Results 91 to 100 of about 1,705,896 (280)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Effect of Lamination Angle and Thickness on Analysis of Composite Plate Under Thermo Mechanical Loading

Journal of Mechanical Engineering, 2017
Analytical formulation and solution of stress analysis of composite plate subjected to thermo mechanical loading for various ply orientation and thickness of lamina are studied.
Choudhury Arnab, Mondal Samar Chandra, Sarkar Susenjit   +2 more
doaj   +1 more source

Periodic Mechanical Stress Stimulates GIT1-Dependent Mitogenic Signals in Rat Chondrocytes Through ERK1/2 Activity

Cellular Physiology and Biochemistry, 2018
Background/Aims: The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively, but the mechanisms whereby chondrocytes sense and respond to mechanical stimuli remain to be determined.
Kewei Ren, Jilei Tang, Xuefeng Jiang, Huiqing Sun, Luming Nong, Nan Shen, Yanqing Gu   +6 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

RAPID NONDESTRUCTIVE MECHANICAL STRESS CONTROL

Electrical engineering & Electromechanics, 2013
The paper considers problems of nondestructive mechanical stress control device design. An analytical expression for calculation of EMF induced in the measuring winding of a converter is obtained.
O.V. Nabokova, V.V. Kozlov, V.F. Bezotosniy   +2 more
doaj  

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Electro-mechanical properties of REBCO coated conductors from various industrial manufacturers at 77 K, self-field and 4.2 K, 19 T

, 2015
Rare-earth-barium-copper-oxide (REBCO) tapes are now available from several industrial manufacturers and are very promising conductors in high field applications.
Barth, Christian, Mondonico, Giorgio, Senatore, Carmine   +2 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Relationship between fatigue life in the creep-fatigue region and stress-strain response [PDF]

On the basis of mechanical tests and metallographic studies, strainrange partitioned lives were predicted by introducing stress-strain materials parameters into the Universal Slopes Equation.
Berkovits, A., Nadiv, S.
core   +1 more source

Compression Stress Effect on Dislocations Movement and Crack propagation in Cubic Crystal [PDF]

, 2011
Fracture material is seriously problem in daily life, and it has connection with mechanical properties itself. The mechanical properties is belief depend on dislocation movement and crack propagation in the crystal.
Aprilia, Ely, Suprijadi, Yusfi, Meiqorry
core   +2 more sources