approach was used to describe the profile of xenobiotic metabolising enzymes present
Cupitt, John, Edwards, Robert J., Fritsche, Ellen, Gierula, Magdalena, Götz, Christine, Rodrigues-Lima, Fernando, van Eijl, Sven, Zhu, Zheying   +7 more
core   +5 more sources

Identification of a Sulfatase that Detoxifies Glucosinolates in the Phloem-Feeding Insect Bemisia tabaci and Prefers Indolic Glucosinolates

Frontiers in Plant Science, 2021
Cruciferous plants in the order Brassicales defend themselves from herbivory using glucosinolates: sulfur-containing pro-toxic metabolites that are activated by hydrolysis to form compounds, such as isothiocyanates, which are toxic to insects and other ...
A. Manivannan, Bhawana Israni, K. Luck, M. Götz, E. Seibel, Michael L. A. E. Easson, Roy Kirsch, M. Reichelt, Beate Stein, S. Winter, J. Gershenzon, D. G. Vassão   +11 more
semanticscholar   +1 more source

Estrogen pathway polymorphisms in relation to primary open angle glaucoma: An analysis accounting for gender from the United States [PDF]

, 2013
Purpose Circulating estrogen levels are relevant in glaucoma phenotypic traits. We assessed the association between an estrogen metabolism single nucleotide polymorphism (SNP) panel in relation to primary open angle glaucoma (POAG), accounting for gender.
Allingham, R. Rand, Bailey, Jessica Cooke, Brilliant, Murray, Budenz, Donald L., Christen, William G., Fingert, John, Friedman, David S., Gaasterland, Douglas, Gaasterland, Terry, Haines, Jonathan L., Hauser, Michael A., Kang, Jae H., Kraft, Peter, Lee, Richard K., Lichter, Paul R., Liu, Yutao, Loomis, Stephanie J., McCarty, Catherine A., Moroi, Sayoko E., Olson, Lana, Pasquale, Louis R., Pericak-Vance, Margaret A., Realini, Tony, Richards, Julia E., Schuman, Joel S., Scott, William K., Singh, Kuldev, Sit, Arthur J., Vollrath, Douglas, Weinreb, Robert N., Wiggs, Janey L., Wollstein, Gadi, Yaspan, Brian L., Zack, Donald J., Zhang, Kang   +34 more
core   +3 more sources

A novel thermostable prokaryotic fucoidan active sulfatase PsFucS1 with an unusual quaternary hexameric structure

Scientific Reports, 2021
Fucoidans are sulfated, fucose-rich marine polysaccharides primarily found in cell walls of brown seaweeds (macroalgae). Fucoidans are known to possess beneficial bioactivities depending on their structure and sulfation degree.
M. Mikkelsen, H. T. Cao, T. Roret, Nanna Rhein-Knudsen, J. Holck, Van Thi Thanh Tran, Thuan Thi Nguyen, V. H. Tran, M. Lezyk, Jan Muschiol, T. D. Pham, M. Czjzek, A. Meyer   +12 more
semanticscholar   +1 more source

The transcriptome of metamorphosing flatfish [PDF]

, 2016
Background Flatfish metamorphosis denotes the extraordinary transformation of a symmetric pelagic larva into an asymmetric benthic juvenile. Metamorphosis in vertebrates is driven by thyroid hormones (THs), but how they orchestrate the cellular ...
Alves, Ricardo N., Clark, M.S., Gomes, Ana S., Power, Deborah M., Reinhard, Richard, Rønnestad, Ivar, Smáradóttir, H., Stueber, Kurt, Thorne, M.A.S., Tine, Mbaye   +9 more
core   +11 more sources

Sulfatase-2 Regulates Liver Fibrosis through the TGF-β Signaling Pathway

Cancers, 2021
Simple Summary Liver fibrosis and/or cirrhosis is a major risk factor for hepatocellular carcinoma. Hepatic Fibrogenesis is the result of an excessive production and deposition of extracellular matrix by hepatic myofibroblasts, which are primarily formed
I. Nakamura, Faizal Z. Asumda, C. Moser, Yoo Na N Kang, Jinping Lai, L. Roberts   +5 more
semanticscholar   +1 more source

A Mapping of Drug Space from the Viewpoint of Small Molecule Metabolism [PDF]

, 2009
Small molecule drugs target many core metabolic enzymes in humans and pathogens, often mimicking endogenous ligands. The effects may be therapeutic or toxic, but are frequently unexpected.
A Ciulli, A Clements, A Schuffenhauer, AC Cheng, AE Cleves, AL Hopkins, AM Nicasio, AP Russ, C James, C Zhang, CM Dobson, D Tondi, DB Kell, DC Chan, Deok-Sun Lee, DJ Payne, DS Lee, DS Lee, E Avdic, E Chu, EC Moore, F Ciruela, F Petit, GV Paolini, Henry F. Chambers, HM Faessel, J Drews, J Hert, JA Kramer, James Corey Adams, JJ McGuire, JP Powell, K Mackay, KF Tipton, KI Goh, LF Shyur, Li Basuino, M Johnson, MA Bogoyevitch, MA Yildirim, MB Navarro, Michael J. Keiser, MJ Keiser, MP Costi, MV Dias, NC Meisner, Olaf G. Wiest, P Imming, P Romero, P Shannon, P Willett, Patricia C. Babbitt, Philip E. Bourne, PJ Hajduk, R Caspi, R Martin, RL Kisliuk, S Ekins, S Rochfort, SF Altschul, SM Watkins, W Lewis, W Lewis, WH Gmeiner, Y Cho, Y Yamanishi   +65 more
core   +3 more sources

Congenital Ichthyoses: 11 Cases from the Pediatric Dermatology Multidisciplinary Consultation of the Centro Hospitalar e Universitário de Lisboa Central [PDF]

, 2019
Introdução: As ictioses são um grupo heterogéneo de distúrbios genéticos hereditários que ocorrem devido a um defeito da queratinização e consequente disrupção da função de barreira cutânea.
Borges, Ana Sofia, Brasileiro, Ana, Cordeiro, A., Paiva Lopes, Maria João   +3 more
core   +2 more sources

Molecular mechanisms related to hormone inhibition resistance in prostate cancer [PDF]

, 2019
Management of metastatic or advanced prostate cancer has acquired several therapeutic approaches that have drastically changed the course of the disease.
Cheng L., Cimadamore A., Di Nunno V., Lopez-Beltran A., Massari F., Mollica V., Montironi R., Santoni M., Scarpelli M.   +8 more
core   +1 more source