Results 251 to 260 of about 323,420 (331)

Asymmetric δ-Lactam Synthesis with a Monomeric Streptavidin Artificial Metalloenzyme

, 2019
Isra S. Hassan, Angeline N. Ta, Michael W. Danneman, Natthawat Semakul, Matthew Burns, Corey H. Basch, Vanessa N. Dippon, Brian R. McNaughton, Tomislav Rovis   +8 more
openalex   +2 more sources

Targeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization

Advanced Science, EarlyView.
This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao   +11 more
wiley   +1 more source

An engineered redox-switchable streptavidin mutein enables the high-affinity capture and efficient elution of biotinylated ligands. [PDF]

Protein Sci
Marangoni JM, Zutic A, Dhindsa A, Uche-Orji E, Wong SL, Ng KKS.   +5 more
europepmc   +1 more source

Forsythoside E Alleviates Liver Injury by Targeting PKM2 Tetramerization to Promote Macrophage M2 Polarization

Advanced Science, EarlyView.
Here, the study shows for the first time that Forsythoside E (FE) can promote PKM2 tetramerization by binding to its K311 site. Furthermore, it induces metabolic reprogramming of macrophages and inhibits NLRP3 expression. Finally, it can alleviate sepsis‐induced liver injury by promoting M2 anti‐inflammatory polarization.
Bingxin Wu, Xuechun Yu, Yanling Li, Lin An, Rongrong Zhang, Rong Zhang, Fan Zhang, Zhongqiu Liu, Caiyan Wang   +8 more
wiley   +1 more source

Generation of high-quality single-stranded DNA for full-length and truncated genome standards of recombinant adeno-associated viruses. [PDF]

Mol Ther Methods Clin Dev
Manz J, Ruppert R, Haindl M, Hubbuch J, Graf T, Pschirer J.   +5 more
europepmc   +1 more source

Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers

Advanced Science, EarlyView.
A multivalent aptamer corona is evolved via established ProteoFish‐SELEX (systematic evolution of ligands by exponential enrichment) for high‐throughput multiplexed detection of multiple cancers. Clinical validation using multivalent aptamer corona demonstrated high accuracy and specificity in multiplexed detection of ovarian, lung, and colorectal ...
Mengjie Wang, Baichuan Jin, Xin Dai, Haozhe Huang, Qiqi Liu, Jianqing Zhu, Haixing Ju, Qixun Chen, Yongmei Song, Weihong Tan, Yuan Liu   +10 more
wiley   +1 more source

Integrating endogenous TurboID and data-independent acquisition mass spectrometry for in vivo proximity labeling. [PDF]

EMBO J
Fay DS, Balasubramaniam B, Harrington SM, Edeen PT.   +3 more
europepmc   +1 more source

Optofluidic twin-core hollow fiber interferometer for label-free sensing of the streptavidin-biotin binding

, 2018
Xinghua Yang, Wenting Yu, Zhihai Liu, Jun Yang, Yu Zhang, Depeng Kong, Qunlong Long, Tingting Yuan, Jiaming Cao, Libo Yuan, Kyunghwan Oh   +10 more
openalex   +2 more sources

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

Inverted H1 hemagglutinin nanoparticle vaccines protect mice against challenges with human H1N1 and bovine H5N1 influenza viruses. [PDF]

NPJ Vaccines
Biswas A, Loeffler K, Kim D, Eisfeld AJ, Duffy A, Hammond H, Sangappa A, Abozeid HH, Neumann G, Moreno A, Kawaoka Y, Kane RS.   +11 more
europepmc   +1 more source