Results 101 to 110 of about 1,705,896 (280)

An experimental investigation on PZT behavior under mechanical and cycling loading

Journal of the Mechanical Behavior of Materials, 2013
The drive to produce electrical energy by directly compressing piezoceramic material using mechanical stress stands behind the present test series. To be able to correctly choose the right material, PZT disks manufactured by three different manufacturers
Abramovich Haim, Tsikchotsky Eugeny, Klein Gregory   +2 more
doaj   +1 more source

Periodic Mechanical Stress Activates PKCδ-Dependent EGFR Mitogenic Signals in Rat Chondrocytes via PI3K-Akt and ERK1/2

Cellular Physiology and Biochemistry, 2016
Background/Aims: The present study aimed to analyze the mechanisms by which periodic mechanical stress is translated into biochemical signals, and to verify the important role of signaling molecules including phosphatidylinositol-3-kinase (PI3K)-Akt ...
Peng He, Nan Shen, Gongming Gao, Xuefeng Jiang, Huiqing Sun, Dong Zhou, Nanwei Xu, Luming Nong, Kewei Ren   +8 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Coexisting ordinary elasticity and superfluidity in a model of defect-free supersolid

, 2006
We present the mechanics of a model of supersolid in the frame of the Gross-Pitaevskii equation at $T=0K$ that do not require defects nor vacancies. A set of coupled nonlinear partial differential equations plus boundary conditions is derived.
A. Bensoussan, A. F. Andreev, A. F. Andreev, A. F. Andreev, Christophe Josserand, D. A. Kirzhnits, D. A. Kirzhnits, E. Sánchez-Palencia, G. Bonfait, L. D. Landau, L. M. Milne-Thomson, L. P. Pitaevskiǐ, N. N. Bogoliubov, Sergio Rica, Yves Pomeau   +14 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Time-independent Anisotropic Plastic Behavior by Mechanical Subelement Models [PDF]

, 1983
The paper describes a procedure for modelling the anisotropic elastic-plastic behavior of metals in plane stress state by the mechanical sub-layer model.
Pian, T. H. H.
core   +1 more source

Stress-induced Eukaryotic Translational Regulatory Mechanisms

ArXiv
The eukaryotic protein synthesis process entails intricate stages governed by diverse mechanisms to tightly regulate translation. Translational regulation during stress is pivotal for maintaining cellular homeostasis, ensuring the accurate expression of essential proteins crucial for survival.
Mir, Dilawar Ahmad, Ma, Zhengxin, Horrocks, Jordan, Rogers, Aric N   +3 more
openaire   +4 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Glucocorticoid Alleviates Mechanical Stress-Induced Airway Inflammation and Remodeling in COPD via Transient Receptor Potential Canonical 1 Channel

International Journal of COPD, 2023
Xiaojuan Wu,1 Baolin Jia,2 Xiaobin Luo,1 Jing Wang,3 Minchao Li3 1Department of Respiratory and Critical Care Medicine, Suining Central Hospital, Suining, Sichuan, 629000, People’ s Republic of China; 2Department of Oral and Maxillofacial Surgery ...
Wu X, Jia B, Luo X, Wang J, Li M
doaj