Results 201 to 210 of about 7,158 (262)

Removing Tobacco Price Discounts from the Retail Point-of-Sale Exterior Reduces Young Adults' Future Cigarette Smoking Susceptibility: an Experimental Investigation. [PDF]

Addict Behav
Dunbar MS, Setodji CM, Martino SC, Wong JCS, van Valkenburg G, Jenson D, Shadel WG.   +6 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Evaluation of Golf Apparel for Ultraviolet Protection: An Analysis of Skin Coverage Provided by Leading U.S. Golf Apparel Brands for a High-Risk Population. [PDF]

Cureus
Merkle T, Lama J, Yang H, Patel M, Ilyas E.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Appeal and Sensory Characteristics of Oral Nicotine Products in Young Adults Who Vape E-Cigarettes. [PDF]

Nicotine Tob Res
Peraza N, Han DH, Whaley RC, Vogel EA, Monterosso JR, Gonzalez Anaya MJ, Patel DJ, Jafarzadeh NS, Hong K, Mason TB, Tackett AP, Leventhal AM.   +11 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Pasteurized Milk Serves as a Passive Surveillance Tool for Highly Pathogenic Avian Influenza Virus in Dairy Cattle. [PDF]

Viruses
Gontu A, Sekhwal MK, Diaz Huemme A, Li L, Kutsaya S, Ling M, Doshi NK, Byukusenge M, Nissly RH.   +8 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preliminary determination of <i>a priori</i> information for forensic lubricant analysis in sexual assault cases. [PDF]

Forensic Sci Res
Bridge C, Baumgarten B, Tang L, Nguyen NT.   +3 more
europepmc   +1 more source

Assessing nutritional composition and ingredients of packaged foods in Brazil: an in-store census method for creating a comprehensive food label database. [PDF]

Front Nutr
Kraemer MVDS, Fernandes AC, Chaddad MCC, Scapin T, de Barros BV, Milano E, Padovan M, Uggioni PL, Bernardo GL, Khandpur N, Ares G, Proença RPDC.   +11 more
europepmc   +1 more source