Results 151 to 160 of about 11,489 (305)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Trends in the Range of Zero Alcohol Products Available in Supermarkets and Alcohol Stores in Australia. [PDF]

Drug Alcohol Rev
Pettigrew S, Davies T, Sträuli B, Yusoff A, O'Brien P, Jongenelis M, Brownbill A, Jones A, Taylor F, Bowen J.   +9 more
europepmc   +1 more source

Positioning of store brands

, 1998
In this dissertation, we examine the retailer\u27s store brand positioning problem using a game theoretic approach. Specifically, we consider a product market consisting of two national brands that may differ in strength.
Sayman, Serdar
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Association Between Product Attributes and Oral Nicotine Pouch Preference-Evidence From Online Stores. [PDF]

Nicotine Tob Res
Hardin A, Ahn S, Ma S, Thai V, Berman M, Mays D, Chen J, Paskett ED, Wagener TL, Shang C.   +9 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

The Impact of US Food and Drug Administration's Advisory and Enforcement Actions on US Sales of Esco Bars Products in 2023: Synthetic Control Approach. [PDF]

JMIR Public Health Surveill
Shin H, Hannings J, Cahn Z, Xu X, Toblin R, Farrelly M, King BA.   +6 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Pushing the US nicotine pouch market: insights from Zyn's free can campaign in September 2025. [PDF]

Tob Control
Talbot EM, Ganz O, Jensen JK, Mays D, Rose SW, Ackerman C, Hrywna M, Lee JGL, Bover Manderski MT, Barnwell PV, Mercincavage M, Henriksen L, Delnevo CD.   +12 more
europepmc   +1 more source

Estimating the Value of Retail Beef Product Brands and Other Attributes

This paper finds wide variation in brand premiums and discounts across types of branded beef cuts, ranging from -98 cents for a brand of ground beef targeting cost-conscious consumers to $4.15 for a brand of steak produced by a family-operated beef ...
Martinez, Stephen W.
core   +1 more source