Results 81 to 90 of about 1,690 (150)

CTO inhibits the in situ growth of glioblastoma in mice and regulates the metabolism and inflammatory phenotype of glioma-associated microglia [PDF]

Jichu yixue yu linchuang
Objective To investigate the effects and regulatory mechanisms of carboxyamidotriazole orotate (CTO) on the metabolism and inflammatory mediators of glioma-associated microglia (GAM). Methods Tumor volume was regularly monitored by in vivo imaging, and
LI Yunfan, ZOU Jiaming, WANG Yucheng, JU Rui, GUO Lei
doaj   +1 more source

Advancements in Dravet Syndrome Therapeutics: A Comprehensive Look at Present and Future Treatment Horizons: A Focused Review

Annals of Indian Academy of Neurology
Dravet syndrome (DS) is a developmental epileptic encephalopathy, characterized by fever-triggered focal or hemiclonic seizures at onset with various associated comorbidities like intellectual disability, gait abnormalities, and behavioral issues.
Aakash Mahesan, Gautam Kamila, Sheffali Gulati   +2 more
doaj   +1 more source

Inhibiting lactylation for efficient treatment of renal fibrosis through targeting nanomedicine of renal lactate accumulation in obstructed kidney

Journal of Nanobiotechnology
Chronic kidney disease (CKD) is a major global public health issue, with a prevalence that continues to rise. However, effective therapeutic approaches are still lacking. Tubulointerstitial fibrosis (TIF) is a key pathological process in CKD progression,
Pingshi Zhao, Xiaoxi Hu, Qi Liu, Yanan Wang, Jiawei Sun, Shulin Li, Dong Sun   +6 more
doaj   +1 more source

Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression

Nature Communications
Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of glioblastoma. By screening a cluster of metabolic small-molecule compounds, we show that inhibiting glioblastoma cell glycolysis impairs macrophage migration and ...
Fatima Khan, Yiyun Lin, Heba Ali, Lizhi Pang, Madeline Dunterman, Wen-Hao Hsu, Katie Frenis, R. Grant Rowe, Derek A. Wainwright, Kathleen McCortney, Leah K. Billingham, Jason Miska, Craig Horbinski, Maciej S. Lesniak, Peiwen Chen   +14 more
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NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance

Cell Discovery
Alternative polyadenylation (APA) is critical for shaping transcriptome diversity and modulating cancer therapeutic resistance. While lactate is a well-established metabolic signal in cancer progression, its role in APA regulation remains unclear.
Jinlong Lin, Yixin Yin, Jinghua Cao, Yiyang Zhang, Jiewei Chen, Rixin Chen, Bingxu Zou, Cijun Huang, Yongrui Lv, Shuidan Xu, Han Yang, Peng Lin, Dan Xie   +12 more
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Leki sieroce — wigabatryna, felbamat, stiripentol, rufinamid - w leczeniu zespołów padaczkowych u dzieci [PDF]

, 2012
Autorzy przedstawili najnowsze dane dotyczące zastosowania tak zwanych leków sierocych w lekoopornych zespołach padaczkowych w różnych przedziałach wiekowych.
Służewska-Niedźwiedź, Monika, Służewski, Wojciech   +1 more
core  

Design and synthesis of novel stiripentol analogues as potential anticonvulsants

, 2012
A series of stiripentol (SIP) analogues namely, 2-1(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(aryl/H)hydrazinecarboxamides 7a-h, (+/-)-(5RS)-N-(aryl/H)-(1,3-benzodioxol-5-yl)-3-tert-butyl-4,5-dihydro-1H-pyrazole-1-carboxamides (+/-)
Aboul-Enein, Mohamed N.,, El-Azzouny, Aida A.,, Attia, Mohamed I.,, El-Behairy, Mohammed F.,, Kamilia M. Amin, Aida A. El-Azzouny, Maklad, Yousreya A.,, Mohamed N. Aboul-Enein, Mohamed Abdel-Rehim, Amin, Kamilia M.,, Yousreya A. Maklad, Mohamed I. Attia, Mohammed F. El-Behairy, Abdel-Rehim, Mohamed,   +13 more
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BRIDGING THE GAP BETWEEN SEIZURE CONTROL AND QUALITY OF LIFE: STIRIPENTOL AND FENFLURAMINE IN DRAVET SYNDROME [PDF]

Dravet syndrome is a severe, early childhood epileptic encephalopathy, most often associated with a mutation in the SCN1a gene characterized by drug resistance and high neurological burden.
Patrycja Fiertek, Karolina Niewczas, Katarzyna Herjan, Katarzyna Kozon, Patryk Pustuła, Adrianna Brzozowska, Piotr Armański, Marcin Sawczuk, Aleksandra Gradek, Katarzyna Krupa   +9 more
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Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2‐Mediated MLH1 Intron Retention

Advanced Science
Temozolomide (TMZ) resistance remains the major obstacle in the treatment of glioblastoma (GBM). Lactylation is a novel post‐translational modification that is involved in various tumors.
Qu Yue, Zhao Wang, Yixiong Shen, Yufei Lan, Xiangyang Zhong, Xin Luo, Tao Yang, Manqing Zhang, Boming Zuo, Tianci Zeng, Jiankun Lu, Yuankai Wang, Boyang Liu, Hongbo Guo   +13 more
doaj   +1 more source

Estabilització del compost farmacèutic Stiripentol mitjançant excipients polimèrics

Gran part dels fàrmacs que en l’actualitat es poden trobar al mercat estan generats per dos grups de substàncies clarament diferenciades. El primer d’aquests components es el principi actiu i es l’encarregat de l’acció farmacològica del medicament.
Pascual Herencia, Guillem
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