Results 91 to 100 of about 1,690 (150)

Lactylation as a metabolic-epigenetic switch in cancer: dual roles in cell death resistance and therapeutic vulnerability

Cell Death and Disease
Protein lactylation emerges as a pivotal metabolic rheostat, translating microenvironmental lactate flux into stable programs that orchestrate cancer treatment resistance. This review synthesizes recent advances under the framework of “Lactylation Switch
Chengjiao Yang, Ruici Yang, Binbin Zheng, Hongxiao Jiang, Xianteng Wang, Weiren Huang   +5 more
doaj   +1 more source

Formulation and evaluation of stiripentol oral suspension

Introduction: The current research work was carried out to develop a stable and effective suspension of stiripentol for treating epilepsy. Method: FT-IR study was used to evaluate the compatibility between drug and excipient and the physical ...
Kandekar,Ujjwala, Chounde,Limbaji, Bitale,Dinesh, Gaikwad,Ajit   +3 more
core   +1 more source

Stiripentol induces ER stress and pyroptosis in pancreatic cancer cells under metabolic stress by dysregulating SFAs/UFAs homeostasis. [PDF]

Cell Oncol (Dordr)
Ding J, Pan J, Xue W, Ying S, Zuo S, Xia R, Li Y, Quan M.   +7 more
europepmc   +1 more source

Fenfluramine for seizures in Dravet syndrome and Lennox-Gastaut syndrome: Mechanisms, clinical evidence, safety, and practical integration. [PDF]

Epilepsy Behav Rep
Janszky J, Janszky J, Horváth R.
europepmc   +1 more source

Host-derived lactic acid disrupts IFN efficacy via antiviral inhibition and proinflammatory amplification. [PDF]

Nat Commun
Tian M, Chen S, Huang J, Tan Y, Wang X, Li M, Zhu J, Li M, Guo H, Li X, Chai Z, Shan L, Fu Y, Tang Y, Zhang Z, Li M, Huang C, Wang N, Du W, Sun L, Wu K, Tu Q, Lan K, Liu Z.   +23 more
europepmc   +1 more source

Lactate metabolism links reactive microglia, amyloid pathology, and Aβ dynamics. [PDF]

J Neuroinflammation
Ashley CC, Constantino NJ, Pettit-Mee RJ, Snipes JA, Saito K, Irmen RE, Zhang R, Neary EM, Lanning MJ, Karch CM, Johnson LA, Morganti JM, Macauley SL.   +12 more
europepmc   +1 more source

The antiseizure medication stiripentol inhibits mitochondrial complex I by blocking early-stage electron transfer. [PDF]

J Biol Chem
Bouchez CL, Molinié T, Duranthon G, Lillo S, Pellon C, El Mammeri N, Dartigues B, Pasdois P, Pinson B, Nikolski M, Devin A, Mourier A, Ullrich RT, Daubon T.   +13 more
europepmc   +1 more source

Stiripentol: Unpublished results from the first phase 2 clinical trial in Lennox-Gastaut syndrome conducted in the early 1990s. [PDF]

Epilepsia
Auvin S, Serraz B, Lespinasse J, Chancharme L.   +3 more
europepmc   +1 more source

Relaxation dynamics vs crystallization kinetics in the amorphous state: the case of Stiripentol

With the aim of finding a correlation between the crystallization kinetics and the molecular dynamics of a substance that would allow prediction of its crystallization time as a function of temperature for a given a relaxation time, we have studied ...
Tamarit Mur, José Luis, Macovez, Roberto, Barrio Casado, María del, Ruiz, Guadalupe N., Romanini, Michela, Pardo Soto, Luis Carlos   +5 more
core  

Ameliorating Seizures in Dravet Syndrome: A Review of Newly Approved and Investigational Drugs, RNA and Gene-Based Therapies. [PDF]

CNS Drugs
Balestrini S, Scheffer IE.
europepmc   +1 more source