Results 31 to 40 of about 812,407 (248)

Four-Input Multi-Layer Majority Logic Circuit Based on DNA Strand Displacement Computing

open access: yesIEEE Access, 2020
Biomolecules have the advantage of high performance parallel computing and large information capacity. The use of biochemical circuits to solve computational problems has been studied by many researchers.
Yanfeng Wang, Guodong Yuan, Junwei Sun
doaj   +1 more source

Modelling toehold-mediated RNA strand displacement [PDF]

open access: yes, 2015
We study the thermodynamics and kinetics of an RNA toehold-mediated strand displacement reaction with a recently developed coarse-grained model of RNA. Strand displacement, during which a single strand displaces a different strand previously bound to a ...
Doye, Jonathan P. K.   +9 more
core   +1 more source

Study of E. coli Hfq's RNA annealing acceleration and duplex destabilization activities using substrates with different GC-contents [PDF]

open access: yes, 2012
Folding of RNA molecules into their functional three-dimensional structures is often supported by RNA chaperones, some of which can catalyse the two elementary reactions helix disruption and helix formation.
Saxena, Krishna   +6 more
core   +1 more source

Modelling DNA-strand displacement reactions in the presence of base-pair mismatches [PDF]

open access: yes, 2020
Toehold-mediated strand displacement is the most abundantly used method to achieve dynamic switching in DNA-based nanotechnology. An ‘invader’ strand binds to the ‘toehold’ overhang of a target strand and replaces a target-bound ’incumbent’ strand ...
Seidel, Ralf   +5 more
core   +1 more source

Non-enzymatic primer extension with strand displacement

open access: yeseLife, 2019
Non-enzymatic RNA self-replication is integral to the emergence of the ‘RNA World’. Despite considerable progress in non-enzymatic template copying, demonstrating a full replication cycle remains challenging due to the difficulty of separating the ...
Lijun Zhou   +6 more
doaj   +1 more source

Characterization and engineering of a DNA polymerase reveals a single amino-acid substitution in the fingers subdomain to increase strand-displacement activity of A-family prokaryotic DNA polymerases

open access: yesBMC Molecular and Cell Biology, 2019
Background The discovery of thermostable DNA polymerases such as Taq DNA polymerase revolutionized amplification of DNA by polymerase chain reaction methods that rely on thermal cycling for strand separation.
Yvonne Piotrowski   +2 more
doaj   +1 more source

Highly sensitive electrochemical assay based on strand displacement polymerization-assisted CRISPR/Cas12a collateral cleavage

open access: yesElectrochemistry Communications, 2023
In this work, a novel strand displacement polymerization strategy is designed with a single hairpin-structured DNA probe acting as both of primer and template.
Yulin Zhu   +5 more
doaj   +1 more source

Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism [PDF]

open access: yes, 2005
The established strand-displacement model for mammalian mitochondrial DNA (mtDNA) replication has recently been questioned in light of new data using two-dimensional (2D) agarose gel electrophoresis.
Tkachuk, An   +4 more
core   +1 more source

Coupling RNA annealing and strand displacement: a FRET-based microplate reader assay for RNA chaperone activity

open access: yesBioTechniques, 2007
Proteins with RNA chaperone activity help RNAs to obtain their native conformations, and many of them are active in the two basic reactions—RNA annealing and strand displacement.
Lukas Rajkowitsch, Renée Schroeder
doaj   +1 more source

DNA Logic Multiplexing Using Toehold-Mediated Strand Displacement

open access: yesIEEE Access, 2020
Since the discovery of the DNA Strand Displacement mechanism, researchers have implemented a lot of applications, such as DNA computing, DNA Circuits, Logic gates, and Chemical Reaction network.
Congzhou Chen   +4 more
doaj   +1 more source

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