Results 31 to 40 of about 7,281 (146)

TOWARDS UNDERSTANDING MODE-OF-ACTION OF TRADITIONAL MEDICINES BY USING IN SILICO TARGET PREDICTION [PDF]

, 2018
Traditional medicines (TM) have been used for centuries to treat illnesses, but in many cases their modes-of-action (MOAs) remain unclear. Given the increasing data of chemical ingredients of traditional medicines and the availability of large-scale ...
BINTI MOHAMAD ZOBIR, SITI ZURAIDAH
core   +1 more source

Transmembrane protein topology prediction using support vector machines [PDF]

, 2009
Background: Alpha-helical transmembrane (TM) proteins are involved in a wide range of important biological processes such as cell signaling, transport of membrane-impermeable molecules, cell-cell communication, cell recognition and cell adhesion.
A Krogh, A Kyttälä, A Lo, B Boeckmann, B Rost, BW Matthews, C Pasquier, CP Chen, D Perlman, DA Benson, David T Jones, DT Jones, DT Jones, E Granseth, E Wallin, E Wong, G Gafvelin, G Lasso, G von Heijne, G von Heijne, GE Tusnady, GE Tusnády, GE Tusnády, H Viklund, H Viklund, H Viklund, H Viklund, HM Berman, HR Petty, JD Bendtsen, JM Cuthbertson, K Melén, L Käll, L Käll, M Amico, M Hedman, MA Lomize, O Emanuelsson, P Flicek, PG Bagos, PG Bagos, PL Martelli, Q Mao, S Abe, S Jayasinghe, S Möller, S White, SF Altschul, T Hirokawa, T Joachims, TA Larsson, Timothy Nugent, V Vapnik, Y Chen, Y Liu, Y Liu   +55 more
core   +4 more sources

Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions [PDF]

, 2012
The biological mechanisms underlying castration resistance of prostate cancer are not fully understood. In the present study, we examined the role of organic anion transporting polypeptides (OATPs) as importers of dehydroepiandrosterone sulfate (DHEAS ...
Arakawa Hiroshi, Kawai Keiichi, Mizokami Atsushi, Nakanishi Takeo, Nishimoto Tomohiro, Tamai Ikumi, Wakayama Tomohiko, Yanagihara Chihiro   +7 more
core   +2 more sources

Estrone Sulfatase Inhibitors as New Anticancer Agents [PDF]

, 2019
Enzyme steroid sulfatase (STS) is considered as a promising therapeutic target for the treatment of hormone-dependent oncological diseases such as breast, endometrial, prostate cancers, and endometriosis.
Morozkina, Svetlana N., Shavva, Alexander G.   +1 more
core   +1 more source

Sulfatase-cleavable linkers for antibody-drug conjugates†

Chemical Science, 2020
Antibody-drug conjugates (ADCs) are a class of targeted drug delivery agents combining the cell-selectivity of monoclonal antibodies (mAbs) and the cytotoxicity of small molecules.
Jonathan D Bargh, Stephen J. Walsh, Albert Isidro-Llobet, Soleilmane Omarjee, J. Carroll, D. Spring   +5 more
semanticscholar   +1 more source

Multiple Sulfatase Deficiency: A Disease Comprising Mucopolysaccharidosis, Sphingolipidosis, and More Caused by a Defect in Posttranslational Modification

International Journal of Molecular Sciences, 2020
Multiple sulfatase deficiency (MSD, MIM #272200) is an ultra-rare disease comprising pathophysiology and clinical features of mucopolysaccharidosis, sphingolipidosis and other sulfatase deficiencies. MSD is caused by impaired posttranslational activation
Lars Schlotawa, L. Adang, Karthikeyan Radhakrishnan, Rebecca C. Ahrens-Nicklas   +3 more
semanticscholar   +1 more source

Producción científica institucional y posicionamiento nacional: el caso del Hospital General de México [PDF]

, 2004
The purpose of this work was to identify the scientific output, position and visibility of Mexico’s General Hospital (Hospital General de México-HGM).
Gutiérrez-Carrasco, A., Macías-Chapula, C. A., Mendoza-Guerrero, J. A., Rodea-Castro, I. P.   +3 more
core   +2 more sources

Unravelling the genetic and molecular mechanisms of the left-right patterning genes Pkd1l1 and Pkd2 [PDF]

, 2023
Pkd1 and Pkd2 encode the polycystin proteins which underlie human ADPKD, a major cause of end stage renal failure. Recently, by analysing the Pkd2lrm4 mouse, a previous member of the lab provided evidence that loss of ciliary PKD2 underlies kidney cyst ...
Dyer, Laura
core   +2 more sources

Multiple sulfatase deficiency

Atlas of Inherited Metabolic Diseases, 2020
The neonatal type is the most severe form, with signs and symptoms appearing soon after birth. Affected individuals have deterioration of tissue in the nervous system (leukodystrophy), which can contribute to movement problems, seizures, developmental ...
Christian Staufner
semanticscholar   +1 more source

Natural history of multiple sulfatase deficiency: Retrospective phenotyping and functional variant analysis to characterize an ultra‐rare disease

Journal of Inherited Metabolic Disease, 2020
Multiple sulfatase deficiency (MSD) is an ultra‐rare neurodegenerative disorder caused by pathogenic variants in SUMF1. This gene encodes formylglycine‐generating enzyme (FGE), a protein required for sulfatase activation.
L. Adang, Lars Schlotawa, S. Groeschel, C. Kehrer, K. Harzer, O. Staretz-Chacham, T. O. Silva, I. Schwartz, J. Gärtner, Mauricio J De Castro, Carrie E Costin, Esperanza Font Montgomery, T. Dierks, Karthikeyan Radhakrishnan, Rebecca C. Ahrens-Nicklas   +14 more
semanticscholar   +1 more source