Results 151 to 160 of about 181,208 (343)

In Vitro Astroglial Dysfunction Induced by Neurotoxins: Mimicking Astrocytic Metabolic Alterations of Alzheimer’s Disease

Metabolites
Astrocytes play fundamental roles in the maintenance of brain homeostasis. The dysfunction of these cells is widely associated with brain disorders, which are often characterized by variations in the astrocyte protein markers GFAP and S100B, in addition ...
Jéssica Taday, Fernanda Telles Fróes, Marina Seady, Carlos Alberto Gonçalves, Marina Concli Leite   +4 more
doaj   +1 more source

Quantitative studies of hepatocytes in periportal and perivenous zones of the liver lobules in diabetic rats [PDF]

, 2007
This study was designed to evaluate the morphometric changes of parenchymal cells in the periportal (Z1) and perivenous (Z3) zones of the liver lobules that occur after Streptozotocin-induced diabetes in rats.
Ghafari, S., Golalipour, M.J.
core  

Sequential ultrasound‐driven dynamic control of macrophage polarization combined with hydrogel for mechano‐chemical synergistic tissue repair

Interdisciplinary Medicine, EarlyView.
This study presents an innovative therapeutic strategy that integrates sequential ultrasound therapy with an injectable oxidized dextran‐metformin (ODE‐Met) hydrogel to dynamically regulate macrophage polarization and promote angiogenesis for inflamed tissue repair.
Fulong Man, Kun Wang, Zichen Yang, Lulu An, Caoyi You, Rongjie Li, Yanni Cai, Yang Li, Li Chen, Yiqiong Liu, Yan Li, Haiqing Dong, Yongyong Li   +12 more
wiley   +1 more source

Effects of decompression on behavioral, electrophysiologic, and histomorphologic recovery in a chronic sciatic nerve compression model of streptozotocin-induced diabetic rats

Journal of Pain Research, 2017
Ping-Hui Wang,1 Cheng-Chang Yang,2 Wei-Ren Su,3 Po-Ting Wu,3 Shun-Chien Cheng,1 I-Ming Jou4 1Department of Orthopedics, Chi-Mei Medical Center, 2Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 3Department of ...
Wang PH, Yang CC, Su WR, Wu PT, Cheng SC, Jou IM   +5 more
doaj  

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Mesenchymal Stem Cell‐Mediated Vascular Regeneration in Diabetic Foot Ulcers via the Notch Signaling Pathway

Journal of Clinical Laboratory Analysis, EarlyView.
This graphical abstract illustrates the experimental design and key findings of the study on the role of mesenchymal stem cells (MSCs) and Notch signaling in diabetic foot ulcer (DFU) healing. The study involved five groups of BALB/c mice: Control, Model, MSCs Treatment, MSCs + Notch Inhibition, and MSCs + Notch Activation.
Feifei Li, Li Xu, Xin Hou, Dengfeng Zhu, Jingming Ou, Zuwei Yang, Yuhong Gu   +6 more
wiley   +1 more source

Sustainable Intervention: Grape Pomace Flour Ameliorates Fasting Glucose and Mitigates Streptozotocin-Induced Pancreatic Damage in a Type 2 Diabetes Animal Model

Pharmaceuticals
Background/Objectives: Type 2 Diabetes Mellitus (T2DM) is characterized by hyperglycemia, increased risk of cardiovascular diseases, and oxidative imbalances.
Raphaela Cassol Piccoli, William Sanabria Simões, Solange Vega Custódio, Kelen Cristiane Machado Goularte, Karina Pereira Luduvico, Julia Eisenhardt de Mello, Anita Avila de Souza, Ana Carolina Teixeira, Diego Araujo da Costa, Alethéa Gatto Barschak, Bruna Ferrary Deniz, Wellington de Almeida, Paula Pereira, Marisa Nicolai, Roselia Maria Spanevello, Francieli Moro Stefanello, Rejane Giacomelli Tavares, Maria Lídia Palma   +17 more
doaj   +1 more source

The mechanisms of alloxan- and streptozotocin-induced diabetes

Diabetologia, 2008
S. Lenzen
semanticscholar   +1 more source

Clinical Implications of Ki‐67 Index, Grade and Hormonal Changes in Pancreatic Neuroendocrine Tumors: Insights Into Tumor Heterogeneity Based on Primary and Secondary Lesions

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Pancreatic neuroendocrine tumors (PanNETs) show heterogeneity, including temporal shifts in proliferation and hormone production; however, their clinical implications remain uncertain. Methods This retrospective study included 114 patients with metastatic or recurrent PanNETs at Kyushu University Hospital.
Masatoshi Murakami, Nao Fujimori, Kazuhide Matsumoto, Keijiro Ueda, Kohei Nakata, Masafumi Nakamura, Takeo Yamamoto, Yoshinao Oda, Tetsuhide Ito, Yoshihiro Ogawa   +9 more
wiley   +1 more source

Epigenetic inflammatory memory and periodontal disease: Mechanisms and clinical significance for comorbidities

Journal of Periodontology, EarlyView.
Abstract Historically, immunological memory was considered an exclusive feature of adaptive immunity. However, innate immune cells have recently been shown to record and maintain epigenetically imprinted memory of earlier infectious or inflammatory challenges.
George Hajishengallis
wiley   +1 more source