Results 101 to 110 of about 61,886,207 (255)

The PML-RAR alpha transcript in long-term follow-up of acute promyelocytic leukemia patients [PDF]

, 2001
Background and Objectives. Detection of PML-RAR alpha transcripts by RT-PCR is now established as a rapid and sensitive method for diagnosis of acute promyelocytic leukemia (APL), Although the majority of patients in longterm clinical remission are ...
Gameiro, P, Diamond, J, Foroni, L, Silva, AL, Mehta, AB, Prentice, HG, Carrara, P, Vieira, S, Guimaraes, JE, Parreira, A, Hoffbrand, AV, de Sousa, AB   +11 more
core  

Evolution of the role of RA and FGF signals in the control of somitogenesis in chordates [PDF]

, 2015
The laboratory of HE is supported by the ANR BLAN 1716 01. IMLS´s laboratory is currently supported by MASTS (Marine Alliance for Science and Technology Scotland).During vertebrate development, the paraxial mesoderm becomes segmented, forming somites ...
Angel R de Lera, Lucie Subirana, Silvan Oulion, Ildiko Somorjai, Daniel Aldea, Subirana, Lucie, Oulion, Silvan, Aldea, Daniel, Escriva, Hector, Stéphanie Bertrand, Somorjai, Ildiko, Hector Escriva, de Lera, Angel R., Bertrand, Stéphanie, Somorjai, Ildiko Maureen Lara   +14 more
core   +2 more sources

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

Regulation of Neurotrophic Factor Expression in Nerve Cells and Intervertebral Disk Cells by Inflammatory Cytokines, Implications for Pain Pathways

Global Spine Journal, 2012
Introduction Intervertebral disk (IVD) degeneration and prolapse contribute significantly to low back pain and sciatica cases. Within the IVD, the nucleus pulposus cells are known to produce a number of catabolic cytokines which have been shown to elicit
S. Thomas, R. Colletta, K. L. Phillips, N. Chiverton, A. Cross, C. L. Le Maitre   +5 more
doaj   +1 more source

Regulatory NLRs Control the RLR-Mediated Type I Interferon and Inflammatory Responses in Human Dendritic Cells

Frontiers in Immunology, 2018
Unique members of the nucleotide-binding domain leucine-rich repeat (NLR) family have been found to regulate intracellular signaling pathways initiated by other families of pattern recognition receptors (PRR) such as Toll-like receptors (TLRs) and ...
Tünde Fekete, Dora Bencze, Attila Szabo, Eszter Csoma, Tamas Biro, Attila Bacsi, Kitti Pazmandi   +6 more
doaj   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Innate immune recognition and evasion strategies of hepatitis B virus: from DNA to RNA and viral proteins

Frontiers in Immunology
Innate immunity constrains the hepatitis B virus (HBV) by sensing pathogen-associated molecular patterns (PAMPs) and inducing type I/III interferons and interferon-stimulated genes.
Zhenghao Chen, Zhenghao Chen, Rui Hu, Huajun Ye, Qiuxun Chen, Yuhang Liu, Xinyu Zhang, Yingting Chen, You Wu, Ciliang Jin   +9 more
doaj   +1 more source

Inhibition of Hamster Tongue Carcinogenesis by Selenium and Retinoic Acid

, 1986
The inhibitory effect of selenium, 13-cis-retinoic acid, and their combination was studied in an animal model in which squamous cell carcinoma of the tongue was induced by 0.5% 9,10 dimethyl-1,2 benzanthracene (DMBA). A controlled, blinded experiment was
Goodwin, W. Jarrard, Huijing, Frans, Altman, Norman, Bordash, Gerard D   +3 more
core   +1 more source

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes [PDF]

, 2015
This study was supported by funding from the UK Biotechnology and Biological Sciences Research Council Diet and Health Research Industry Club (BBSRC-DRINC) (BB/I006028/1) and by a studentship grant (BB/J500100/1).Scope: Flavonoids are generally studied ...
Kerr, J.S., Zhang, Q., O'Hagan, David, Kerr, Jason, Kay, C.D., Maria A. O'Connell, Sai Krishna Yalamanchili, Raheem, S., David O'Hagan, Colin D. Kay, O'Connell, M.A., O'Hagan, D., di Gesso, J.L., Kay, Colin, Jason S. Kerr, Saki Raheem, Zhang, Qingzhi, Krishna Yalamanchili, Sai, O’Hagan, D., Di Gesso, Jessica, O'Connell, Maria, Raheem, Saki, Yalamanchili, S.K., Jessica L. di Gesso, Qingzhi Zhang   +24 more
core   +1 more source

Type I interferon overactivation in sera of patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease

Rheumatology &Autoimmunity, EarlyView.
Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura, Yasuhiro Katsumata, Yuko Okamoto, Masayoshi Harigai   +3 more
wiley   +1 more source