Results 91 to 100 of about 9,882,534 (302)
In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma
Advanced Science, EarlyView.By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He +20 more
wiley +1 more source
Shaping human mortality patterns through intrinsic and extrinsic vitality processes
Demographic Research, 2013 BACKGROUND While historical declines in human mortality are clearly shaped by lifestyle and environmental improvements, modeling patterns is difficult because intrinsic and extrinsic processes shape mortality through complex stochastic interactions ...
Ting Li, James Anderson
doaj
Advanced Science, EarlyView.Chronic oral administration of specific probiotic strains triggers gut microbiota dysbiosis and systemic metabolic perturbations in mice. Multi‐omics profiling reveals subsequent hippocampal glial remodeling and neuroinflammation, which are linked to cognitive impairment.
Yibin Lin +15 more
wiley +1 more source
Modeling Mortality: Empirical Studies on the Effect of Mortality on Annuity Markets. [PDF]
Chapter 3 of the dissertation models the macro-longevity risk and introduces a stochastic model for human mortality rates. Chapter 4 analyzes the importance of mortality improvement and mortality risk (macro- and micro-longevity risk and parameter ...
Hari, N.
core
A Hybrid Transfer Learning Framework for Brain Tumor Diagnosis
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.A novel hybrid transfer learning approach for brain tumor classification achieves 99.47% accuracy using magnetic resonance imaging (MRI) images. By combining image preprocessing, ensemble deep learning, and explainable artificial intelligence (XAI) techniques like gradient‐weighted class activation mapping and SHapley Additive exPlanations (SHAP), the ...
Sadia Islam Tonni +11 more
wiley +1 more source
Non mean reverting affine processes for stochastic mortality. [PDF]
In this paper we use doubly stochastic processes (or Cox processes) in order to model the random evolution of mortality of an individual. These processes have been widely used in the credit risk literature in modelling default arrival, and in this ...
Elisa Luciano, Elena Vigna
core
Stochastic modeling mortality [PDF]
, 2014 This article presents the methodology of stochastic modeling mortality on the example of the models: Lee-Carter, Renshaw-Haberman and Plat. As a result of calcula-tions, estimated model parameters describing the level of mortality in the Polish popula ...
Jodź, Kamil
core
Accounting for animal health in efficiency analysis: An application to Swedish dairy farms
American Journal of Agricultural Economics, EarlyView.Abstract Poor animal health is a central concern in modern livestock production. Despite the necessity to incorporate animal health in efficiency analysis, the theoretical and empirical developments are limited on this subject. This article appropriately characterizes the axiomatic properties of animal health within a production framework.
Frederic Ang +3 more
wiley +1 more source
Prediction model development of late-onset preeclampsia using machine learning-based methods.
PLoS ONE, 2019 Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality. Due to the lack of effective preventive measures, its prediction is essential to its prompt management.
Jong Hyun Jhee +7 more
doaj +1 more source
Effect of stochasticity on coinfection dynamics of respiratory viruses
BMC Bioinformatics, 2019 Background Respiratory viral infections are a leading cause of mortality worldwide. As many as 40% of patients hospitalized with influenza-like illness are reported to be infected with more than one type of virus.
Lubna Pinky +2 more
doaj +1 more source