Results 71 to 80 of about 9,882,534 (302)

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Contribution of early detection and adjuvant treatments to breast cancer mortality reduction in Catalonia, Spain. [PDF]

PLoS ONE, 2012
BACKGROUND: Reductions in breast cancer (BC) mortality in Western countries have been attributed to the use of screening mammography and adjuvant treatments.
Ester Vilaprinyo, Teresa Puig, Montserrat Rue   +2 more
doaj   +1 more source

ESTIMATION OF SALMON ESCAPEMENT: MODELS WITH ENTRY, MORTALITY AND STOCHASTICITY

Natural Resource Modeling, 1997
Understanding the dynamics of Prince William Sound pink salmon requires knowledge of the size of the spawning population in a stream over time. Periodic aerial surveys provide observations on the number of spawners, but the lack of daily observations requires a model to fill in the gaps.
Quinn, Terrance J. II., Gates, Richard
openaire   +1 more source

ARCH-COMP20 Category Report: Stochastic Models

, 2020
This report presents the results of a friendly competition for formal verification and policy synthesis of stochastic models. It also introduces new benchmarks within this category, and recommends next steps for this category towards next year’s edition ...
Khaled Mahmoud, Shmarov Fedor, Lavaei Abolfazl, Zamani Majid, Zuliani P, Abate Alessandro, Schupp Stefan, Hartmanns Arnd, Remke Anne, Blom Henk, Wooding Ben, Cauchi Nathalie, Pilch Carina, Vinod Abraham, Delicaris Joanna, Soudjani Sadegh   +15 more
core   +1 more source

Transformer‐Based PET/CT Fusion Enables Preoperative Prediction and Prognostic Stratification of Spread Through Air Spaces in Lung Adenocarcinoma

Advanced Science, EarlyView.
An eight‐stream 2.5D Transformer integrates complementary PET metabolic and CT morphologic information to estimate spread‐through‐air‐spaces risk before surgery in lung adenocarcinoma. The model generalizes across independent centers, while its continuous risk score independently stratifies progression‐free survival, supporting further prospective ...
Xin‐Yu Zhu, Meng Meng, Zhen‐Zhen Wang, Deng‐Lu Lu, Ya‐Min Wei, Xu‐Chang Mi, Xing‐Yu Mu, Wei Fu   +7 more
wiley   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Epithelial SLC25A20 Deficiency Drives Immunosuppressive Neutrophil Remodeling via ARG1 Palmitoylation to Promote Colorectal Cancer

Advanced Science, EarlyView.
SLC25A20 deficiency in tumor cells compromises mitochondrial LCFA transport, which suppresses FAO and drives compensatory release of palmitic acid‐enriched lipids into the TME. These tumor‐derived palmitic acids are taken up by TANs, promoting ZDHHC18‐catalyzed ARG1 palmitoylation.
Yue Han, Tian‐Yuan Tan, Bin Zhang, Ye‐Bin Fu, Wen Chen, Min‐Hui Yang, Yi‐Qing Wang, Yan‐Qing Ding, Shuang Wang   +8 more
wiley   +1 more source

Threshold stochastic unit root models [PDF]

, 2002
This paper introduces a new class of stochastic unit root (STUR) processes, where the randomness of the autorregresive unit root is driven by a threshold variable.
Gonzalo, Jesús, Montesinos, Raquel
core   +1 more source

Predicting evolution in response to climate change: the example of sprouting probability in three dormancy-prone orchid species [PDF]

Royal Society Open Science, 2017
Although many ecological properties of species respond to climate change, their evolutionary responses are poorly understood. Here, we use data from long-term demographic studies to predict evolutionary responses of three herbaceous perennial orchid ...
Richard P. Shefferson, Ryo Mizuta, Michael J. Hutchings   +2 more
doaj   +1 more source

Proposition of a hybrid stochastic Lee-Carter mortality model

Advances in Methodology and Statistics, 2013
In the paper, a stochastic hybrid mortality model (EHLC) treated as a solution of stochastic differential equations is introduced. The model is defined analogously to the well-known Lee-Carter mortality model (LC). A parameter estimation procedure including a switching rule are proposed. A comparison of the predictive accuracy of the LC and EHLC models
Rossa, Agnieszka, Socha, Lesław
openaire   +4 more sources