Results 11 to 20 of about 44,419 (247)
Single-molecule force spectroscopy of toehold-mediated strand displacement [PDF]
Nature CommunicationsToehold-mediated strand displacement (TMSD) is extensively utilized in dynamic DNA nanotechnology and for a wide range of DNA or RNA-based reaction circuits.
Andreas Walbrun +5 more
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DNA Strand-Displacement Temporal Logic Circuits. [PDF]
J Am Chem Soc, 2022 Molecular circuits capable of processing temporal information are essential for complex decision making in response to both the presence and history of a molecular environment. A particular type of temporal information that has been recognized to be important is the relative timing of signals.
Lapteva AP, Sarraf N, Qian L.
europepmc +4 more sources
Non-enzymatic primer extension with strand displacement
eLife, 2019 Non-enzymatic RNA self-replication is integral to the emergence of the ‘RNA World’. Despite considerable progress in non-enzymatic template copying, demonstrating a full replication cycle remains challenging due to the difficulty of separating the ...
Lijun Zhou +6 more
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Kinetics of RNA and RNA:DNA Hybrid Strand Displacement
ACS Synthetic Biology, 2021 In nucleic acid nanotechnology, strand displacement is a widely used mechanism where one strand from a hybridized duplex is exchanged with an invading strand that binds to a toehold, a single-stranded region on the duplex. It is used to perform logic operations on a molecular level, initiate cascaded reactions, or even for in vivo diagnostics and ...
Hao Yan, Thomas Ouldridge, Junyi Che
exaly +4 more sources
Small-Molecule Analysis Based on DNA Strand Displacement Using a Bacteriorhodopsin Photoelectric Transducer: Taking ATP as an Example [PDF]
Sensors, 2023 A uniformly oriented purple membrane (PM) monolayer containing photoactive bacteriorhodopsin has recently been applied as a sensitive photoelectric transducer to assay color proteins and microbes quantitatively.
Hsiu-Mei Chen +2 more
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Cotranscriptionally encoded RNA strand displacement circuits. [PDF]
Sci Adv, 2022 Engineered molecular circuits that process information in biological systems could address emerging human health and biomanufacturing needs. However, such circuits can be difficult to rationally design and scale. DNA-based strand displacement reactions have demonstrated the largest and most computationally powerful molecular circuits to date but are ...
Schaffter SW, Strychalski EA.
europepmc +3 more sources
Logical Reasoning Based on DNA Strand Displacement [PDF]
Jisuanji kexue, 2022 A computational model for logical reasoning is proposed based on DNA strand displacement reactions.Firstly,this way does not rely on fluorescent labeling or other DNA experimental technique.The corresponding relationship between the concentration change ...
WU Li-bo, HUANG Yu-fang
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Dissipative Control over the Toehold-Mediated DNA Strand Displacement Reaction. [PDF]
Angew Chem Int Ed Engl, 2022 Del Grosso E +5 more
europepmc +2 more sources
Biomolecules, 2022 DNA and RNA strand exchange is a process of fundamental importance in biology. Herein, we used a FRET-based assay to investigate, for the first time, the stand exchange kinetics of natural DNA, natural RNA, and locked nucleic acid (LNA)-modified DNA ...
Ivana Domljanovic +4 more
doaj +1 more source
Sequencing double-stranded DNA by strand displacement [PDF]
Nucleic Acids Research, 1997 Duplex probes with five base single-stranded overhangs can capture dsDNA targets from type IIS restriction nuclease digests. Ligation generates a predesigned nick site, where DNA polymerase can generate sequencing ladders by strand displacement or nick translation in the presence of trace amounts of dideoxynucleotides.
D J, Fu +3 more
openaire +2 more sources