Results 41 to 50 of about 181,208 (343)

Wdr13 and streptozotocin-induced diabetes [PDF]

Nutrition & Diabetes, 2018
AbstractType I diabetes, though contributes to only 5–10% of total diabetes cases, is a rising concern in today’s world. Our previous studies have shown that the absence of WDR13 in mouse results in pancreatic β-cell hyper-proliferation. Also, amelioration of the diabetic phenotype on introgression of Wdr13-null (Wdr13-/0) mutation in genetically ...
Arun Prakash Mishra, Komala Yedella, Jyothi Lakshmi, Archana Bharadwaj Siva   +3 more
openaire   +2 more sources

Chemical composition, antioxidant and alpha-Glucosidase-Inhibiting activities of the aqueous and hydroethanolic extracts of Vaccinium myrtillus Leaves [PDF]

, 2017
Vaccinium myrtillus (bilberry) leaf is traditionally used in southeastern Europe for the treatment of diabetes. In the present study, the ability of bilberry leaf extracts to inhibit carbohydrate-hydrolyzing enzymes and restore glutathione concentration ...
Bljajic, Kristina, Cacic, Ana, de Carvalho, Isabel Saraiva, Jablan, Jasna, Koncic, Marijana Zovko, Petlevski, Roberta, Sostaric, Nina, Vujic, Lovorka   +7 more
core   +1 more source

Islet isolation assessment in man and large animals [PDF]

, 1990
Recent progress in islet isolation from the pancreas of large mammals including man, accentuated the need for the development of precise and reproducible techniques to assess islet yield.
Alejandro, R, Bretzel, RG, Carlo, VD, Falqui, L, Federlin, K, Gray, DWR, Hering, BJ, James, RFL, Kaufman, DB, Kneteman, NM, Lacy, PE, Lake, SP, London, NJM, Mintz, DH, Morris, PJ, Pozza, G, Rajotte, RV, Ricordi, C, Scharp, DW, Socci, C, Starzl, TE, Sutherland, DER, Tzakis, A, Viviani, G, Warnock, GL, Zeng, Y   +25 more
core   +1 more source

An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin

Nature, 2018
Small molecules containing the N-nitroso group, such as the bacterial natural product streptozotocin, are prominent carcinogens1,2 and important cancer chemotherapeutics3,4.
Tai L. Ng, R. Rohac, A. Mitchell, A. Boal, E. Balskus   +4 more
semanticscholar   +1 more source

Enrichment of Bioactive Lipids in Urinary Extracellular Vesicles and Evidence of Apoptosis in Kidneys of Hypertensive Diabetic Cathepsin B Knockout Mice after Streptozotocin Treatment

Biomedicines
Cathepsin B (CtsB) is a ubiquitously expressed cysteine protease that plays important roles in health and disease. Urinary extracellular vesicles (uEVs) are released from cells associated with urinary organs.
Whitney C. Schramm, Niharika Bala, Tanmay Arekar, Zeeshan Malik, Kevin M. Chacko, Russell L. Lewis, Nancy D. Denslow, Yogesh Scindia, Abdel A. Alli   +8 more
doaj   +1 more source

Prevention of Protein Glycation by Natural Compounds [PDF]

, 2015
Non-enzymatic protein glycosylation (glycation) contributes to many diseases and aging of organisms. It can be expected that inhibition of glycation may prolong the lifespan.
Bartosz, Grzegorz, Sadowska-Bartosz, Izabela   +1 more
core   +2 more sources

UHPLC/QTOF-MS-based metabolomics reveal the effect of Melastoma dodecandrum extract in type 2 diabetic rats

Pharmaceutical Biology, 2019
Context: Melastoma dodecandrum Lour. (Melastomataceae) is a traditional Chinese medicine. This is the first study to report a protective effect of the ethanol extract from M. dodecandrum (MDE) in type 2 diabetic (T2DM) rats. Objective: To investigate the
Jingyu Weng, Jingkai Zhou, Liqing Liang, Li Li   +3 more
doaj   +1 more source

A Comprehensive Study of Chronic Diabetes Complications in Streptozotocin-Induced Diabetic Rat

Makara Journal of Health Research, 2016
Background: The purpose of this study was to provide a reference of chronic diabetes complications by investigating the prolonged hyperglycemia effects on hematological, biochemical and histopathological changes (liver, kidney, spleen, cardiac muscle ...
Sinan MA Al-Mahmood, Tariq A. Razak, Shahrin TC Abdullah, Nik N. Fatnoon NA, Abdul H. Mohamed, Imad M. Al-Ani   +5 more
doaj   +1 more source

A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo [PDF]

, 2019
The pancreatic islet is a complex micro-organ containing numerous cell types, including endocrine, immune, and endothelial cells. The communication of these systems is lost upon isolation of the islets, and therefore the pathogenesis of diabetes can only
Conteh, Abass M., Day, Richard N., Dunn, Kenneth W., Kamocka, Malgorzata M., Linnemann, Amelia K., Martinez, Michelle M., Mirmira, Raghavendra G., Orr, Kara S., Piñeros, Annie R., Reissaus, Christopher A., Tersey, Sarah A., Twigg, Ashley N.   +11 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source