Results 51 to 60 of about 1,690 (150)

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

How Has the Treatment of Polish Children with Dravet Syndrome Changed? Future Perspectives

Biomedicines
Background: This report focuses on the treatment histories of 21 patients diagnosed with Dravet syndrome (DRVT) under the care of the Mother and Child Institute in Warsaw.
Anita Zielińska, Urszula Skarżyńska, Paulina Górka-Skoczylas, Tomasz Mazurczak, Aleksandra Kuźniar-Pałka, Karolina Kanabus, Dorota Hoffman-Zacharska, Elżbieta Stawicka   +7 more
doaj   +1 more source

A real‐life pilot study of the clinical application of pharmacogenomics testing on saliva in epilepsy

Epilepsia Open, 2023
Response to antiseizure medications (ASMs) can be influenced by several gene polymorphisms, causing either lower efficacy or higher occurrence of adverse drug reactions (ADRs).
Antonella Riva, Roberta Roberti, Gianluca D'Onofrio, Maria Stella Vari, Elisabetta Amadori, Valentina De Giorgis, Caterina Cerminara, Nicola Specchio, Nicola Pietrafusa, Mario Tombini, Giovanni Assenza, Silvia Cappanera, Carla Marini, Paolo Rasmini, Pierangelo Veggiotti, Federico Zara, Emilio Russo, Pasquale Striano   +17 more
doaj   +1 more source

Optimizing polytherapy management for Dravet syndrome in the United States: A National Expert Consensus

Epilepsia Open, EarlyView.
ABSTRACT Objectives Dravet syndrome (DS) is a severe, drug‐resistant developmental and epileptic encephalopathy (DEE) that requires polytherapy for adequate seizure control. The need to combine multiple antiseizure medications (ASMs), together with variability in seizure types, safety considerations, and evolving patient needs, makes treatment ...
Elaine Wirrell, Joseph Sullivan
wiley   +1 more source

Additional Results from Two Randomized, Placebo-Controlled Trials of Stiripentol in Dravet Syndrome Highlight a Rapid Antiseizure Efficacy with Longer Seizure-Free Periods

Neurology and Therapy
Introduction The efficacy of stiripentol in Dravet syndrome children was evidenced in two randomized, double-blind, placebo-controlled, phase 3 studies, namely STICLO France (October 1996–August 1998) and STICLO Italy (April 1999–October 2000), but data ...
Renzo Guerrini, Laurent Chancharme, Benjamin Serraz, Catherine Chiron   +3 more
doaj   +1 more source

Response to anti‐seizure medications in children carrying novel or previously reported HCN1 gene variants

Epilepsia Open, EarlyView.
Abstract Objective Variants in the HCN1 gene cause a syndrome of childhood epilepsy and developmental disability with a broad phenotypic range. Many affected children manifest with early infantile epileptic encephalopathy (EIEE) and highly drug‐resistant epilepsy.
Marium N. Khan, Nicholas P. Poolos
wiley   +1 more source

Analysis of Stiripentol Enantiomers on Several Chiral Stationary Phases : A Comparative Study

, 2015
A comparative study was developed for the separation of stiripentol enantiomers on several chiral stationary phases which were CyclobondI 2000 , S,S Whelk O1 , R,R Whelk O1 , Chiralcel OB , Chiralcel OF , Chiralcel OB-H and Chiralpak AD-RH .
El‑Behairy, Mohammed F., El‑Azzouny, Aida A., Badawey, Amr M., Saleh, Ola A., Aboul‑Enein, Hassan Y.   +4 more
core   +1 more source

Stiripentol, Eslicarbazepinacetat & Co.

, 2010
ZusammenfassungIn den vergangenen sechs Jahren wurden in Deutschland sechs neue Antikonvulsiva zugelassen: Pregabalin, Rufinamid, Zonisamid, Lacosamid, Stiripentol und Eslicarbazepin-acetat.
A. Merkenschlager, M. K. Bernhard, M. Landgraf, S. Syrbe   +3 more
core   +1 more source

In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions

Pharmacology Research & Perspectives, 2022
Fenfluramine (FFA) has potent antiseizure activity in severe, pharmacoresistant childhood‐onset developmental and epileptic encephalopathies (e.g., Dravet syndrome).
Parthena Martin, Maciej Czerwiński, Pallavi B. Limaye, Seema Muranjan, Brian W. Ogilvie, Steven Smith, Brooks Boyd   +6 more
doaj   +1 more source

Acute effect of antiseizure drugs on background oscillations in Scn1aA1783V Dravet syndrome mouse model

Frontiers in Pharmacology, 2023
Dravet syndrome (Dravet) is a rare and severe form of developmental epileptic encephalopathy. Antiseizure medications (ASMs) for Dravet patients include valproic acid (VA) or clobazam (CLB), with or without stiripentol (STP), while sodium channel ...
Shir Quinn, Shir Quinn, Marina Brusel, Mor Ovadia, Mor Ovadia, Moran Rubinstein, Moran Rubinstein, Moran Rubinstein   +7 more
doaj   +1 more source