Results 91 to 100 of about 61,886,207 (255)
Exploration, EarlyView.This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi +5 more
wiley +1 more source
Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers [PDF]
, 2003 Background/Aim: N-6 fatty acids are considered to promote diseases prevalent in industrialized countries and characterized by an increased eicosanoid biosynthesis from arachidonic acid (AA).
Zöllner, N., Adam, Olaf, Wolfram, G.
core +1 more source
Thiol dependent isomerization of all-trans-retinoic acid to 9-cis-retinoic acid [PDF]
, 1994 The important biological effector 9-cis-retinoic acid can be generated by liver microsomes or by bovine serum albumin in detergent. The mechanism of this isomerization reaction is the subject of these studies.
Urbach, Jonathan +3 more
core +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
International Journal of Nanomedicine, 2023 Ming-Jun Tsai,1,2 Cheng-Yu Lin,3 Jiří Trousil,4 Calvin T Sung,5 Mei-Hua Lee,3 Jia-You Fang,3,6,7 Shih-Chun Yang8 1School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; 2Jhong Siao Urological Hospital, Kaohsiung, Taiwan ...
Tsai MJ +6 more
doaj
Differential Regulation of Tyrosinase Activity in Skin of White and Black Individuals In Vivo by Topical Retinoic Acid [PDF]
, 1993 Tyrosinase activity is a key determinant of melanin production in skin. Because retinoic acid regulates tyrosinase activity in melanoma cells, we analyzed modulation of pigmentation in vivo by retinoic acid.
Gary J. Fisher +13 more
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Journal of Surfactants and Detergents, EarlyView.ABSTRACT Striae distensae are common dermal lesions that negatively affect skin appearance, and topical management remains limited by challenges related to skin deposition and residence time. Here, we developed transparent surfactant‐based isotropic systems for the topical co‐delivery of ascorbic acid (AA), retinoic acid (RA), and lavender essential ...
Claudiane Ayres Prochno +8 more
wiley +1 more source
Discovery of new therapeutic targets in Neuroblastoma by means of proteomic approach and functional studies [PDF]
, 2010 Neuroblatoma (NB) is an embryonal tumor of the sympathetic nervous system which arises from the neural crest cells. This disease rappresents the most common extracranial tumor in infants, accounting for 8% to 10% of all childhood cancer and for ...
Cimmino, Flora
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Analysis of connexin43 gene expression induced by retinoic acid in F9 teratocarcinoma cells [PDF]
, 1996 All-trans retinoic acid (10−7 M) induces cell-cell communication and expression of the gap junction protein connexin43 in mouse F9 teratocarcinoma cells.
Sies, Helmut +5 more
core +1 more source
Enterovirus infections in children
Pediatric Investigation, EarlyView.Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen +11 more
wiley +1 more source