Results 121 to 130 of about 2,263,488 (304)

Revealing the Mechanism of Protein Degradation in Postmortem Meat: The Role of Phosphorylation and Ubiquitination

open access: yesFoods
The aim of this study was to investigate the possible effects of phosphorylation and ubiquitination on the degradation of myofibrillar proteins in mutton with different tenderness.
Xinran Zhao   +7 more
doaj   +1 more source

Drinking Water Quality Deterioration in Households of Students with High Illness Absenteeism [PDF]

open access: yes, 2011
Objective: School and household lacked safe drinking water and thus school absenteeism rates were high among students with poor water quality. So we assessed fecal contamination of drinking water in households of students with high illness absenteeism ...
Bhadange, DG, Shirsat, SD, Tambekar, DH
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

DIA-based quantitative proteomic analysis on porcine meat quality at different chilling rates

open access: yesFood Science and Human Wellness
The objective of this study was to evaluate the effects of chilling rate on porcine meat quality from the perspective of proteome using data independent acquisition (DIA)-based quantitative proteomic strategy. M.
Yuqiang Bai   +7 more
doaj   +1 more source

Comparing instance-averaging with instance-saving learning algorithms [PDF]

open access: yes, 1988
The goal of our research is to understand the power and appropriateness of instance-based representations and their associated acquisition methods. This paper concerns two methods for reducing storage requirements for instance-based learning algorithms ...
Aha, David W., Kibler, Dennis
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Effects of Pyruvate Kinase Phosphorylation and Acetylation on Its Activity and Structure

open access: yesShipin gongye ke-ji
Pyruvate kinase is one of the important glycolytic enzymes that affects the rate of postmortem muscle glycolysis and then regulates meat quality.
Xiaolan HUANG   +7 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Structural Characterization, Constipation-Relieving, and Hypolipidemic Activity of Polysaccharides from Fresh and Processed Dendrobium officinale

open access: yesFoods
Dendrobium officinale (DO) is a traditional medicinal and edible plant whose polysaccharides help modulate gastrointestinal and metabolic functions. Fresh DO is commonly processed into “Fengdou” to prolong shelf life, but the effects of this processing ...
Tingting Ding   +10 more
doaj   +1 more source

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