Results 31 to 40 of about 205,346 (308)

Mitochondrial control of innate immune signaling by irradiated cancer cells

OncoImmunology, 2020
Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of ...
Takahiro Yamazaki, Lorenzo Galluzzi
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients

OncoImmunology, 2019
Caspase 3 (CASP3) has a key role in the execution of apoptosis, and many cancer cells are believed to disable CASP3 as a mechanism of resistance to cytotoxic therapeutics.
Maria Esperanza Rodriguez-Ruiz, Aitziber Buqué, Michal Hensler, Jonathan Chen, Norma Bloy, Giulia Petroni, Ai Sato, Takahiro Yamazaki, Jitka Fucikova, Lorenzo Galluzzi   +9 more
doaj   +1 more source

A study on biochemical composition of the sting gland (poison gland) and the reservoir (poison sac) of the dwarf honey bee Apis florea F. workers [PDF]

, 2014
The glands associated with the sting apparatus of worker honey bee Apis florea produce Venom which is known to be composed of a wide spectrum of biomolecules ranging from biogenic amines to peptides and proteins.
Devi, Anita, Kumar, Neelima R.
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Das Potenzial des Performativen in Theater, Schule und Sprach(en)bildung

TIPA. Travaux interdisciplinaires sur la parole et le langage
Dieser Artikel analysiert das Potenzial des Performativen für Lern- und Bildungsprozesse, insbesondere in der Theaterpädagogik und Sprachenbildung. Performatives Handeln verbindet kognitive, affektive, leiblich-körperliche und soziale Lernaspekte und ...
Wolfgang Sting
doaj   +1 more source

A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling. [PDF]

, 2018
Detection of viral genomes by the innate immune system elicits an antiviral gene program mediated by type I interferons (IFNs). While viral RNA and DNA species induce IFN via separate pathways, the mechanisms by which these pathways are differentially ...
Aliyari, Saba Roghiyh, Chapon, Maxime, Cheng, Genhong, Dev, Anurupa, Dhingra, Anant, Gerami, Hoda, Ghaffari, Amir A, Parvatiyar, Kislay, Pindado, Jose, Zaver, Shivam A   +9 more
core  

STING Millennium: a web-based suite of programs for comprehensive and simultaneous analysis of protein structure and sequence. [PDF]

, 2019
Sting Millennium suite intrinsics. SMS organization. Sting Millennium Modes. Sting Millennium Modules. Millennium Features.
ALMEIDA, C. L. de, BAUDET, C., CAMPOS, T. F. e, COSTA, I. C., DOMINIQUINI, F., FALCAO, P. R. K., FERREIRA, L. L., FREITAS, E. M. de, GOMES, G. B., HIGA, R. H., HORITA, L. G., INOUE, M. K., LIMA, C. S., LUNA, F. M., MANCINI, A. L., MATTIUZ, A. R., MIURA, R. T., NESHICH, G., OGAWA, F. O., OLIVEIRA, A. G., PALANDRANI, J. F., PAPPAS JUNIOR, G., SANTOS, G. F. dos, SOUZA, D. F. de, SOUZA, S., TOGAWA, R. C., TORRES, W. V., YAMAGISHI, M. E. B., ÁLVARO, A.   +28 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source