The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels
Toxins, 2016 The bovine pancreatic trypsin inhibitor (BPTI)-Kunitz-type protein ShPI-1 (UniProt: P31713) is the major protease inhibitor from the sea anemone Stichodactyla helianthus.
Rossana García-Fernández +6 more
doaj +1 more source
Friends or Foes? Emerging Impacts of Biological Toxins [PDF]
, 2019 Toxins are substances produced from biological sources (e.g., animal, plants, microorganisms) that have deleterious effects on a living organism. Despite the obvious health concerns of being exposed to toxins, they are having substantial positive impacts
Casewell, N.R. +6 more
core +6 more sources
Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK
Marine Drugs, 2015 ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca. 16 pM.
Michael W. Pennington +7 more
doaj +1 more source
Proteins: Structure, Function, and Bioinformatics, Volume 92, Issue 2, Page 192-205, February 2024.Abstract Diverse structural scaffolds have been described in peptides from sea anemones, with the ShKT domain being a common scaffold first identified in ShK toxin from Stichodactyla helianthus. ShK is a potent blocker of voltage‐gated potassium channels (KV1.x), and an analog, ShK‐186 (dalazatide), has completed Phase 1 clinical trials in plaque ...
Karoline Sanches +9 more
wiley +1 more source
Mitochondrial Group I Introns in Hexacorals Are Regulatory Genetic Elements [PDF]
, 2020 Hexacoral mitochondrial genomes are highly economically organized and vertebrate-like in size, structure, and gene content. A hallmark, however, is the presence of group I introns interrupting essential oxidative phosphorylation (OxPhos) genes. Two genes,
Emblem, Åse, Johansen, Steinar Daae
core +2 more sources
Review of sea anemones compound and bioactivity [PDF]
, 2013 海葵(sea anemone)又名海菊花,多指腔肠动物门(Coelenterata)珊瑚虫纲(Anthozoa)海葵目(actiniaria)动物。海葵一般分为爱氏海葵科、链索海葵科、细指海葵科、投海葵科、固边海葵科和绿海葵科等6科37种[1]。海葵体型大多呈圆筒状,触手以辐射对称状在口周围形成数轮,广泛分布在热带和温热带海域,主要固着在海中岩石上或泥沙中 ...
史文军, 吴建平, 张朝晖, 秦松
core
COELENTERATE TOXINS, ITS PHARMACEUTICAL AND THERAPEUTIC EFFECTS [PDF]
, 2021 Present review article emphasizes species specific coelenterate toxins, its pharmaceutical and therapeutic effects. Most of the coelenterates inflict venom accidently by using nematocysts found on arms.
SHARMA, SIMRAN, UPADHYAY, RAVI KANT
core +1 more source
Sticholysin, Sphingomyelin, and Cholesterol: A Closer Look at a Tripartite Interaction [PDF]
, 2019 Actinoporins are a group of soluble toxic proteins that bind to membranes containing sphingomyelin (SM) and oligomerize to form pores. Sticholysin II (StnII) is a member of the actinoporin family, produced by Stichodactyla helianthus.
García Linares, Sara +5 more
core +2 more sources
Biochemical evidences for M1-, M17- and M18-like aminopeptidases in marine invertebrates from Cuban coastline [PDF]
, 2020 Metallo-aminopeptidases (mAPs) control many physiological processes. They are classified in different families according to structural similarities. Neutral mAPs catalyze the cleavage of neutral amino acids from the N-terminus of proteins or peptide ...
Alvarez Lajonchere, L. (Luis) +8 more
core +1 more source
Bases moleculares de la interacción esticolisina-membrana sobre la estructura del poro y los efectos de los lípidos. [PDF]
, 2021 Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Químicas, leída el 18/06/2021The usefulness of toxicity across the tree of life is far beyond doubt. Most, if not all, organisms produce compounds that can be used for attack and/
Palacios Ortega, Juan
core +1 more source