Results 131 to 140 of about 137,892 (306)

When to consider an inborn error of immunity: clues for physicians

Internal Medicine Journal, EarlyView.
Abstract The term inborn errors of immunity (IEIs) refers to the rapidly expanding group of genetic disorders causing dysregulation of the immune system. With improved genetic testing in recent years, the number of defined IEIs and their range of phenotypic presentations has grown vastly, with more than 550 IEIs now described.
Meera Thangarajah, Lucinda J. Berglund
wiley   +1 more source

Exploitation of Host Signal Transduction Pathways Induced by Streptococcus pneumoniae

, 2015
The induction of host signal transduction cascades by bacterial pathogens contributes directly to their virulence. In addition to the pore-forming cytolysin pneumolysin, several surface-exposed proteins of Streptococcus pneumoniae are also potent ...
Bergmann, Simone,, Hammerschmidt, Sven,, Lund University., Agarwal, Vaibhav,   +3 more
core   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Catheter‐Associated Urinary Tract Infections in Children: An Evidence‐Informed Narrative Review of Diagnosis, Management and Prevention

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Catheter‐associated urinary tract infections (CAUTI) are a common healthcare‐associated infection in children and a major contributor to increased morbidity, prolonged hospital stays and higher healthcare costs. This narrative review uses an evidence‐informed approach highlighting recent paediatric literature (2000–2025) to provide an overview
Simon P. Paget, Robert McCusker, Suzanne Simpson, Melissa Short, Angela Berkhout   +4 more
wiley   +1 more source

Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis

, 2011
Streptococcus suis is one of the most important pathogens in pigs and is also an emerging zoonotic agent. After crossing the epithelial barrier, S. suis causes bacteraemia, resulting in meningitis, endocarditis and bronchopneumonia.
Smith, H.E., Smith, H E, H. E. Smith, R. Goethe, Rohde, Manfred, Valentin-Weigand, P., M. Rohde, Goethe, R, J. Willenborg, Willenborg, J, de Greeff, A, Goethe, R., Willenborg, J., A. de Greeff, Valentin-Weigand, P, De Greeff, A., Greeff, A., De, P. Valentin-Weigand, Fulde, M., M. Fulde, Fulde, M, Rohde, M.   +21 more
core   +1 more source

Will Extended‐Valency Pneumococcal Conjugate Vaccines Offer Enhanced Coverage Against Invasive Pneumococcal Disease for At‐Risk Children?

Acta Paediatrica, EarlyView.
Robert Cohen, Corinne Levy, Naim Ouldali, Stéphane Béchet, Aude Estivaux, André Birgy, Isabelle Hau, IPD Study Group, Emmanuelle Varon   +8 more
wiley   +1 more source

Assessing the Reduction of Recurrent Admissions Using OM‐85 for the Treatment of Preschool Wheeze (ARROW): Protocol for a Multi‐Centre, Randomised, Double‐Blind, Placebo‐Controlled Trial

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aims Acute wheezing illnesses are among the most common reasons preschool‐aged children are admitted to hospital. Readmission rates are high, and novel preventive strategies are required. OM‐85 is an orally administered bacterial lysate that stimulates anti‐viral immune responses and reduces excessive airway inflammation associated with ...
Jessica C. Costa‐Pinto, Marisa van Arragon, Katherine J. Lee, Lisa Gold, Peter D. Sly, Cameron C. Grant, Sarah McNab, Peter Vuillermin, Children's Inpatient Research Collaboration of Australia and New Zealand (CIRCAN) Investigator Group, Rebecca Alekzander, Ravichandra Balakrishnamoorthy, Sean Beggs, Habib Bhurawala, Stewart Birt, Katie Bongiolatti, Stephen Brancatisano, Blessy Charles, Roni Cole, Jessica C. Costa‐Pinto, Bailey Craig, Jacqueline Dalby‐Payne, Taya Dowling, Chris Elliot, Daniel Engleman, Wei Qi Fan, Alice Fang, Jane Fata, Catriona Fleming, Jacqueline Fradley, Jeremy Furyk, Arun Gangakhedkar, Lisa Gold, Angus Goodson, Peter Gowdie, Cameron Grant, Kelly Grant, Shehani Gunasekera, Louise Guy, Danielle Hanlon, Rachael Healey, Reena Ho, Sharon Jones, Datta Joshi, Vishal Kapoor, Jonathan Kaufman, Elizabeth Kepreotes, Annie Kilpatrick, Helena Kim, Kristy Kimlin, Christine Kwa, Julia Laing, Anita Lala, Malia Lardelli, Christine Lau, Shirley Lawrence, Katherine J. Lee, Rachel Lee, Jordan Levinter, David Levitt, Hannah Lorking, Lorraine Torrance, April Ly, Ariel Mace, Maricar Santiago Maminta, Payal Mandaliya, Natalie Martin, Brendan McCann, Timothy McDonald, Richard G. McGee, Kathryn McMahon, Sarah McNab, Kristen Mead, Tania Milne, Vasemaca Moi, Nerida Moore, Dylan Mordaunt, Tanya Newnham, Mark Norden, Kirra Philip, Maree Pigdon, Melanie Pillay, Michael Plaister, Jolene Reid, Julia Reid, Nicholas Reid, Kathryn Roberts, Maria Ronan, Thomas Saunders, Jennifer Schaefer, Rachel Schembri, Leonie Shah, Owen Sinclair, Peter Sly, Gail Spence, Jane Standish, Alicia Stanley, Simon Stokes, Scott Sypek, Laurel Teoh, Rachel Teulon, Clare Thomas, David Tickell, Laarni Tundag, Marisa Van Arragon, Peter Vuillermin, Ushma Waida, Matthew Wakeley, Alexandra Wallace, Todd Wallace, Simone Watkins, Ben Watson, Cilla Wyllie‐Schmidt, Rose Ann Yap, Helen Young, Joel Ziffer   +114 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

The Oral‐Gut Axis: Bidirectional Interactions Between Microbiome and Diseases

Journal of Periodontal Research, EarlyView.
This study aims to summarize the mechanisms underlying ectopic colonization of the gut by oral pathobionts and the microbial and host factors that regulate this process. ABSTRACT Increased colonization of typically oral microorganisms is frequently observed in the gut mucosa or lumen of individuals with gastrointestinal disorders, including patients ...
Shinya Ebihara, Nobuhiko Kamada
wiley   +1 more source

Lack of association between vaccine‐induced immune thrombocytopenia and thrombosis and HLA loci in a large cohort

British Journal of Haematology, EarlyView.
Linda Schönborn, Ana Tzvetkova, Thomas Thiele, Uwe Völker, Sabine Ameling, Sören Franzenburg, Lars Kaderali, Andreas Greinacher   +7 more
wiley   +1 more source