Results 71 to 80 of about 1,690 (150)

Study of the metabolic stability profiles of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro human model [PDF]

, 2023
New-generation antiepileptic drugs as perampanel, rufinamide and stiripentol emerged as alternatives in chronic epilepsy polytherapy. Hence, their metabolic stability and potential involvement in relevant drug-drug interactions (DDI) are of great ...
Alves, Gilberto, Falcão, Amílcar, Rodrigues, Márcio, Meirinho, Sara, Fortuna, Ana   +4 more
core  

Efficacy and tolerability of add‐on stiripentol in real‐world clinical practice: An observational study in Dravet syndrome and non‐Dravet developmental and epileptic encephalopathies

Epilepsia Open
Objective To assess efficacy and tolerability of stiripentol (STP) as adjunctive treatment in Dravet syndrome and non‐Dravet refractory developmental and epileptic encephalopathies (DREEs).
Antonio Gil‐Nagel, Angel Aledo‐Serrano, Álvaro Beltrán‐Corbellini, Laura Martínez‐Vicente, Adolfo Jimenez‐Huete, Rafael Toledano‐Delgado, Irene Gacía‐Morales, Adrián Valls‐Carbó   +7 more
doaj   +1 more source

Holistic management of epilepsy in adults with intellectual development disorders

Epileptic Disorders, Volume 28, Issue 4, Page 981-1006, August 2026.
Abstract This seminar addresses the complexity of the management of epilepsy in adults with intellectual development disorders (IDD), advocating holistic and multidisciplinary care aligned with the learning objectives of the International League Against Epilepsy. Epilepsy is significantly more prevalent in people with IDD, presenting unique diagnostic,
Elena Fonseca, Antonella Riva, Samuel López‐Maza, Malin Zaddach, Marie‐Claire Porter, Ingo Borggraefe, Lance Watkins, Andreas Schulze‐Bonhage, Rohit Shankar, Pasquale Striano, Lina Nashef   +10 more
wiley   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, Volume 13, Issue 41, 22 July 2026.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Lipase Catalysed Kinetic Resolution of Stiripentol

, 2012
Kinetic resolution of rac-Stiripentol, catalysed by lipase A from Candida antarctica by esterification with vinyl butanoate was performed with an E-value of 24.
Aboul-Enein, Mohamed Nabil, Sundby, Eirik, Anthonsen, Thorleif, Abdel-Rehim, Mohamed, El-Behairy, Mohammed Farrag, Attia, Mohamed Ibrahim, El-Azzouny, Aida Abd El-Sattar, Amin, Kamilia M., Jacobsen, Elisabeth Egholm   +8 more
core  

In vitro inhibition by stiripentol of rat brain cytochrome P-450-mediated naphthalene hydroxylation.

, 1988
1. The formation of 1-naphthol from naphthalene was investigated in rat brain 105,000 g particulate fraction. The reaction showed NADPH dependency and was inhibited by carbon monoxide.
Jenner P, Testa B, Mesnil M
core   +1 more source

Ex vivo inhibition of rat brain cytochrome P-450 activity by stiripentol.

, 1988
Stiripentol is an anti-epileptic drug of novel structure with previously demonstrated strong in vitro inhibitory activity on rat cerebral cytochrome P-450 mediated naphthalene hydroxylation [6]. When administered to rats as a single i.p.
Jenner P, Testa B, Mesnil M
core   +1 more source

A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy

, 2020
Background In recent randomized, placebo-controlled, phase III trials, highly purified cannabidiol demonstrated efficacy with an acceptable safety profile in patients with Lennox-Gastaut syndrome or Dravet syndrome.
Morrison, Gilmour, Ben-Menachem, Elinor,, Gunning, Boudewijn, VanLandingham, Kevan, Cabrera, C. M. A., Ben-Menachem, Elinor, Critchley, David, Tayo, B., Crockett, Julie, Arenas Cabrera, Carmen María, Wray, Louise, Crockett, J., Wray, L., Tayo, Bola, Toledo, M., Critchley, D., Morrison, G., Toledo, Manuel, Gunning, B., VanLandingham, K.   +19 more
core   +1 more source

Glioma conditioned medium promotes glycolysis and phenotypic transformation in macrophages [PDF]

Jichu yixue yu linchuang
Objective To explore the effects and mechanisms involved in glioma conditioned medium for inducing glycolysis and oncogenic mediators in macrophages.
ZHANG Diya, LI Yunfan, GUO Hongjiang, QIU Jiaxing, WANG Yucheng, JU Rui, GUO Lei
doaj   +1 more source