Results 31 to 40 of about 233,089 (385)

Shift happens: how to manage changing projects [PDF]

, 2016
This week, David Cameron was on a mission in Brussels to re-sell his controversial speech held in January. In his speech, the Prime Minister promised an “in-out” referendum on British EU membership after the next elections, as support for the EU was ...
Sting, F.J. (Fabian)
core   +10 more sources

Experimental Assays to Assess the Efficacy of Vinegar and Other Topical First-Aid Approaches on Cubozoan (Alatina alata) Tentacle Firing and Venom Toxicity

Toxins, 2016
Despite the medical urgency presented by cubozoan envenomations, ineffective and contradictory first-aid management recommendations persist. A critical barrier to progress has been the lack of readily available and reproducible envenomation assays that ...
Angel A. Yanagihara, Christie Wilcox, Rebecca King, Kikiana Hurwitz, Ann M. Castelfranco   +4 more
doaj   +1 more source

Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation

Journal for ImmunoTherapy of Cancer, 2023
Background and aims Macrophage innate immune response plays an important role in tumorigenesis. However, the role and mechanism of macrophage STING signaling in modulating tumor microenvironment to suppress tumor growth at secondary sites remains largely
Yu Sun, Haoran Hu, Zheng Liu, Jian Xu, Yiyun Gao, X. Zhan, Shun Zhou, Weizhe Zhong, Dongming Wu, Ping Wang, Z. Rao, L. Kong, Haoming Zhou   +12 more
semanticscholar   +1 more source

STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy

Science immunology, 2023
The tumor-associated vasculature imposes major structural and biochemical barriers to the infiltration of effector T cells and effective tumor control. Correlations between stimulator of interferon genes (STING) pathway activation and spontaneous T cell ...
Lihong Wang-Bishop, Blaise R. Kimmel, Verra M. Ngwa, M. Madden, Jessalyn J. Baljon, David C. Florian, Ann Hanna, L. Pastora, Taylor L. Sheehy, Alexander J. Kwiatkowski, Mohamed Wehbe, Xiaona Wen, Kyle W. Becker, Kyle M. Garland, Jacob A. Schulman, Daniel Shae, Deanna N. Edwards, Melissa M. Wolf, R. Delapp, P. Christov, Kathryn E. Beckermann, J. Balko, W. Rathmell, J. Rathmell, Jin Chen, John T. Wilson   +25 more
semanticscholar   +1 more source

Bioecology and chemical diversity of abdominal glands in the iranian samsum ant Pachycondyla sennaarensis (Formicidae: Ponerinae)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
The genus Pachycondyla is a large group of ants in the Ponerini tribe, known mostly from tropical and subtropical regions. Pachycondyla sennaarensis, the so-called Samsum ant in the Middle East, is distributed throughout the African tropics, Arabian ...
MR Nikbakhtzadeh, K Akbarzadeh, S Tirgari   +2 more
doaj   +1 more source

Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

Molecular Neurodegeneration, 2023
DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways.
Yige Huang, Bangyan Liu, Subhash C. Sinha, Sadaf Amin, Li Gan   +4 more
semanticscholar   +1 more source

Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients

OncoImmunology, 2019
Caspase 3 (CASP3) has a key role in the execution of apoptosis, and many cancer cells are believed to disable CASP3 as a mechanism of resistance to cytotoxic therapeutics.
Maria Esperanza Rodriguez-Ruiz, Aitziber Buqué, Michal Hensler, Jonathan Chen, Norma Bloy, Giulia Petroni, Ai Sato, Takahiro Yamazaki, Jitka Fucikova, Lorenzo Galluzzi   +9 more
doaj   +1 more source

A technique for reducing supersonic transient loads on internal wind tunnel balances [PDF]

Tehnika
Design of slender supersonic missiles requires a comprehensive experimental support in the form of wind tunnel data for a wide range of flight parameters (angle of attack and Mach number). However, in supersonic wind tunnel testing, the problem exists of
Vuković Đorđe S., Damljanović Dijana B.   +1 more
doaj   +1 more source

Cytoplasmic chromatin triggers inflammation in senescence and cancer [PDF]

, 2017
Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a ...
Adams, Peter D., Ahasan Al Tanim, K.M., Barber, Glen N., Berger, Shelley L., Capell, Brian C., Dou, Zhixun, Garcia, Benjamin A., Ghosh, Kanad, Jiang, Tianying, Kaestner, Klaus H., Kieckhaefer, Julia E., Lan, Yemin, Lin, Yanping, Millar, Sarah E., Sen, Payel, Seykora, John T., Shoshkes-Carmel, Michal, Simithy, Johayra, Vizioli, Maria Grazia, Wangensteen, Kirk J., Xu, Caiyue, Xu, Mingang, Zhou, Zhuo, Zhu, Jiajun   +23 more
core   +2 more sources

Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases

Zoological Research, 2023
The innate immune system protects the host from external pathogens and internal damage in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING), and downstream signaling ...
Jing Pan, Chenjie Fei, Yang Hu, Xiang-yu Wu, Li Nie, Jiong Chen   +5 more
semanticscholar   +1 more source