Results 41 to 50 of about 1,690 (150)

Estabilització del compost farmacèutic Stiripentol mitjançant excipients polimèrics [PDF]

, 2017
Gran part dels fàrmacs que en l’actualitat es poden trobar al mercat estan generats per dos grups de substàncies clarament diferenciades. El primer d’aquests components es el principi actiu i es l’encarregat de l’acció farmacològica del medicament.
Pascual Herencia, Guillem
core   +2 more sources

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Efficacy and safety of stiripentol in the prevention and cessation of status epilepticus: A systematic review

Epilepsia Open
Status epilepticus (SE) is a life‐threatening emergency with high morbidity and mortality. In people with epilepsy, the management of SE is focused on early medical treatment.
Nicola Specchio, Stéphane Auvin, Adam Strzelczyk, Francesco Brigo, Vicente Villanueva, Eugen Trinka   +5 more
doaj   +1 more source

Intranasal Microemulsion as an Innovative and Promising Alternative to the Oral Route in Improving Stiripentol Brain Targeting

Pharmaceutics, 2023
Stiripentol (STP) is a new-generation antiepileptic only available for oral administration. However, it is extremely unstable in acidic environments and undergoes gastrointestinal slow and incomplete dissolution.
Sara Meirinho, Márcio Rodrigues, Adriana O. Santos, Amílcar Falcão, Gilberto Alves   +4 more
doaj   +1 more source

Prolonged fenfluramine use in open‐label studies of Dravet or Lennox–Gastaut syndromes: Long‐term safety, tolerability, patient global functioning, and considerations for interpreting effectiveness

Epilepsia, EarlyView.
This graphical abstract provides an overview of the content from this open‐label extension study of fenfluramine use in patients with Dravet syndrome or Lennox‐Gastaut syndrome. Abstract Objective Long‐term safety and global functioning are reported in patients with Dravet syndrome (DS) or Lennox–Gastaut syndrome (LGS) treated with fenfluramine in an ...
Antonio Gil‐Nagel, Kelly G. Knupp, Boudewijn Gunning, Domenica Immacolata Battaglia, Elizabeth A. Thiele, Ingrid E. Scheffer, An‐Sofie Schoonjans, Rima Nabbout, Nathalie Villeneuve, Kerstin Alexandra Klotz, Nicola Specchio, Rocio Sanchez‐Carpintero, Marta Zolnowska, Anne‐Liv Schulz, Lily Perrin, Najla Dickson, Mélanie Langlois, Amélie Lothe, Joseph Sullivan   +18 more
wiley   +1 more source

Suivi thérapeutique pharmacologique du stiripentol

, 2012
Le stiripentol est un antiépileptique de troisième génération, commercialisé depuis 2007, sous le nom de Diacomit®. Il est indiqué, toujours en association, dans le traitement de l’épilepsie myoclonique sévère du nourrisson ou syndrome de ...
Olivier Tribut, Danièle Bentué-Ferrer, Marie-Clémence Verdier   +2 more
core   +1 more source

Fatal Status Epilepticus in Dravet Syndrome

Brain Sciences, 2020
Dravet Syndrome (DS) is burdened by high epilepsy-related premature mortality due to status epilepticus (SE). We surveyed centres within Europe through the Dravet Italia Onlus and EpiCARE network (European Reference Network for Rare and Complex ...
Paola De Liso, Virginia Pironi, Massimo Mastrangelo, Domenica Battaglia, Dana Craiu, Marina Trivisano, Nicola Specchio, Rima Nabbout, Federico Vigevano   +8 more
doaj   +1 more source

Acute effects of anti‐seizure medications on network level dynamics: A systematic comparison using multielectrode arrays

Epilepsia, EarlyView.
Abstract Objective A multi‐electrode array (MEA) is a powerful extracellular recording technique for long‐term monitoring of neuronal network activity. In recent years, MEA‐based assays have been applied increasingly to evaluate drug efficacy and neurotoxicity, including the assessment of anti‐seizure medications (ASMs). However, systematic comparisons
Griselda Marku, Lena Gschossmann, Kerstin Hallmann, Heinz Beck, Kunihiko Araki   +4 more
wiley   +1 more source

Stiripentol: A Review in Dravet Syndrome

, 2019
Acknowledgments During the peer review process, the manufacturer of stiripentol was also offered an opportunity to review this article. Changes resulting from comments received were made on the basis of scientific and editorial merit.
James E. Frampton (4995257)
core   +1 more source

Perampanel, Brivaracetam, Cenobamate, Stiripentol, and Ganaxolone in Lennox-Gastaut Syndrome: A Comprehensive Narrative Review. [PDF]

J Clin Med
Background: Lennox–Gastaut syndrome (LGS) is a severe childhood-onset developmental and epileptic encephalopathy characterized by treatment-resistant seizures and significant morbidity.
Samanta D.
europepmc   +2 more sources