The Fibrous Proteins Of Stratum Corneum [PDF]
Journal of Investigative Dermatology, 1976 The proteins of cow snout stratum corneum can be extracted in part with Tris buffer, pH 9.0, containing 6 M urea. Sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis shows that about half the extracted material migrates as prekeratin when the extract is treated with both SDS and mercaptoethanol; only trace amounts of the proteins migrating ...
Baden, H.P., Lee, L.D., Kubilus, J.
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Measurement of drug diffusivity in stratum corneum membranes and a polyacrylate matrix [PDF]
, 1991 Diffusivities have been determined for the drug clenbuterol for three non-sink, diffusional problems: diffusion out of a polymer matrix, diffusion through excised, human stratum corneum, and the combined case of diffusion out of a polymer matrix through ...
Lee, Geoffrey, Göpferich, Achim
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The pH of the skin surface and its impact on the barrier function [PDF]
, 2006 The `acid mantle' of the stratum corneum seems to be important for both permeability barrier formation and cutaneous antimicrobial defense. However, the origin of the acidic pH, measurable on the skin surface, remains conjectural.
Korting, Hans Christian +1 more
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Investigating the Nanostructure of the Stratum Corneum Lipid Matrix: A Combined Neutron Diffraction & Molecular Dynamics Simulations Approach [PDF]
, 2022 The human skin provides a physiochemical and biological protective barrier to the body due to the unique structure of its outermost layer the stratum corneum. This layer consists of corneocytes and a multi-lamellar lipid matrix forming a composite, which
Rakesh, Gupta +4 more
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Effect of continuous phase drug concentration, evaporation and partitioning on transdermal drug permeation kinetics with lipophilic vehicles [PDF]
, 2008 In this work the dependence of transdermal drug permeation kinetics on continuous phase drug concentration, partitioning between formulation phases, partitioning between stratum corneum and continuous oil phase and evaporation of volatile formulation ...
Reiser, Miriam Regina Luise
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Evaluation of topical bioavailability in human stratum corneum in vivo by tape stripping using a direct sprectroscopic method [PDF]
, 2006 The objective of this thesis was to develop a spectrophotometric methodology for simultaneous determination of a sunscreening agent and relative stratum corneum tissue density in skin tape strips.
Fässler Tassopoulos, Tatiana
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Development of an optimised application protocol for sonophoretic transdermal delivery of a model hydrophilic drug [PDF]
, 2011 It has now been known for over a decade that low frequency ultrasound can be used to effectively enhance transdermal drug penetration - an approach termed sonophoresis.
Abdul, Rasool +3 more
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Electrochemical microsensors for cutaneous surface analysis: Application to the determination of pH and the antioxidant properties of stratum corneum [PDF]
, 2008 Potentiometry and cyclic voltammetry were proposed as simple, reliable and non invasive methods for the simultaneous determination of pH and antioxidant properties of skin.
Ruffien-Ciszak, A +9 more
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SerpinB2 deficiency results in a stratum corneum defect and increased sensitivity to topically applied inflammatory agents [PDF]
, 2016 SerpinB2 (plasminogen activator inhibitor type 2) is constitutively expressed at high levels by differentiating keratinocytes in mice and humans; however, the physiological function of keratinocyte SerpinB2 remains unclear.
Nakaya, Helder I. +23 more
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Topical bioavailability of glucocorticosteroids : dermatopharmacokinetic and dermatopharmacodynamic of topically applied triamcinolone acetonide in humans [PDF]
, 2006 The aim of the present thesis was the in vivo investigation of the topical bioavailability of a model glucocorticosteroid, triamcinolone acetonide (TACA), using tape stripping. The layer by layer removal of the stratum corneum by tape stripping enables
Pellanda, Carolina
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