Results 81 to 90 of about 9,882,534 (302)
Advanced Science, EarlyView.PIVOT uses pathology‐derived morphologic and vascular representations from postoperative H&E and CD34 whole‐slide images to guide model development, while clinical inference requires only preoperative multiparametric MRI. Across five centers, PIVOT enabled accurate preoperative assessment of vessels encapsulating tumor clusters, stratified patients by ...
Zhehan Shen +12 more
wiley +1 more source
On the stochastic approach to marine population dynamics
Scientia Marina, 2007 The purpose of this article is to deepen and structure the statistical basis of marine population dynamics. The starting point is the correspondence between the concepts of mortality, survival and lifetime distribution.
Eduardo Ferrandis
doaj +1 more source
An Estimable Dynamic Stochastic Model of Fertility and Child Mortality [PDF]
Journal of Political Economy, 1984 This paper develops a finite-horizon dynamic stochastic model of discrete choice with respect to life-cycle fertility within an environment where infant survival is uncertain. The model yields implications for the number, timing, and spacing of children. A tractable estimation method is developed for the linear constraint-quadratic utility case that is
openaire +2 more sources
Stochastic population forecasts using functional data models for mortality, fertility and migration [PDF]
Age-sex-specific population forecasts are derived through stochastic population renewal using forecasts of mortality, fertility and net migration. Functional data models with time series coefficients are used to model age-specific mortality and fertility
Heather Booth, Rob J Hyndman
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Advanced Science, EarlyView.By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo +15 more
wiley +1 more source
Non mean reverting affne processes for stochastic mortality [PDF]
In this paper we use doubly stochastic processes (or Cox processes) in order to model the random evolution of mortality of an individual. These processes have been widely used in the credit risk literature in modelling default arrival, and in this ...
Elisa Luciano, Elena Vigna
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Advanced Science, EarlyView.Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song +8 more
wiley +1 more source
Advanced Science, EarlyView.Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler +4 more
wiley +1 more source
Catastrophe risk in a stochastic multi‐population mortality model
Journal of Risk and InsuranceAbstractThis paper incorporates mortality shocks in the scenarios for future mortality rates produced by a stochastic multi‐population mortality model. Hereto, the proposed model combines a decreasing stochastic mortality trend with a mechanism that switches between regimes of low and high volatility.
Robben, Jens, Antonio, Katrien
openaire +3 more sources
Stochastic Mortality, Macroeconomic Risks, and Life Insurer Solvency [PDF]
Motivated by a recent demographic study establishing a link between macroeconomic fluctuations and the mortality index kt in the Lee-Carter model, we assess the impact of macroeconomic fluctuations on the solvency of a life insurance company. Liabilities
Helmut Gründl +2 more
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