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Health Benefits and Pharmacological Properties of Stigmasterol

Antioxidants, 2022
Stigmasterol is an unsaturated phytosterol belonging to the class of tetracyclic triterpenes. It is one of the most common plant sterols, found in a variety of natural sources, including vegetable fats or oils from many plants.
Saad Bakrim, Nesrine Benkhaira, Ilhame Bourais, Taoufiq Benali, Learn-Han Lee, Nasreddine El Omari, Ryan A. Sheikh, Khang Wen Goh, Long Chiau Ming, Abdelhakim Bouyahya   +9 more
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Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor

Pharmaceutical Biology, 2023
Context Stigmasterol has significant anti-arthritis and anti-inflammatory effects, but its role in immune and inflammatory diseases is still unclear.Objective The potential advantages of stigmasterol in asthma were explored in IL-13-induced BEAS-2B cells
Jimei Zhang, Chonghong Zhang, Li Miao, Zimin Meng, Ning Gu, Guifang Song   +5 more
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In vitro cytotoxic effect of stigmasterol derivatives against breast cancer cells

BMC Complementary Medicine and Therapies, 2023
Background Stigmasterol is an unsaturated phytosterol that belong to the class of tetracyclic steroids abundant in Rhoicissus tridentata. Stigmasterol is an important constituent since it has shown impressive pharmacological effects such as anti ...
Nondumiso Premilla Dube, Vuyelwa Jacqueline Tembu, Getrude R Nyemba, Candace Davison, Goitsemodimo Herckious Rakodi, Douglas Kemboi, Jo-Anne de la Mare, Xavier Siwe-Noundou, Amanda-Lee Ezra Manicum   +8 more
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Advances in Stigmasterol on its anti-tumor effect and mechanism of action

Frontiers in Oncology, 2022
Stigmasterol is a phytosterol derived from multiple herbaceous plants such as herbs, soybean and tobacco, and it has received much attention for its various pharmacological effects including anti-inflammation, anti-diabetes, anti-oxidization, and ...
Xiaoyu Zhang, Jiayun Wang, Lin Zhu, Xuezhen Wang, Feifei Meng, Lei Xia, Hairong Zhang   +6 more
doaj   +2 more sources

Stigmasterol Restores the Balance of Treg/Th17 Cells by Activating the Butyrate-PPARγ Axis in Colitis

Frontiers in Immunology, 2021
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with gut microbiota disequilibrium and regulatory T (Treg)/T helper 17 (Th17) immune imbalance. Stigmasterol, a plant-derived sterol, has shown anti-inflammatory effects. Our study aimed
Shuting Wen, Long He, Zhuotai Zhong, Runyuan Zhao, Senhui Weng, Hong Mi, Fengbin Liu, Fengbin Liu, Fengbin Liu   +8 more
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Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction

Pharmaceutics, 2020
Background: Phytosterols have physiological effects and are used as medicines or food supplements. Stigmasterol has shown anticancer effects against various cancers such as hepatoma, cholangiocarcinoma, gall bladder carcinoma, endometrial adenocarcinoma ...
Hyocheol Bae, Gwonhwa Song, Whasun Lim
doaj   +2 more sources

Structure and Properties of Organogels Prepared from Rapeseed Oil with Stigmasterol

Foods, 2022
This work used the natural ingredient stigmasterol as an oleogelator to explore the effect of concentration on the properties of organogels. Organogels based on rapeseed oil were investigated using various techniques (oil binding capacity, rheology ...
Caili Tang, Zheng Wan, Yilu Chen, Yiyun Tang, Wei Fan, Yong Cao, Mingyue Song, Jingping Qin, Hang Xiao, Shiyin Guo, Zhonghai Tang   +10 more
doaj   +2 more sources

Anti-diabetic Potential of a Stigmasterol From the Seaweed Gelidium spinosum and Its Application in the Formulation of Nanoemulsion Conjugate for the Development of Functional Biscuits

Frontiers in Nutrition, 2021
The seaweed Gelidium spinosum was selected for the extraction of phytosterol by the Soxhlet method. The extracted phytosterol was chemically characterized as stigmasterol using Fourier-transform infrared spectrometry and gas chromatography–mass ...
Navya Poulose, Arya Sajayan, Amrudha Ravindran, Ambili Chandran, G. Balasubramanian Priyadharshini, Joseph Selvin, G. Seghal Kiran   +6 more
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Mechanisms and Neuroprotective Activities of Stigmasterol Against Oxidative Stress-Induced Neuronal Cell Death via Sirtuin Family

Frontiers in Nutrition, 2021
Background: Accumulating studies have confirmed that oxidative stress leads to the death of neuronal cells and is associated with the progression of neurodegenerative diseases, including Alzheimer's disease (AD). Despite the compelling evidence, there is
Reny Pratiwi, Reny Pratiwi, Chanin Nantasenamat, Waralee Ruankham, Wilasinee Suwanjang, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin, Kamonrat Phopin   +8 more
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Antimicrobial Activities of Stigmasterol from Piper crocatum In Vitro and In Silico

Journal of Chemistry
The high incidence of oral health issues and antibiotic resistance has stimulated research into discovering novel antimicrobial drugs. Prior evidence suggests that red betel leaves (Piper crocatum Ruiz and Pav) possess potential antimicrobial properties,
Seftiana Lestari, Dikdik Kurnia, Tri Mayanti, Leny Heliawati   +3 more
doaj   +2 more sources