Results 31 to 40 of about 61,886,207 (255)

Follicle-stimulating hormone (FSH) promotes retinol uptake and metabolism in the mouse ovary

Reproductive Biology and Endocrinology, 2018
Background Retinoids (retinol and its derivatives) are required for the development and maintenance of normal physiological functions of the ovary.
Zhuo Liu, Yongfeng Sun, Yanwen Jiang, Yuqiang Qian, Shuxiong Chen, Shan Gao, Lu Chen, Chunjin Li, Xu Zhou   +8 more
doaj   +1 more source

A deficient immune response to SARS-CoV-2 in the nasopharynx is associated with severe COVID-19 pneumonia

International Journal of Infectious Diseases, 2023
Objectives: We analyzed the expression of inflammatory and antiviral genes in the nasopharynx of SARS-CoV-2 infected patients and their association with the severity of COVID-19 pneumonia.
Carlos Pita-Martínez, Felipe Pérez-García, Ana Virseda Berdices, María Martin-Vicente, Lucía Castilla-García, Irene Hervás Fernández, Victoria González Ventosa, María José Muñoz-Gómez, Juan Cuadros-González, Jesús F Bermejo-Martin, Salvador Resino, Isidoro Martínez   +11 more
doaj   +1 more source

The sodium iodide symporter (NIS) and potential regulators in normal, benign and malignant human breast tissue.

PLoS ONE, 2011
IntroductionThe presence, relevance and regulation of the Sodium Iodide Symporter (NIS) in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators in human breast tissue, with ...
James Ryan, Catherine E Curran, Emer Hennessy, John Newell, John C Morris, Michael J Kerin, Roisin M Dwyer   +6 more
doaj   +1 more source

To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses. [PDF]

PLoS ONE, 2013
Our earlier study revealed that STRA6 (stimulated by retinoic acid gene 6) was up-regulated within 3 h of TCR stimulation. STRA6 is the high-affinity receptor for plasma retinol-binding protein (RBP) and mediates cellular vitamin A uptake.
Rafik Terra, Xuehai Wang, Yan Hu, Tania Charpentier, Alain Lamarre, Ming Zhong, Hui Sun, Jianning Mao, Shijie Qi, Hongyu Luo, Jiangping Wu   +10 more
doaj   +1 more source

Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical- and toxin-induced neurotoxicity

BMC Pharmacology and Toxicology, 2017
Background Exposure to chemicals might be toxic to the developing brain. There is a need for simple and robust in vitro cellular models for evaluation of chemical-induced neurotoxicity as a complement to traditional studies on animals.
Dina Popova, Jessica Karlsson, Stig O. P. Jacobsson   +2 more
doaj   +1 more source

Ornithine decarboxylase, polyamines and CD11b expression in HL-60 cells during differentiation induced by retinoic acid.

, 2004
Polyamines (PA) and retinoic acid affect mammalian cell growth, differentiation and apoptosis. Retinoic acid induces granulocytic differentiation of mieloid cell lines and, during this process, is responsible for the expression of CD11b, a surface ...
CARAMELLI E, CARAMELLI, ELISABETTA, BARONI T, CALASTRINI C, BRUGNOLI F, BRUGNOLI, Federica, PELLATI, Agnese, CALASTRINI, Carla, BERTAGNOLO, Valeria, MARINUCCI L, VERTEMATI M, BERTAGNOLO V., STABELLINI G, PELLATI A, STABELLINI, Giordano, VIZZOTTO L   +15 more
core   +2 more sources

Vitamin A deficiency attenuates cardiac rupture in Stra6-deficient hearts following ischemic injury

Frontiers in Cardiovascular Medicine
BackgroundStimulated by retinoic acid gene 6 (STRA6) is a cell surface receptor that regulates cellular uptake of vitamin A metabolites and cardiac development.
Yannick Smolenski, Natali Froese, Paolo Galuppo, Christopher Werlein, Anna Gigina, Steven R. Talbot, Sergej Erschow, Dirk Wedekind, Robert Geffers, Norbert B. Ghyselinck, Heike Bähre, Jan C. Kamp, Jan C. Kamp, Lavinia Neubert, Lavinia Neubert, Melanie Ricke-Hoch, Johann Bauersachs, Christian Riehle   +17 more
doaj   +1 more source

Senecavirus A-induced glycolysis facilitates virus replication by promoting lactate production that attenuates the interaction between MAVS and RIG-I.

PLoS Pathogens, 2023
Senecavirus A (SVA)-induced porcine idiopathic vesicular disease has caused huge economic losses worldwide. Glucose metabolism in the host cell is essential for SVA proliferation; however, the impact of the virus on glucose metabolism in host cells and ...
Huizi Li, Cunhao Lin, Wenbao Qi, Zhenzhen Sun, Zhenxin Xie, Weixin Jia, Zhangyong Ning   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Immunobiotic Strains Modulate Toll-Like Receptor 3 Agonist Induced Innate Antiviral Immune Response in Human Intestinal Epithelial Cells by Modulating IFN Regulatory Factor 3 and NF-κB Signaling

Frontiers in Immunology, 2019
Many studies have demonstrated that immunobiotics with immunoregulatory functions improve the outcomes of several bacterial and viral infections by modulating the mucosal immune system.
Paulraj Kanmani, Hojun Kim
doaj   +1 more source